| 1. |
|
|
| 2. |
-
- 2019
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Demerath, Ellen W., et al.
(författare)
-
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
- 2015
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:15, s. 4464-4479
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA obtained from 2097 African American adults in the Atherosclerosis Risk in Communities (ARIC) study. Mixed-effects regression models were used to test the association of methylation beta value with concurrent body mass index (BMI) and waist circumference (WC), and BMI change, adjusting for batch effects and potential confounders. Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort. Seventy-six BMI-related probes, 164 WC-related probes and 8 BMI change-related probes passed the threshold for significance in ARIC (P < 1 x 10(-7); Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe. Sixteen of these also replicated in adipose tissue, including 15 novel methylation findings near genes involved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others. Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches.
|
|
| 4. |
- Ge, Qi, et al.
(författare)
-
Structure-Based Low-Rank Model With Graph Nuclear Norm Regularization for Noise Removal
- 2017
-
Ingår i: IEEE Transactions on Image Processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1057-7149 .- 1941-0042. ; 26:7, s. 3098-3112
-
Tidskriftsartikel (refereegranskat)abstract
- Nonlocal image representation methods, including group-based sparse coding and block-matching 3-D filtering, have shown their great performance in application to low-level tasks. The nonlocal prior is extracted from each group consisting of patches with similar intensities. Grouping patches based on intensity similarity, however, gives rise to disturbance and inaccuracy in estimation of the true images. To address this problem, we propose a structure-based low-rank model with graph nuclear norm regularization. We exploit the local manifold structure inside a patch and group the patches by the distance metric of manifold structure. With the manifold structure information, a graph nuclear norm regularization is established and incorporated into a low-rank approximation model. We then prove that the graph-based regularization is equivalent to a weighted nuclear norm and the proposed model can be solved by a weighted singular-value thresholding algorithm. Extensive experiments on additive white Gaussian noise removal and mixed noise removal demonstrate that the proposed method achieves a better performance than several state-of-the-art algorithms.
|
|
| 5. |
- Hinnemo, Malkolm, et al.
(författare)
-
Scalable residue-free graphene for surface-enhanced Raman scattering
- 2016
-
Ingår i: Carbon. - : Elsevier BV. - 0008-6223 .- 1873-3891. ; 98, s. 567-571
-
Tidskriftsartikel (refereegranskat)abstract
- A room-temperature polymer-assisted transfer process is developed for large-area, single-layer graphene grown by means of chemical vapor deposition (CVD). This process leads to transferred graphene layers free of polymer contamination. The absence of polymer residues boosts the surface-enhanced Raman scattering (SERS) of the CVD graphene with gold nanoparticles (Au NPs) deposited atop by evaporation. The SERS enhancement of the CVD graphene reaches similar to 120 for the characteristic 2D peak of graphene, the highest enhancement factor achieved to date, when the Au NPs are at the threshold of percolation. Our simulation supported by experiment suggests that the polymer residues persistently present on the graphene transferred by the conventional polymer-assisted method are equivalent to an ultrathin film of less than 1 nm thickness. The presence of polymer residues drastically reduces SERS due to the separation of the Au NPs from the underlying graphene. The scalability of CVD graphene opens up for the possibility of graphene-based SERS sensors.
|
|
| 6. |
- Kristan, Matej, et al.
(författare)
-
The Sixth Visual Object Tracking VOT2018 Challenge Results
- 2019
-
Ingår i: Computer Vision – ECCV 2018 Workshops. - Cham : Springer Publishing Company. - 9783030110086 - 9783030110093 ; , s. 3-53
-
Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2018 is the sixth annual tracker benchmarking activity organized by the VOT initiative. Results of over eighty trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis and a “real-time” experiment simulating a situation where a tracker processes images as if provided by a continuously running sensor. A long-term tracking subchallenge has been introduced to the set of standard VOT sub-challenges. The new subchallenge focuses on long-term tracking properties, namely coping with target disappearance and reappearance. A new dataset has been compiled and a performance evaluation methodology that focuses on long-term tracking capabilities has been adopted. The VOT toolkit has been updated to support both standard short-term and the new long-term tracking subchallenges. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website (http://votchallenge.net).
|
|
| 7. |
- Li, Hui, et al.
(författare)
-
Accelerating Gas Adsorption on 3D Percolating Carbon Nanotubes
- 2016
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- In the field of electronic gas sensing, low-dimensional semiconductors such as single-walled carbon nanotubes (SWCNTs) can offer high detection sensitivity owing to their unprecedentedly large surface-to-volume ratio. The sensitivity and responsivity can further improve by increasing their areal density. Here, an accelerated gas adsorption is demonstrated by exploiting volumetric effects via dispersion of SWCNTs into a percolating three-dimensional (3D) network in a semiconducting polymer. The resultant semiconducting composite film is evaluated as a sensing membrane in field effect transistor (FET) sensors. In order to attain reproducible characteristics of the FET sensors, a pulsed-gate-bias measurement technique is adopted to eliminate current hysteresis and drift of sensing baseline. The rate of gas adsorption follows the Langmuir-type isotherm as a function of gas concentration and scales with film thickness. This rate is up to 5 times higher in the composite than only with an SWCNT network in the transistor channel, which in turn results in a 7-fold shorter time constant of adsorption with the composite. The description of gas adsorption developed in the present work is generic for all semiconductors and the demonstrated composite with 3D percolating SWCNTs dispersed in functional polymer represents a promising new type of material for advanced gas sensors.
|
|
| 8. |
- Li, Hui, et al.
(författare)
-
MIMO systems and antennas for terminals
- 2016
-
Ingår i: Handbook of Antenna Technologies. - Singapore : Springer Singapore. - 9789814560436 - 9789814560757 ; , s. 2347-2388
-
Bokkapitel (refereegranskat)abstract
- MIMO technology has facilitated tremendous performance improvements in wireless communications, allowing the data rate to increase linearly with the number of antennas used, at no additional expense in transmit power or spectrum. However, the tremendous performance gain can only be achieved by multi-antenna designs that provide low coupling and correlation, as well as high total efficiency. Such design criteria are especially challenging for small terminal devices. The situation becomes even more complicated with increasing bandwidth requirements for terminals in existing and upcoming mobile communication standards. Beginning with the history of MIMO terminal antenna and its evaluation methods, this chapter is geared towards providing useful guidelines to researchers and practitioners alike on how to design efficient MIMO antennas for terminals. The focus is on decoupling and decorrelation techniques, including RF circuit level decoupling, antenna structure decoupling and characteristic mode based decoupling. Future directions in MIMO antenna design and some corresponding open problems are also described.
|
|
| 9. |
- Li, Hui, et al.
(författare)
-
Trion-induced current anomaly in organic polymer
- 2016
-
Ingår i: Organic electronics. - : Elsevier BV. - 1566-1199 .- 1878-5530. ; 34, s. 124-129
-
Tidskriftsartikel (refereegranskat)abstract
- In this report, an anomalous time-evolution of electrical current in organic thin-film transistors, OTFTs, isrevealed by employing a specially tailored semiconductor composite channel. The composite is designedby controlling the density of carbon nanotubes dispersed in a host semiconducting polymer belowelectrical percolation. The current anomaly, which, to the best of our knowledge, has never beenobserved before, is directly correlated to strong many-body interactions instantaneously occurring in thesystem under investigation. In essence, two on-chain positively charged polarons are fused with anelectrochemically generated negative hydroxyl ion, OH, in the H2O/O2redox reaction to form a trion.The trion, which is characteristic of the polymer, is intrinsically metastable and can dissociate to mobilepolarons under the influence of electricfield, temperature and/or light illumination. The rate of trionformation is almost three orders of magnitude higher than that of trion dissociation. The fast formationand slow dissociation of the trions is the cause responsible for the observed current anomaly. Themetastable trion is, hence, of fundamental importance in the operation of OTFTs. Understanding thefundamentals pertaining to the anomalous phenomenon not only is crucial for design of more efficientdevices but also can guide development of future, emerging applications of OTFTs.
|
|
| 10. |
-
Narratives of Norrköping
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Narratives of Norrköping, the 3rd edition of the REMS publication, aims to be exactly as the title suggests: a collection of narratives from a spectrum of different people residing in our city of Norrköping.As with previous editions, this magazine has been created by 1st year students of the Ethnic and Migration Studies Master’s programme of Linköping University. An eclectic mix of people in their own right, the authors of the following texts have a hugely diverse and rich background of different cultures and narratives. They came together here in Norrköping to learn more about the ever more important field of migration and ethnicity.An interdisciplinary and transformative course like Ethnic and Migration Studies constantly shifts the world view of the students studying it. From the way we look at political systems, to how minorities and refugees are treated; analysing infinitely different aspects of society can only lead us to change how we associate with the city around us. Norrköping is the city that now the majority of us call home, and it was a pleasure to come together to look outwards into the community to create this work.The large variety of different authors brought together can be seen in the writing and design styles, which are individual to the authors. Both a mix of academic and journalistic styles, we hope that the reader can appreciate the personal touch of each of the pieces.Authors aside, we would also like to give special thanks to the support and teachings of the staff of REMESO, and we must be particularly grateful to the fellow local residents who have been interviewed and have been willing to tell their story to a group of over enthusiastic students. Without them, there would be no stories to tell, and equally no community around us.We hope that the following articles will provide some insight into the lives of more of the people around us, the city of Norrköping itself, and more of a taste of the forever enriching and changing culture surrounding us.Special thanks to the following people who went above and beyond to give their time, also to those who preferred to stay anonymous:Asher Goldstein, Caroline Bielkhammar, Casey Maier, Erik Stenström, Hammam Skaik, Helena Balthammar, Helene Hedebris, Lars Stjernkvist, Mia Sköld, Roberto Felizia, Sahar Burhan, Samantha McCorkell, Yaghia Narsisian, Zoran SlavnicEthnic and Migration Studies (EMS), class of 2018
|
|
| 11. |
- Shao, Wen-Ze, et al.
(författare)
-
Motion Deblurring Using Non-stationary Image Modeling
- 2015
-
Ingår i: Journal of Mathematical Imaging and Vision. - : Springer Science and Business Media LLC. - 0924-9907 .- 1573-7683. ; 52:2, s. 234-248
-
Tidskriftsartikel (refereegranskat)abstract
- It is well-known that shaken cameras or mobile phones during exposure usually lead to motion blurry photographs. Therefore, camera shake deblurring or motion deblurring is required and requested in many practical scenarios. The contribution of this paper is the proposal of a simple yet effective approach for motion blur kernel estimation, i.e., blind motion deblurring. Though there have been proposed severalmethods formotion blur kernel estimation in the literature, we impose a type of non-stationary Gaussian prior on the gradient fields of sharp images, in order to automatically detect and purse the salient edges of images as the important clues to blur kernel estimation. On one hand, the prior is able to promote sparsity inherited in the non-stationarity of the precision parameters (inverse of variances). On the other hand, since the prior is in a Gaussian form, there exists a great possibility of deducing a conceptually simple and computationally tractable inference scheme. Specifically, the well-known expectation-maximization algorithm is used to alternatingly estimate the motion blur kernels, the salient edges of images as well as the precision parameters in the image prior. In difference from many existing methods, no hyperpriors are imposed on any parameters in this paper; there are not any pre-processing steps involved in the proposed method, either, such as explicit suppression of random noise or prediction of salient edge structures. With estimated motion blur kernels, the deblurred images are finally generated using an off-the-shelf non-blind deconvolution method proposed by Krishnan and Fergus (Adv Neural Inf Process Syst 22:1033-1041, 2009). The rationality and effectiveness of our proposed method have been well demonstrated by the experimental results on both synthetic and realistic motion blurry images, showing state-of-the-art blind motion deblurring performance of the proposed approach in the term of quantitative metric as well as visual perception.
|
|
| 12. |
- Sun, Hui-Min, et al.
(författare)
-
SERPINA4 is a novel independent prognostic indicator and a potential therapeutic target for colorectal cancer
- 2016
-
Ingår i: American Journal of Cancer Research. - Madison : E-CENTURY PUBLISHING CORP. - 2156-6976. ; 6:8, s. 1636-1649
-
Tidskriftsartikel (refereegranskat)abstract
- Serpina family A member 4 (SERPINA4), also known as kallistatin, exerts important effects in inhibiting tumor growth and angiogenesis in many malignancies. However, the precise role of SERPINA4 in CRC has not been fully elucidated. The present study aimed to investigate the expression of SERPINA4 and its clinical significance in CRC. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analyses showed that the mRNA and protein expression of SERPINA4 in colorectal cancer (CRC) specimens was significantly decreased than that in adjacent normal mucosa. Immunohistochemistry (IHC) was conducted to characterize the expression pattern of SERPINA4 by using a tissue microarray (TMA) containing 327 archived paraffin-embedded CRC specimens. Statistical analyses revealed that decreased SERPINA4 expression was significantly associated with invasion depth, nodal involvement, distant metastasis, American Joint Committee on Cancer (AJCC) stage, and tumor differentiation. SERPINA4 was also an independent prognostic indicator of disease-free survival and overall survival in patients with CRC. Furthermore, the impact of altered SERPINA4 expression on CRC cells was analyzed with a series of in vitro and in vivo assays. The results demonstrated that SERPINA4 significantly inhibits malignant tumor progression and serves as a novel prognostic indicator and a potential therapeutic target for CRC.
|
|
| 13. |
- Tao, Bairui, et al.
(författare)
-
Three-dimensional graphene nanosheets supported by NiO/Si-MCP as electrode materials for high-performance supercapacitors
- 2017
-
Ingår i: Ionics (Kiel). - : Springer Science and Business Media LLC. - 0947-7047 .- 1862-0760. ; 23:8, s. 2185-2191
-
Tidskriftsartikel (refereegranskat)abstract
- A three-dimensional (3D) graphene/NiO/Si-microchannel (MCP) composite electrode is synthesized by the conventional microelectronic machining process and electrochemical exfoliation technology for electrochemical capacitors. SEM, AFM, and Raman scattering are used to investigate the morphology and structure, and electrochemical characterization reveals that the 3D graphene/NiO/Si-MCP has a high specific capacitance of 833 Fg-1 at a current density of 5 Ag-1 in 6 mol L-1 KOH. Moreover, good cycling performance with 92% capacitance retention after 1000 cycles is observed indicating the novel electrode has large potential in high-performance supercapacitors.
|
|
| 14. |
- Wang, Peng, et al.
(författare)
-
Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray
- 2016
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 113:32, s. E4726-E4735
-
Tidskriftsartikel (refereegranskat)abstract
- The neuropeptide galanin coexists in rat brain with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus (LC), and it has been suggested to be involved in depression. We studied rats exposed to chronic mild stress (CMS), a rodent model of depression. As expected, these rats showed several endophenotypes relevant to depression-like behavior compared with controls. All these endophenotypes were normalized after administration of a selective serotonin reuptake inhibitor. The transcripts for galanin and two of its receptors, galanin receptor 1 (GALR1) and GALR2, were analyzed with quantitative real-time PCR using laser capture microdissection in the following brain regions: the hippocampal formation, LC, and ventral periaqueductal gray (vPAG). Only Galr1 mRNA levels were significantly increased, and only in the latter region. After knocking down Galr1 in the vPAG with an siRNA technique, all parameters of the depressive behavioral phenotype were similar to controls. Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.
|
|
| 15. |
- Wuttke, Matthias, et al.
(författare)
-
A catalog of genetic loci associated with kidney function from analyses of a million individuals
- 2019
-
Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 51:6, s. 957-972
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
|
|
| 16. |
- Zhang, Youwei, et al.
(författare)
-
On Valence-Band Splitting in Layered MoS2
- 2015
-
Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 9:8, s. 8514-8519
-
Tidskriftsartikel (refereegranskat)abstract
- As a representative two-dimensional semiconducting transition-metal dichalcogenide (TMD), the electronic structure in layered MoS2 is a collective result of quantum confinement, interlayer interaction, and crystal symmetry. A prominent energy splitting in the valence band gives rise to many intriguing electronic, optical, and magnetic phenomena. Despite numerous studies, an experimental determination of valence-band splitting in few-layer MoS2 is still lacking. Here, we show how the valence-band maximum (VBM) splits for one to five layers of MoS2. Interlayer coupling is found to contribute significantly to phonon energy but weakly to VBM splitting in bilayers, due to a small interlayer hopping energy for holes. Hence, spin-orbit coupling is still predominant in the splitting. A temperature-independent VBM splitting, known for single-layer MoS2, is, thus, observed for bilayers. However, a Bose-Einstein type of temperature dependence of VBM splitting prevails in three to five layers of MoS2. In such few-layer MoS2, interlayer coupling is enhanced with a reduced interlayer distance, but thermal expansion upon temperature increase tends to decouple adjacent layers and therefore decreases the splitting energy. Our findings that shed light on the distinctive behaviors about VBM splitting in layered MoS2 may apply to other hexagonal TMDs as well. They will also be helpful in extending our understanding of the TMD electronic structure for potential applications in electronics and optoelectronics.
|
|
| 17. |
- Zhang, Youwei, et al.
(författare)
-
Photothermoelectric and photovoltaic effects both present in MoS2
- 2015
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 5, s. 7938-
-
Tidskriftsartikel (refereegranskat)abstract
- As a finite-energy-bandgap alternative to graphene, semiconducting molybdenum disulfide (MoS2) has recently attracted extensive interest for energy and sensor applications. In particular for broad-spectral photodetectors, multilayer MoS2 is more appealing than its monolayer counterpart. However, little is understood regarding the physics underlying the photoresponse of multilayer MoS2. Here, we employ scanning photocurrent microscopy to identify the nature of photocurrent generated in multilayer MoS2 transistors. The generation and transport of photocurrent in multilayer MoS2 are found to differ from those in other low-dimensional materials that only contribute with either photovoltaic effect (PVE) or photothermoelectric effect (PTE). In multilayer MoS2, the PVE at the MoS2-metal interface dominates in the accumulation regime whereas the hot-carrier-assisted PTE prevails in the depletion regime. Besides, the anomalously large Seebeck coefficient observed in multilayer MoS2, which has also been reported by others, is caused by hot photo-excited carriers that are not in thermal equilibrium with the MoS2 lattice.
|
|
| 18. |
- Zhang, Youwei, et al.
(författare)
-
Thickness Considerations of Two-Dimensional Layered Semiconductors for Transistor Applications
- 2016
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Layered two-dimensional semiconductors have attracted tremendous attention owing to their demonstrated excellent transistor switching characteristics with a large ratio of on-state to off-state current, I-on/I-off. However, the depletion-mode nature of the transistors sets a limit on the thickness of the layered semiconductor films primarily determined by a given I-on/I-off as an acceptable specification. Identifying the optimum thickness range is of significance for material synthesis and device fabrication. Here, we systematically investigate the thickness-dependent switching behavior of transistors with a wide thickness range of multilayer-MoS2 films. A difference in I-on/I-off by several orders of magnitude is observed when the film thickness, t, approaches a critical depletion width. The decrease in I-on/I-off is exponential for t between 20 nm and 100 nm, by a factor of 10 for each additional 10 nm. For t larger than 100 nm, I-on/I-off approaches unity. Simulation using technical computer-aided tools established for silicon technology faithfully reproduces the experimentally determined scaling behavior of I-on/I-off with t. This excellent agreement confirms that multilayer-MoS2 films can be approximated as a homogeneous semiconductor with high surface conductivity that tends to deteriorate I-on/I-off. Our findings are helpful in guiding material synthesis and designing advanced field-effect transistors based on the layered semiconductors.
|
|
