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Genomic signature o...
Genomic signature of parity in the breast of premenopausal women
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Santucci-Pereira, Julia (författare)
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Zeleniuch-Jacquotte, Anne (författare)
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Afanasyeva, Yelena (författare)
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Zhong, Hua (författare)
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Slifker, Michael (författare)
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Peri, Suraj (författare)
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Ross, Eric A (författare)
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López de Cicco, Ricardo (författare)
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Zhai, Yubo (författare)
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Nguyen, Theresa (författare)
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Sheriff, Fathima (författare)
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Russo, Irma H (författare)
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Su, Yanrong (författare)
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Arslan, Alan A (författare)
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Bordas, Pal (författare)
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- Lenner, Per (författare)
- Umeå universitet,Onkologi
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Åhman, Janet (författare)
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Landström Eriksson, Anna Stina (författare)
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- Johansson, Robert (författare)
- Umeå universitet,Enheten för biobanksforskning
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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Toniolo, Paolo (författare)
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Russo, Jose (författare)
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(creator_code:org_t)
- 2019-03-28
- 2019
- Engelska.
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Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 21:1
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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visa fler...
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https://breast-cance...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Full-term pregnancy (FTP) at an early age confers long-term protection against breast cancer. Previously, we reported that a FTP imprints a specific gene expression profile in the breast of postmenopausal women. Herein, we evaluated gene expression changes induced by parity in the breast of premenopausal women.METHODS: Gene expression profiling of normal breast tissue from 30 nulliparous (NP) and 79 parous (P) premenopausal volunteers was performed using Affymetrix microarrays. In addition to a discovery/validation analysis, we conducted an analysis of gene expression differences in P vs. NP women as a function of time since last FTP. Finally, a laser capture microdissection substudy was performed to compare the gene expression profile in the whole breast biopsy with that in the epithelial and stromal tissues.RESULTS: Discovery/validation analysis identified 43 differentially expressed genes in P vs. NP breast. Analysis of expression as a function of time since FTP revealed 286 differentially expressed genes (238 up- and 48 downregulated) comparing all P vs. all NP, and/or P women whose last FTP was less than 5 years before biopsy vs. all NP women. The upregulated genes showed three expression patterns: (1) transient: genes upregulated after FTP but whose expression levels returned to NP levels. These genes were mainly related to immune response, specifically activation of T cells. (2) Long-term changing: genes upregulated following FTP, whose expression levels decreased with increasing time since FTP but did not return to NP levels. These were related to immune response and development. (3) Long-term constant: genes that remained upregulated in parous compared to nulliparous breast, independently of time since FTP. These were mainly involved in development/cell differentiation processes, and also chromatin remodeling. Lastly, we found that the gene expression in whole tissue was a weighted average of the expression in epithelial and stromal tissues.CONCLUSIONS: Genes transiently activated by FTP may have a role in protecting the mammary gland against neoplastically transformed cells through activation of T cells. Furthermore, chromatin remodeling and cell differentiation, represented by the genes that are maintained upregulated long after the FTP, may be responsible for the lasting preventive effect against breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer risk
- Breast differentiation
- Gene expression profiling
- Immune response
- Normal breast transcriptome
- Parous and nulliparous breast transcriptome
- Pregnancy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Santucci-Pereira ...
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Zeleniuch-Jacquo ...
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Afanasyeva, Yele ...
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Zhong, Hua
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Slifker, Michael
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Peri, Suraj
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visa fler...
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Ross, Eric A
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López de Cicco, ...
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Zhai, Yubo
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Nguyen, Theresa
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Sheriff, Fathima
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Russo, Irma H
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Su, Yanrong
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Arslan, Alan A
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Bordas, Pal
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Lenner, Per
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Åhman, Janet
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Landström Erikss ...
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Johansson, Rober ...
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Hallmans, Göran, ...
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Toniolo, Paolo
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Russo, Jose
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Breast Cancer Re ...
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