| 1. |
- Hau, Sofie Olsson, et al.
(författare)
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Chemotherapy, host response and molecular dynamics in periampullary cancer : The CHAMP study
- 2020
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic cancer is still often synonymous with a fatal outcome. The term periampullary cancer includes pancreatic cancer and applies to the group of tumours found in proximity to the ampulla of Vater. Molecular events and immune response in the host during chemotherapy remain largely unexplored in this group of tumours. Therefore, the "Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer (CHAMP)" study aims to monitor these processes to gain new insight into this perplexing disease. Methods: The CHAMP study is a prospective, single-arm observational study. All patients diagnosed with pancreatic or other periampullary adenocarcinoma undergoing adjuvant or palliative chemotherapy treatment in the Department of Oncology, Skåne University Hospital, are invited to participate. Clinical and pathological data will be compiled at study entry. A single tissue microarray (TMA) block is constructed for each patient with a resected tumour and blood samples are drawn before, during and after chemotherapy in order to sample peripheral blood mononuclear cells (PBMC), cytokines and circulating tumour DNA (ctDNA). Next generation sequencing will be performed on tumour tissue and ctDNA to detect changes in the clonal landscape over space and time. Discussion: Despite the recent emergence of some promising biomarkers for periampullary cancer, there has been a lack of success in clinical implementation. Cancer cells continuously adapt and become resistant to treatment during chemotherapy. To be able to keep pace with and hopefully overtake this rapid evolution we must, with the help of new diagnostic tools, be ready to adapt and alter treatment accordingly. It seems to us that the only way forward is to gain a better understanding of the dynamics of the disease during treatment. With insights gained from the CHAMP study we hope to find answers to key questions in this largely unexplored territory. Trial registration: This study has been registered 30th October 2018 at clinicaltrials.gov as NCT03724994.
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| 2. |
- Sellgren, Ulf, et al.
(författare)
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Architecting Complex Engineered Systems
- 2020
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Ingår i: Proceedings of the Design Society. - : Cambridge University Press (CUP). - 2633-7762. ; , s. 2415-2424
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Konferensbidrag (refereegranskat)abstract
- Novel products are commonly realized by integrating heterogeneous technologies. Product architecting focus on defining the scheme by which the product functions are allocated to physical components. A DSM-based clustering method that integrates technical complexity and strategic concerns has previously been proposed. It has been shown that interaction weights in the DSM may affect the clustering result. A complexity-based interaction strength model to be used in DSM clustering is proposed here. The case study gives promising results from both interaction performance and safety points of view.
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| 3. |
- Williamsson, David, 1990-, et al.
(författare)
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Architecting a Modular Battery Electric Truck
- 2020
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Ingår i: ASME 2020 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference.. - : ASME International.
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Konferensbidrag (refereegranskat)abstract
- Product architecting involves conceptual system design, module identification (clustering) and product layout design. In this paper, we propose a new extended version of the previously introduced Integrated Modularization Methodology (IMM) that integrates technical complexity and business strategic concerns into product architecture clustering. The extended IMM (eIMM) adds physical interference and implementation dependent behavior into architecture clustering. The proposed method is logically verified by an industrial case, where the architecture of a presently developed battery electric truck is used as a test bench for studying if and how the product architecture DSM and eIMM approaches may enable us to identify module candidates that are reasonable trade-offs between technical complexity, business strategies and physical interferences. The case study indicates that the eIMM is able to propose a modular product architecture with reasonable module candidates from a technical complexity point of view, and without conflicting business strategies or intra-modular physical interferences.
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| 4. |
- Williamsson, David, et al.
(författare)
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Choosing proper relation weights in product architecture clustering : a literature review
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This technical report was conducted at the department YMS - PDM & CAD (Product Data Management & Computer Aided Design) at Scania and at KTH Royal Institute of Technology in Stockholm, Sweden. The report serves as a part delivery of a PhD project, within the area of modularization and product description, performed by the author.Scania is one of the leading truck, bus and engine manufacturers in the world and is today a part of TRATON SE (owned by Volkswagen AG), which is one of the world’s largest vehicle manufacturing groups. Scania has a successful history in vehicle modularization and claims it is one of the most important reasons why they are a leading company today. However, the Scania product has over the last years been developed into a Cyber-Physical System (CPS), with embedded software in focus, demanding the modularization methodology to support this new dimension. There is also a growing market regarding offline and online services, which also generates new demands.Earlier published research within the presented PhD project identified that a structured methodology which supports the development of the product architecture was needed at Scania, mainly to manage the increasing technical complexity in the Cyber-Physical Systems. Hence, a new clustering based method for product modularization that integrates product complexity and company business strategies was proposed by the author. The new method was named Integrated Modularization Methodology (IMM) due to the integrated approach for identifying module candidates during the clustering stage.One of the main challenges when using any clustering based modularization approach is to determine proper relation weights (importance), including the reasons behind the weights, and how the weights affects the clustering results. Hence, the main purpose of this technical report was to systematically investigate possible aspects which may affect the product architecture and thereby the relation weights, i.e. the reasons to consider when choosing proper relation weights in the architecture clustering analysis.The results from the report indicate that the importance of the design requirements needs to be reflected in the chosen relation weights, given that the DSM-clustering result is sensitive to the relative relation weights.
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