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Sökning: WFRF:(Wong L) > (2000-2004)

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  • Adcox, K, et al. (författare)
  • PHENIX detector overview
  • 2003
  • Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 499:2-3, s. 469-479
  • Tidskriftsartikel (refereegranskat)abstract
    • The PHENIX detector is designed to perform a broad study of A-A, p-A, and p-p collisions to investigate nuclear matter under extreme conditions. A wide variety of probes, sensitive to all timescales, are used to study systematic variations with species and energy as well as to measure the spin structure of the nucleon. Designing for the needs of the heavy-ion and polarized-proton programs has produced a detector with unparalleled capabilities. PHENIX measures electron and muon pairs, photons, and hadrons with excellent energy and momentum resolution. The detector consists of a large number of subsystems that are discussed in other papers in this volume. The overall design parameters of the detector are presented. (C) 2002 Elsevier Science B.V. All rights reserved.
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  • Ding, Hao, et al. (författare)
  • A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.
  • 2004
  • Ingår i: Nat Genet. - 1061-4036. ; 36:10, s. 1111-6
  • Tidskriftsartikel (refereegranskat)abstract
    • PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.
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  • Hillier, Ladeana W, et al. (författare)
  • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
  • 2004
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
  • Tidskriftsartikel (refereegranskat)abstract
    • We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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  • Shen, Weiming, et al. (författare)
  • Reference Architecture for Internet Based Intelligent Shop Floors
  • 2000
  • Ingår i: Proceedings of SPIE Conference on Network Intelligence. - : SPIE - International Society for Optical Engineering. ; , s. 63-72
  • Konferensbidrag (refereegranskat)abstract
    • Global competitiveness is causing manufacturing companies to change the way they do business. New ways of viewing markets and competition have led the movement from legacy information systems to Internet-based environments. Success in manufacturing depends on being able to respond quickly, accurately and consistently to the changing needs of the marketplace. The need to control and optimize processes and to vary the necessary parameters to obtain the best product on time and on specification has fostered a change from centralized or hierarchical to distributed manufacturing control systems. This paper proposes a reference architecture for Internet-based intelligent shop floors. Internet, Web technologies, and intelligent agents are the key technologies adopted in this approach. The reference architecture provides the framework for components of a complex control system to work together as a whole rather than as a disjoint set. It encompasses both information architecture and integration methodologies. The primary aspects of the reference architecture under consideration include: (1) statement of scope and purpose; (2) domain analysis; (3) architectural specification; and (4) methodology for architectural development and system design.
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