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Tri-modal imaging o...
Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound : an in vitro study
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Kuhn, Joel (author)
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Papanastasiou, Giorgos (author)
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- Tai, Cheuk-Wai (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Moran, Carmel M. (author)
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Jansen, Maurits A. (author)
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Tavares, Adriana A. S. (author)
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Lennen, Ross J. (author)
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Corral, Carlos Alcaide (author)
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Wang, Chengjia (author)
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Thomson, Adrian J. W. (author)
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Berry, Catherine C. (author)
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Yiu, Humphrey H. P. (author)
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(creator_code:org_t)
- Future Medicine Ltd, 2020
- 2020
- English.
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In: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 15:25
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with theirin vitrocytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- computed tomography
- Fe3O4 magnetite nanoparticles
- Gold deposition
- MRI
- MR-CT-IVUS imaging
- multimodal imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kuhn, Joel
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Papanastasiou, G ...
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Tai, Cheuk-Wai
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Moran, Carmel M.
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Jansen, Maurits ...
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Tavares, Adriana ...
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show more...
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Lennen, Ross J.
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Corral, Carlos A ...
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Wang, Chengjia
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Thomson, Adrian ...
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Berry, Catherine ...
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Yiu, Humphrey H. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Nanomedicine
- By the university
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Stockholm University