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Strategies and chal...
Strategies and challenges with the microbial conversion of methanol to high-value chemicals
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- Zhan, Chunjun, 1986 (författare)
- Jiangnan University,Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Xiaowei, 1986 (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology
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- Yang, Yankun (författare)
- Jiangnan University
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visa fler...
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- Nielsen, Jens B, 1962 (författare)
- BioInnovation Institute (BII),Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology
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- Bai, Zhonghu (författare)
- Jiangnan University
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- Chen, Yun, 1978 (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology
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visa färre...
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(creator_code:org_t)
- 2021-06-25
- 2021
- Engelska.
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Ingår i: Biotechnology and Bioengineering. - : Wiley. - 0006-3592 .- 1097-0290. ; 118:10, s. 3655-3668
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://onlinelibrar...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- As alternatives to traditional fermentation substrates, methanol (CH3OH), carbon dioxide (CO2) and methane (CH4) represent promising one-carbon (C1) sources that are readily available at low-cost and share similar metabolic pathway. Of these C1 compounds, methanol is used as a carbon and energy source by native methylotrophs, and can be obtained from CO2 and CH4 by chemical catalysis. Therefore, constructing and rewiring methanol utilization pathways may enable the use of one-carbon sources for microbial fermentations. Recent bioengineering efforts have shown that both native and nonnative methylotrophic organisms can be engineered to convert methanol, together with other carbon sources, into biofuels and other commodity chemicals. However, many challenges remain and must be overcome before industrial-scale bioprocessing can be established using these engineered cell refineries. Here, we provide a comprehensive summary and comparison of methanol metabolic pathways from different methylotrophs, followed by a review of recent progress in engineering methanol metabolic pathways in vitro and in vivo to produce chemicals. We discuss the major challenges associated with establishing efficient methanol metabolic pathways in microbial cells, and propose improved designs for future engineering.
Ämnesord
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap -- Förnyelsebar bioenergi (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences -- Renewable Bioenergy Research (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Annan naturresursteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Other Environmental Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Energisystem (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Energy Systems (hsv//eng)
Nyckelord
- methanol
- redox cofactor
- intermediate recycling
- energy supply
- methylotrophs
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- Av författaren/redakt...
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Zhan, Chunjun, 1 ...
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Li, Xiaowei, 198 ...
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Yang, Yankun
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Nielsen, Jens B, ...
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Bai, Zhonghu
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Chen, Yun, 1978
- Om ämnet
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Annan lantbruksv ...
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och Förnyelsebar bio ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Naturresurstekni ...
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och Annan naturresur ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Naturresurstekni ...
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och Energisystem
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Biotechnology an ...
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Chalmers tekniska högskola