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Incidence, diagnosi...
Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)
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- Reintam Blaser, A. (författare)
- Cantonal Hospital Lucerne,Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.;Lucerne Cantonal Hosp, Dept Intens Care Med, Luzern, Switzerland.
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- Acosta, S. (författare)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Lund Univ, Dept Clin Sci, Malmo, Sweden.
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J.-j., Mah (författare)
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- Björck, Martin (författare)
- Uppsala universitet,Kärlkirurgi,Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.
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- Bala, Miklosh (författare)
- Hebrew Univ Jerusalem, Hadassah Med Ctr, Jerusalem, Israel.;Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
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- Bodnar, Zsolt (författare)
- Letterkenny Univ Hosp, Letterkenny, Ireland.
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- Casian, Dumitru (författare)
- Nicolae Testemitanu State Univ Med & Pharm Republ, Univ Clin Vasc Surg, Kishinev, Moldova.
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- Demetrashvili, Zaza (författare)
- N Kipshidze Cent Univ Hosp, Tbilisi, Georgia.
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- D'Oria, Mario (författare)
- Univ Hosp Trieste ASUGI, Trieste, Italy.
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- Munoz-Cruzado, Virginia Duran (författare)
- Virgen del Rocio Univ Hosp, Seville, Spain.
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- Forbes, Alastair (författare)
- Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.
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- Fuglseth, Hanne (författare)
- Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway.
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- Itzhaki, Moran Hellerman (författare)
- Tel Aviv Univ, Intens Care Unit, Rabin Med Ctr, Petah Tiqwa, Israel.;Tel Aviv Univ, Inst Nutr Res, Rabin Med Ctr, Petah Tiqwa, Israel.
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- Hess, Benjamin (författare)
- Lucerne Cantonal Hosp, Dept Intens Care Med, Luzern, Switzerland.
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- Kase, Karri (författare)
- Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.;Tartu Univ Hosp, Puusepa 8, Tartu, Estonia.,Sarawak Gen Hosp, Colorectal Surg, Kuching, Malaysia.
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- Kirov, Mikhail (författare)
- Northern State Med Univ, Dept Anesthesiol & Intens Care Med, Arkhangelsk, Russia.;City Hosp 1, Arkhangelsk, Russia.
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- Lein, Kristoffer (författare)
- Univ Hosp North Norway, Tromso, Norway.;UiT Arctic Univ Norway, Tromso, Norway.
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- Lindner, Matthias (författare)
- Univ Klinikum Schleswig Holstein, Campus Kiel, Kiel, Germany.
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- Loudet, Cecilia Ines (författare)
- Hosp Gen San Martin La Plata, Buenos Aires, Argentina.
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- Mole, Damian J. (författare)
- Univ Edinburgh, Royal Infirm Edinburgh, Chair Surg, Ctr Inflammat Res, Edinburgh, Scotland.
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- Nuzzo, Alexandre (författare)
- Paris Cite Univ, Beaujon Hosp, AP HP Nord, Dept Gastroenterol IBD & Intestinal Failure,Intest, Paris, France.
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- Starkopf, Joel (författare)
- Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.;Tartu Univ Hosp, Puusepa 8, Tartu, Estonia.
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- Talving, Peep (författare)
- Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.;North Estonia Med Ctr, Div Acute Care Surg, Tallinn, Estonia.
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- Voomets, Anna-Liisa (författare)
- Tartu Univ Hosp, Puusepa 8, Tartu, Estonia.
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- Yunus, Mohammad Alif (författare)
- Hosp Melaka, Gen Surg Dept, Malacca, Malaysia.
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- Tamme, Kadri (författare)
- Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia.;Tartu Univ Hosp, Puusepa 8, Tartu, Estonia.
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Cantonal Hospital Lucerne Univ Tartu, Inst Clin Med, Puusepa 8, EE-50406 Tartu, Estonia;Lucerne Cantonal Hosp, Dept Intens Care Med, Luzern, Switzerland. (creator_code:org_t)
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- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: Critical Care. - : BioMed Central (BMC). - 1364-8535 .- 1466-609X. ; 28:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: The aim of this multicentre prospective observational study was to identify the incidence, patient characteristics, diagnostic pathway, management and outcome of acute mesenteric ischaemia (AMI). Methods: All adult patients with clinical suspicion of AMI admitted or transferred to 32 participating hospitals from 06.06.2022 to 05.04.2023 were included. Participants who were subsequently shown not to have AMI or had localized intestinal gangrene due to strangulating bowel obstruction had only baseline and outcome data collected. Results: AMI occurred in 0.038% of adult admissions in participating acute care hospitals worldwide. From a total of 705 included patients, 418 patients had confirmed AMI. In 69% AMI was the primary reason for admission, while in 31% AMI occurred after having been admitted with another diagnosis. Median time from onset of symptoms to hospital admission in patients admitted due to AMI was 24 h (interquartile range 9-48h) and time from admission to diagnosis was 6h (1–12 h). Occlusive arterial AMI was diagnosed in 231 (55.3%), venous in 73 (17.5%), non-occlusive (NOMI) in 55 (13.2%), other type in 11 (2.6%) and the subtype could not be classified in 48 (11.5%) patients. Surgery was the initial management in 242 (58%) patients, of which 59 (24.4%) underwent revascularization. Endovascular revascularization alone was carried out in 54 (13%), conservative treatment in 76 (18%) and palliative care in 46 (11%) patients. From patients with occlusive arterial AMI, revascularization was undertaken in 104 (45%), with 40 (38%) of them in one site admitting selected patients. Overall in-hospital and 90-day mortality of AMI was 49% and 53.3%, respectively, and among subtypes was lowest for venous AMI (13.7% and 16.4%) and highest for NOMI (72.7% and 74.5%). There was a high variability between participating sites for most variables studied. Conclusions: The overall incidence of AMI and AMI subtypes varies worldwide, and case ascertainment is challenging. Pre-hospital delay in presentation was greater than delays after arriving at hospital. Surgery without revascularization was the most common management approach. Nearly half of the patients with AMI died during their index hospitalization. Together, these findings suggest a need for greater awareness of AMI, and better guidance in diagnosis and management. Trial registration: NCT05218863 (registered 19.01.2022).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Diagnosis
- Epidemiology
- Management
- Mesenteric ischaemia
- Outcome
- anticoagulant agent
- antithrombocytic agent
- adult
- aged
- Article
- clinical trial
- cohort analysis
- conservative treatment
- emergency care
- endovascular surgery
- female
- gangrene
- hospital
- hospital admission
- human
- in-hospital mortality
- incidence
- intestine obstruction
- laparoscopic surgery
- laparotomy
- major clinical study
- male
- mesenteric ischemia
- multicenter study
- observational study
- onset age
- outcomes research
- palliative therapy
- patient care
- patient selection
- patient transport
- prospective study
- revascularization
- symptom
- terminal care
- Mesenteric ischaemia
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Reintam Blaser, ...
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Acosta, S.
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J.-j., Mah
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Björck, Martin
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Bala, Miklosh
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Bodnar, Zsolt
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visa fler...
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Casian, Dumitru
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Demetrashvili, Z ...
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D'Oria, Mario
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Munoz-Cruzado, V ...
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Forbes, Alastair
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Fuglseth, Hanne
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Itzhaki, Moran H ...
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Hess, Benjamin
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Kase, Karri
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Kirov, Mikhail
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Lein, Kristoffer
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Lindner, Matthia ...
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Loudet, Cecilia ...
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Mole, Damian J.
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Nuzzo, Alexandre
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Starkopf, Joel
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Talving, Peep
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Voomets, Anna-Li ...
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Yunus, Mohammad ...
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Tamme, Kadri
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Critical Care
- Av lärosätet
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Lunds universitet
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Uppsala universitet