| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
- He, YQ, et al.
(författare)
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A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966-
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Tidskriftsartikel (refereegranskat)abstract
- Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
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| 3. |
- Hong, Jie, et al.
(författare)
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Asymmetrically coupled co single-atom and co nanoparticle in double-shelled carbon-based nanoreactor for enhanced reversible oxygen catalysis
- 2023
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Ingår i: Chemical Engineering Journal. - : Elsevier. - 1385-8947 .- 1873-3212. ; 455
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Tidskriftsartikel (refereegranskat)abstract
- Simultaneous construction of size-asymmetric metal single atoms and nanoparticle active sites in advanced and robust carrier materials is particularly important yet challenging for efficient reversible oxygen catalysis. Herein, a facile “chemical etching/in-Situ capture” synthesis strategy was developed to fabricate a unique double-shelled carbon-based nanobox integrated with size-asymmetric Co single-atom (CoSA) and metallic Co nanoparticle (CoNP) moiety. As expected, this well-managed catalyst product yielded remarkable bifunctional electrocatalytic performances in alkaline electrolytes, with a decent half-wave potential of 0.886 V for oxygen reduction reaction (ORR) and a small overpotential of 341 mV at 10 mA/cm2 for oxygen evolution reaction (OER). Besides, this nanobox catalyst served as a cost-effective and efficient oxygen electrode in the assembled rechargeable ZABs, exceeding the mixed electrocatalyst of expensive Pt/C-RuO2, in terms of the elevated peak power density of 239 mW/cm2, the promoted specific capacity of 770 mAh/gZn, as well as the appreciable charge–discharge cycle stability. Theoretical calculations revealed that the strong interaction between the delicate CoSA site and CoNP phase, could effectively optimize the adsorption and desorption energy barriers of reaction intermediates on the designed catalyst surface, thus achieving synergistic enhancement of electrocatalytic activity towards ORR and OER. This finding affords a feasible and effective strategy to achieve highly active and durable bifunctional catalysts for both fundamental research and practical rechargeable ZABs applications.
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| 4. |
- Wang, Jinling, et al.
(författare)
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Urbanization in developing countries overrides catchment productivity in fueling inland water CO2 emissions
- 2022
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Ingår i: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 29:1, s. 1-4
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Tidskriftsartikel (refereegranskat)abstract
- We compiled a nationwide dataset of carbon dioxide (CO2) efflux from 1405 measurements, and found that lakes, reservoirs, and rivers emit a total of 61.9 ± 55.3 TgC as CO2 each year, corresponding to 6.3% of the annual total national CO2 emission in 2020. Our analysis showed that the presence of anthropogenic disturbances in catchments strongly influences the emission of CO2 from these waters in the non-pristine areas, masking the catchment productivity effect on the emission of CO2. Our results highlight the need for adjusting climate change models for taking into account anthropogenic effects on CO2 emissions from inland waters.
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| 5. |
- Xie, Xu-Qin, et al.
(författare)
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miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer
- 2020
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Ingår i: MOLECULAR THERAPY-ONCOLYTICS. - : CELL PRESS. - 2372-7705. ; 17, s. 320-331
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Tidskriftsartikel (refereegranskat)abstract
- Our previous study demonstrated that miR-124 was downregulated in colorectal cancer (CRC) compared with normal mucosa, and the downregulated expression of miR-124 was an independent prognostic factor in CRC patients. However, the function of miR-124 in CRC patients treated with chemotherapy is currently unclear. The aim of this study was to determine the miR-124 expression and its regulative role in oxaliplatin (L-OHP)-based chemotherapy of CRC patients. We observed that low miR-124 expression was correlated with worse overall survival (OS) in the 220 patients who received postoperative chemotherapy of 5-fluorouracil [5-FU] +leucovorin+L-OHP (FOLFOX) or capecitabine+L-OHP (XELOX). miR-124 overexpression promoted L-OHP-induced, but not 5-FU-induced, cytotoxicity and apoptosis in HT29 and SW480 cells. CAPN2 was a direct target of miR124, and its protein expression was reduced by forced expression of miR-124. miR-124 inhibited tumorigenesis and promoted OS of mice bearing xenograft tumors, especially upon L-OHP treatment. miR-124 also promoted L-OHP-induced apoptosis and restrained CAPN2 protein expression in xenograft tumors. Our results suggest that miR-124 could be considered as both a predictor of L-OHP-based chemotherapy for personalized treatment and a therapeutic target for CRC.
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| 6. |
- Zhou, Kai-Xia, et al.
(författare)
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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC
- 2021
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Ingår i: Journal of Immunology Research. - : Hindawi Limited. - 2314-7156 .- 2314-8861. ; 2021, s. 6694392-6694392
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Tidskriftsartikel (refereegranskat)abstract
- Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is known for its high resistance and low response to treatment. Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. However, the specific role of KPNA2 in PDAC remains unclear. In this study, we found that expression of KPNA2 was significantly upregulated in PDAC compared to adjacent nontumor tissue and its high expression was correlated with poor survival outcome by analyzing the GEO datasets. Similar KPNA2 expression pattern was also found in both human patient samples and KPC mouse models through IHC staining. Although KPNA2 knockdown failed to impair the vitality and migration ability of PDAC cells in vitro, the in vivo tumor growth was significantly impeded and the expression of immune checkpoint ligand PD-L1 was reduced by silencing KPNA2. Furthermore, we uncovered that KPNA2 modulated the expression of PD-L1 by mediating nuclear translocation of STAT3. Collectively, our data suggested that KPNA2 has the potential to serve as a promising biomarker for diagnosis in PDAC.
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| 7. |
- Zhou, Lihua, et al.
(författare)
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Post-traumatic growth and its influencing factors among Chinese women diagnosed with gynecological cancer: A cross-sectional study.
- 2021
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Ingår i: European Journal of Oncology Nursing. - : Elsevier BV. - 1462-3889 .- 1532-2122. ; 51
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The experience of cancer could lead to positive psychological changes following the struggle with diagnosis and treatment. Understanding post-traumatic growth and its influencing factors in women affected by gynecological cancer is essential to enhance their possibility of achieving positive changes. The purpose of this study was to describe the post-traumatic growth level and explore the influencing factors of post-traumatic growth in Chinese women diagnosed with gynecological cancer. Method: A cross-sectional survey with a convenience sampling method was employed to collect data using the Post-traumatic Growth Inventory (PTGI), Distress Disclosure Index (DDI), Medical Coping Modes Questionnaire (MCMQ), and Multidimensional Scale of Perceived Social Support (MSPSS). The questionnaires were administered to 344 participants recruited from two hospitals in Hefei City, the capital of Anhui Province in China, between March 2018 and March 2019. All statistical analyses were performed using nonparametric tests. The Mann-Whitney U Test was used to distinguish the intergroup differences. Correlations were evaluated with Spearman rank correlation coefficients. Results: Total score for PTGI was 56.5 (range 48.0-68.0). The subscale with the highest centesimal score in the PTGI was appreciation of life and the lowest was spiritual change. The top five items with the highest scores of PTGI belonged to appreciating life, personal strength, and relating to others. Self-disclosure, confrontation, avoidance, acceptance-resignation, perceived social support, education level, cancer type and the place they lived had significant influence on post-traumatic growth. Conclusions: The findings indicate that women who have high levels of perceived social support, confrontation, avoidance, self-disclosure and education level tend to experience more post-traumatic growth, while, conversely, high levels of acceptance-resignation have a negative influence on promoting post-traumatic growth. These meaningful findings propose new perspectives for promoting post-traumatic growth in Chinese women diagnosed with gynecological cancer.
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| 8. |
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| 9. |
- Zhou, Xin, et al.
(författare)
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3-(2,2,2-Trifluoroethoxy)propionitrile-based electrolytes for high energy density lithium metal batteries
- 2022
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Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 14:46, s. 17237-17246
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Tidskriftsartikel (refereegranskat)abstract
- In this study, 3-(2,2,2-trifluoroethoxy)-propionitrile (FEON), a fluorinated nitrile compound with high oxidative stability, low volatility and non-flammability, is introduced as an electrolyte solvent for high-energy density Li|NCM batteries. After optimization of the electrolyte as (0.8 M LiTFSI + 0.2 M LiODFB)/FEC : FEON (1 : 3, by vol., abbreviated as FF13), the FEON-based electrolyte exhibits better cycling performance for both the lithium metal anode and 4.4 V high-voltage NCM cathode, compared with those of a commercial carbonate electrolyte of 1 M LiPF6/EC : EMC : DMC (1 : 1 : 1, by vol.). As for the FF13 electrolyte, the maximum coordination number of 3 for FEON molecules in the solvation structure is disclosed through molecular dynamics simulation combined with Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy measurements. Furthermore, the solid electrolyte interphase on the lithium metal anode is enriched with organic components and LiF, which is proposed from FEON decomposition based on density functional theory calculations and X-ray photoelectron spectroscopy analysis. All the above results demonstrate that fluorinated nitrile electrolytes constitute a promising platform for high energy density Li|NCM batteries.
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| 10. |
- Zhou, Yongqiang, et al.
(författare)
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Unraveling the Role of Anthropogenic and Natural Drivers in Shaping the Molecular Composition and Biolability of Dissolved Organic Matter in Non-pristine Lakes
- 2022
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 56:7, s. 4655-4664
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Tidskriftsartikel (refereegranskat)abstract
- Lakes receive and actively process terrestrial dissolved organic matter (DOM) and play an important role in the global carbon cycle. Urbanization results in elevated inputs of nonpoint-source DOM to headwater streams. Retention of water in lakes allows time for alteration and transformation of the chemical composition of DOM by microbes and UV radiation. Yet, it remains unclear how anthropogenic and natural drivers impact the composition and biolability of DOM in non-pristine lakes. We used optical spectroscopy, Fourier transform ion cyclotron mass spectrometry, stable isotopic measurements, and laboratory bioincubations to investigate the chemical composition and biolability of DOM across two large data sets of lakes associated with a large gradient of urbanization in lowland Eastern China, encompassing a total of 99 lakes. We found that increased urban land use, gross domestic products, and population density in the catchment were associated with an elevated trophic level index, higher chlorophyll-a, higher bacterial abundance, and a higher amount of organic carbon with proportionally higher contribution of aliphatic and peptide-like DOM fractions, which can be highly biolabile. Catchment areas, water depth, lake area: catchment area, gross primary productivity, delta O-18-H2O, and bacterial abundance, however, had comparatively little linkage with DOM composition and biolability. Urban land use is currently intensifying in many developing countries, and our results anticipate an increase in the level of biolabile aliphatic DOM from nonpoint sources and accelerated carbon cycling in lake ecosystems in such regions.
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| 11. |
- Zhu, Zhenshuo, et al.
(författare)
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Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network
- 2021
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Ingår i: The FASEB Journal. - : John Wiley & Sons. - 0892-6638 .- 1530-6860. ; 35:6
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Tidskriftsartikel (refereegranskat)abstract
- The pluripotency gene regulatory network of porcine induced pluripotent stem cells(piPSCs), especially in epigenetics, remains elusive. To determine the biological function of epigenetics, we cultured piPSCs in different culture conditions. We found that activation of pluripotent gene- and pluripotency-related pathways requires the erasure of H3K9 methylation modification which was further influenced by mouse embryonic fibroblast (MEF) served feeder. By dissecting the dynamic change of H3K9 methylation during loss of pluripotency, we demonstrated that the H3K9 demethylases KDM3A and KDM3B regulated global H3K9me2/me3 level and that their co-depletion led to the collapse of the pluripotency gene regulatory network. Immunoprecipitation-mass spectrometry (IP-MS) provided evidence that KDM3A and KDM3B formed a complex to perform H3K9 demethylation. The genome-wide regulation analysis revealed that OCT4 (O) and SOX2 (S), the core pluripotency transcriptional activators, maintained the pluripotent state of piPSCs depending on the H3K9 hypomethylation. Further investigation revealed that O/S cooperating with histone demethylase complex containing KDM3A and KDM3B promoted pluripotency genes expression to maintain the pluripotent state of piPSCs. Together, these data offer a unique insight into the epigenetic pluripotency network of piPSCs.
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| 12. |
- Awasthi, S. K., et al.
(författare)
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Sequential presence of heavy metal resistant fungal communities influenced by biochar amendment in the poultry manure composting process
- 2021
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Ingår i: Journal of Cleaner Production. - : Elsevier. - 0959-6526 .- 1879-1786. ; 291
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we investigated the influence of coconut shell biochar (CSB) on heavy metal resistance fungi (HMRF) during poultry manure (PM) composting by 18 S rDNA Internal Transcribed Spacer Amplicon Sequencing analysis. Five different concentrations of CSB (2.5%, 5%, 7.5%, and 10% dry weights basis) were applied with a mixture of PM and wheat straw (5:1 ratio dry weight basis) and without CSB (CK) was used as control. The results showed that sequence number rose along with increasing CSB concentration but total relative abundance (RA) of HMRF decreased 56.33%, 74.65% in T4 and T5, respectively. However, greater RA of HMRF was found in T1 or without biochar applied treatment. The phylum of Basidiomycota was the dominant fungal community accounting for 61.14%, 6.16%, 32.18%, 74.65%, and 73.73% from T1 to T5 of the total fungi abundance, with wide presence of the Wallemiomycetes and Eurotiomycetes classes. The Wallemia and Aspergillus were the richest genus and species. Wallemia_sebi, Altemaria_alternata and Aspergillus_amoenus were detected having greater abundance among all treatments. Besides this, the network correlation pattern confirmed that the relative greater percentage of correlation among dominant HMRF community with bio-available HM and other physicochemical factors increased with the addition of biochar. There was reasonable infer that the biochar amendment in composting could constitute favorable habitat for an active fungal population.
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| 13. |
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| 14. |
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| 15. |
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| 16. |
- Dean, Kelsey R., et al.
(författare)
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Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder
- 2020
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 25:12, s. 3337-3349
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Tidskriftsartikel (refereegranskat)abstract
- Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery cohort of 83 warzone-related PTSD cases and 82 warzone-exposed controls, we identified a set of 343 candidate biomarkers. These candidate biomarkers were selected from an integrated approach using (1) data-driven methods, including Support Vector Machine with Recursive Feature Elimination and other standard or published methodologies, and (2) hypothesis-driven approaches, using previous genetic studies for polygenic risk, or other PTSD-related literature. After reassessment of ~30% of these participants, we refined this set of markers from 343 to 28, based on their performance and ability to track changes in phenotype over time. The final diagnostic panel of 28 features was validated in an independent cohort (26 cases, 26 controls) with good performance (AUC = 0.80, 81% accuracy, 85% sensitivity, and 77% specificity). The identification and validation of this diverse diagnostic panel represents a powerful and novel approach to improve accuracy and reduce bias in diagnosing combat-related PTSD.
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| 17. |
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| 18. |
- Gu, Peng, et al.
(författare)
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A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis
- 2023
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Ingår i: Cellular & Molecular Immunology. - London : Nature Publishing Group. - 1672-7681 .- 2042-0226. ; 20:10, s. 1156-1170
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Tidskriftsartikel (refereegranskat)abstract
- The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis, and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture (CLP)-challenged mice and Escherichia coli-challenged pigs. Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate (PPA) enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis. Mechanistically, PPA directly binds to sirtuin 2 (SIRT2) and increases reactive oxygen species (ROS) production for eventual bacterial clearance. Importantly, PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients. Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. © 2023, The Author(s), under exclusive licence to CSI and USTC.
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| 19. |
- Hu, Li-Peng, et al.
(författare)
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Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression
- 2022
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Ingår i: Molecular Therapy. - : Elsevier BV. - 1525-0024 .- 1525-0016. ; 30:10, s. 3284-3299
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Tidskriftsartikel (refereegranskat)abstract
- Existing evidence indicates that gut fungal dysbiosis might play a key role in the pathogenesis of colorectal cancer (CRC). We sought to explore whether reversing the fungal dysbiosis by terbinafine, an approved antifungal drug, might inhibit the development of CRC. A population-based study from Sweden identified a total of 185 patients who received terbinafine after their CRC diagnosis and found that they had a decreased risk of death (hazard ratio=0.50) and metastasis (hazard ratio=0.44) compared with patients without terbinafine administration. In multiple mouse models of CRC, administration of terbinafine decreased the fungal load, the fungus-induced myeloid-derived suppressor cell (MDSC) expansion, and the tumor burden. Fecal microbiota transplantation from mice without terbinafine treatment reversed MDSC infiltration and partially restored tumor proliferation. Mechanistically, terbinafine directly impaired tumor cell proliferation by reducing the ratio of nicotinamide adenine dinucleotide phosphate (NADP+) to reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), suppressing the activity of glucose-6-phosphate dehydrogenase (G6PD), resulting in nucleotide synthesis disruption, deoxyribonucleotide (dNTP) starvation and cell cycle arrest. Collectively, terbinafine can inhibit CRC by reversing fungal dysbiosis, suppressing tumor cell proliferation, inhibiting fungus-induced MDSC infiltration, and restoring antitumor immune response.
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| 20. |
- Jenniskens, Peter, et al.
(författare)
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The impact and recovery of asteroid 2018 LA
- 2021
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Ingår i: Meteoritics and Planetary Science. - : John Wiley & Sons. - 1086-9379 .- 1945-5100. ; 56:4, s. 844-893
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Tidskriftsartikel (refereegranskat)abstract
- The June 2, 2018 impact of asteroid 2018 LA over Botswana is only the second asteroid detected in space prior to impacting over land. Here, we report on the successful recovery of meteorites. Additional astrometric data refine the approach orbit and define the spin period and shape of the asteroid. Video observations of the fireball constrain the asteroid's position in its orbit and were used to triangulate the location of the fireball's main flare over the Central Kalahari Game Reserve. Twenty‐three meteorites were recovered. A consortium study of eight of these classifies Motopi Pan as an HED polymict breccia derived from howardite, cumulate and basaltic eucrite, and diogenite lithologies. Before impact, 2018 LA was a solid rock of ~156 cm diameter with high bulk density ~2.85 g cm−3, a relatively low albedo pV ~ 0.25, no significant opposition effect on the asteroid brightness, and an impact kinetic energy of ~0.2 kt. The orbit of 2018 LA is consistent with an origin at Vesta (or its Vestoids) and delivery into an Earth‐impacting orbit via the ν6 resonance. The impact that ejected 2018 LA in an orbit toward Earth occurred 22.8 ± 3.8 Ma ago. Zircons record a concordant U‐Pb age of 4563 ± 11 Ma and a consistent 207Pb/206Pb age of 4563 ± 6 Ma. A much younger Pb‐Pb phosphate resetting age of 4234 ± 41 Ma was found. From this impact chronology, we discuss what is the possible source crater of Motopi Pan and the age of Vesta's Veneneia impact basin.
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| 21. |
- Jin, Yingzhi, et al.
(författare)
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Solution-processed solar-charging power units made of organic photovoltaic modules and asymmetric super-capacitors
- 2021
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Ingår i: Applied Physics Letters. - : AMER INST PHYSICS. - 0003-6951 .- 1077-3118. ; 118:20
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Tidskriftsartikel (refereegranskat)abstract
- Organic photovoltaics with the properties of flexibility, portability, and printability are ideal candidates for low-power-consumption electronics such as the Internet of Things under indoor light conditions. In this work, an all solution-processed integrated photocapacitor (IPC) consisting of an organic photovoltaic module (OPVM) and an asymmetric super-capacitor (ASC) is demonstrated. The OPVM poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b ]dithiophene)-co-(1,3-di(5-thiophene-2-yl)-5,7-bis(2-ethylhexyl)benzo[1, 2-c:4,5-c ]dithiophene-4,8-dione)] (PBDB-T) : 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2 ,3 d ]-s-indaceno[1,2-b:5,6-b-]-dithiophene (ITIC) with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) as the top electrode delivers a high power conversion efficiency of 6.7% with a voltage of 4.3 V (1 Sun). The ASC based on PEDOT:PSS and Ti3C2Tx electrodes shows a wide operation window of 1.5 V in the aqueous electrolyte with a high energy density of 28.7 mu W h cm(-2). Consequently, the IPC achieves a high output voltage of 3 V and outstanding overall efficiency of 6.0% (45 000 lx), which shows excellent stability as the solar-charging power unit under room light (500 lx). Synergizing energy harvest and storage in a solution-processed robust, lightweight, low-cost organic IPC enables this solar-charging power unit wide potential applications in low-power-consumption portable electronics.
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| 22. |
- Kanoni, Stavroula, et al.
(författare)
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
- 2022
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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| 23. |
- Li, Mian, et al.
(författare)
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Halogenated Ti3C2 MXenes with Electrochemically Active Terminals for High-Performance Zinc Ion Batteries
- 2021
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Ingår i: ACS Nano. - : AMER CHEMICAL SOC. - 1936-0851 .- 1936-086X. ; 15:1, s. 1077-1085
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Tidskriftsartikel (refereegranskat)abstract
- The class of two-dimensional metal carbides and nitrides known as MXenes offer a distinct manner of property tailoring for a wide range of applications. The ability to tune the surface chemistry for expanding the property space of MXenes is thus an important topic, although experimental exploration of surface terminals remains a challenge. Here, we synthesized Ti3C2 MXene with unitary, binary, and ternary halogen terminals, e.g., -Cl, -Br, -I, -BrI, and -ClBrI, to investigate the effect of surface chemistry on the properties of MXenes. The electrochemical activity of Br and I elements results in the extraordinary electrochemical performance of the MXenes as cathodes for aqueous zinc ion batteries. The -Br- and -I-containing MXenes, e.g., Ti3C2Br2 and Ti3C2I2, exhibit distinct discharge platforms with considerable capacities of 97.6 and 135 mA.g(-1). Ti3C2 (BrI) and Ti3C2 (ClBrI) exhibit dual discharge platforms with capacities of 117.2 and 106.7 mAh.g(-1). In contrast, the previously discovered MXenes Ti3C2Cl2 and Ti3C2 (OF) exhibit no discharge platforms and only similar to 50% of capacities and energy densities of Ti3C2Br2. These results emphasize the effectiveness of the Lewis-acidic-melt etching route for tuning the surface chemistry of MXenes and also show promise for expanding the MXene family toward various applications.
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| 24. |
- Li, Shuixing, et al.
(författare)
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Asymmetric Electron Acceptors for High-Efficiency and Low-Energy-Loss Organic Photovoltaics
- 2020
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Ingår i: Advanced Materials. - : WILEY-V C H VERLAG GMBH. - 0935-9648 .- 1521-4095. ; 32
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Tidskriftsartikel (refereegranskat)abstract
- Low energy loss and efficient charge separation under small driving forces are the prerequisites for realizing high power conversion efficiency (PCE) in organic photovoltaics (OPVs). Here, a new molecular design of nonfullerene acceptors (NFAs) is proposed to address above two issues simultaneously by introducing asymmetric terminals. Two NFAs, BTP-S1 and BTP-S2, are constructed by introducing halogenated indandione (A(1)) and 3-dicyanomethylene-1-indanone (A(2)) as two different conjugated terminals on the central fused core (D), wherein they share the same backbone as well-known NFA Y6, but at different terminals. Such asymmetric NFAs with A(1)-D-A(2) structure exhibit superior photovoltaic properties when blended with polymer donor PM6. Energy loss analysis reveals that asymmetric molecule BTP-S2 with six chlorine atoms attached at the terminals enables the corresponding devices to give an outstanding electroluminescence quantum efficiency of 2.3 x 10(-2)%, one order of magnitude higher than devices based on symmetric Y6 (4.4 x 10(-3)%), thus significantly lowering the nonradiative loss and energy loss of the corresponding devices. Besides, asymmetric BTP-S1 and BTP-S2 with multiple halogen atoms at the terminals exhibit fast hole transfer to the donor PM6. As a result, OPVs based on the PM6:BTP-S2 blend realize a PCE of 16.37%, higher than that (15.79%) of PM6:Y6-based OPVs. A further optimization of the ternary blend (PM6:Y6:BTP-S2) results in a best PCE of 17.43%, which is among the highest efficiencies for single-junction OPVs. This work provides an effective approach to simultaneously lower the energy loss and promote the charge separation of OPVs by molecular design strategy.
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| 25. |
- Li, Wenting, et al.
(författare)
-
Recent progress in silver nanowire networks for flexible organic electronics
- 2020
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Ingår i: Journal of Materials Chemistry C. - : ROYAL SOC CHEMISTRY. - 2050-7526 .- 2050-7534. ; 8:14, s. 4636-4674
-
Forskningsöversikt (refereegranskat)abstract
- Recently, flexible transparent electrodes (FTEs) have attracted extensive attention as an essential element for future organic electronics (OEs), i.e. solution-processable, scalable and flexible organic electronics (FOEs). Although the traditional transparent electrode indium tin oxide (ITO) has been widely used in OEs, its brittleness and high cost significantly limit its application in the next generation of devices, typically flexible electronics. Thus, many alternatives, such as graphene, carbon nanotubes, conductive polymers, metal nanowires, metal grids and electrospun metallic nanofibers, have arisen at the forefront of FTEs. Among them, silver nanowire (AgNW) networks have attracted particular attention due to their excellent electrical conductivity and high transmittance, as well as facile availability and low cost. Since many studies on AgNWs have been published, a comprehensive review highlighting the advantages of AgNWs in FOEs is highly required. In this review, the synthesis and film fabrication of AgNWs have been firstly summarized, focusing especially on the properties of conductivity and light transmittance. Next, post treatments with different approaches to improve the conductivity of AgNWs have been included. And then, characterization of FTEs has been introduced with details on key parameters for FOEs. Furthermore, AgNW-based FOEs have been summarized to demonstrate the recent progress, such as organic light-emitting diodes (OLEDs), organic solar cells (OSCs), light-emitting electrochemical cells (LECs), organic field effect transistors (OFETs), organic memory devices (OMDs), etc. Finally, perspectives for AgNWs in FOEs have been discussed and concluded as well. It is expected that AgNWs could be the focus of future FOEs compared with other alternatives in terms of their advantages of optoelectronic properties, film-formation, solution-processability and flexibility.
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| 26. |
- Liu, H., et al.
(författare)
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Distribution of heavy metal resistant bacterial community succession in cow manure biochar amended sheep manure compost
- 2021
-
Ingår i: Bioresource Technology. - : Elsevier. - 0960-8524 .- 1873-2976. ; 335
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this investigation was to study the effects of cow manure biochar (CMB) on the distribution of heavy metal resistant bacterial (HMRB) community succession during sheep manure (SM) composting. The experiments were conducted with six different ratio of CMB (0%(T1), 2.5%(T2), 5%(T3), 7.5%(T4), 10%(T5) and 12% (T6) on a dry weight basis) and 0% is used as control. The results showed that the most dominant phylum were Proteobacteria (40.89%-5.65%) and Firmicutes (0.16%-93.18%), and 7.5% CMB mixed with sheep manure for best results. Thus, significant correlation was noticed among the analyzed physicochemical factors, gaseous emission and bacterial phylum in used 7.5–10% CMB applied for SM composting. Overall, the application of biochar increased the diversity of the bacterial community and promoted the degradation of organic matter. In addition, 7.5–10% CMB applied treatments showed greater immobilization of HMRB community succession during SM composting.
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| 27. |
- Liu, H., et al.
(författare)
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Sustainable blueberry waste recycling towards biorefinery strategy and circular bioeconomy : A review
- 2021
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Ingår i: Bioresource Technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 332
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Forskningsöversikt (refereegranskat)abstract
- Waste valorization using biological methods for value addition as well as environmental management is becoming popular approach for sustainable development. The present review addresses the availability of blueberry crop residues (BCR), applications of this feedstock in bioprocess for obtaining range of value-added products, to offer economic viability, business development and market potential, challenges and future perspectives. To the best of our knowledge, this is the first article addressing the blueberry waste valorization for a sustainable circular bioeconomy. Furthermore, it covers the information on the alternative BCR valorization methods and production of biochar for environmental management through removal or mitigation of organic and inorganic pollutants from contaminated sites. The review also discusses the ample opportunities of strategic utilization of BCR to offer solutions for environmental sustenance, covers the emerging trends to produce multi-products and techno-economic prospective for sustainable agronomy.
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| 28. |
- Liu, Yi, et al.
(författare)
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Impacts of anemometer changes, site relocations and processing methods on wind speed trends in China
- 2024
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Ingår i: Atmospheric Measurement Techniques. - 1867-1381 .- 1867-8548. ; 17, s. 1123-1131
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Tidskriftsartikel (refereegranskat)abstract
- In situ surface wind observation is a critical meteorological data source for various research fields. However, data quality is affected by factors such as surface friction changes, station relocations and anemometer updates. Previous methods to address discontinuities have been insufficient, and processing methods have not always adhered to World Meteorological Organization (WMO) World Climate Programme guidelines. We analyzed data discontinuity caused by anemometer changes and station relocations in China's daily in situ near-surface (1/410m) wind speed observations and the impact of the processing methods on wind speed trends. By comparing the wind speed discontinuities with the recorded location changes, we identified 90 stations that showed abnormally increasing wind speeds due to relocation. After removing those stations, we followed a standard quality control method recommended by the World Meteorological Organization to improve the data reliability and applied Thiessen polygons to calculate the area-weighted average wind speed. The result shows that China's recent reversal of wind speed was reduced by 41% after removing the problematic stations, with an increasing trend of 0.017ms-1yr-1 (R2Combining double low line0.64, P<0.05), emphasizing the importance of robust quality control and homogenization protocols in wind trend assessments.
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| 29. |
- Lu, Shen-ning, et al.
(författare)
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Application of an innovative grid-based surveillance strategy to ensure elimination and prevent reintroduction of malaria in high-risk border communities in China
- 2022
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Ingår i: BMC Public Health. - : Springer Nature. - 1471-2458. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Grid management is a grassroots governance strategy widely implemented in China since 2004 to improve the government's efficiency to actively find and solve problems among populated regions. A grid-based strategy surveillancing high-risk groups, including mobile and migrant populations (MMPs), in the China-Myanmar border region has played an indispensable role in promoting and consolidating the malaria elimination efforts by tracking and timely identification of potential importation or re-establishment of malaria among MMPs. A sequential mixed methods was implementated to explore the operational mechanism and best practices of the grid-based strategy including through the focus group discussions (FGDs), comparison of before and after the implementation of a grid-based strategy in the field sites, and data collection from the local health system.This paper distills the implementation mechanism and highlights the role of the grid-based strategy in the elimination and prevention of re-establishment of malaria transmission.
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| 30. |
- Ma, Xin, et al.
(författare)
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[CH3NH3][M(HCOO)3]-based 2D porous NiCo2S4 nanosheets for high-performance supercapacitors with high power densities
- 2022
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Ingår i: Chemical Engineering Journal. - : Elsevier. - 1385-8947 .- 1873-3212. ; 437
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Tidskriftsartikel (refereegranskat)abstract
- Cost-effective and high-performance electrode materials for energy storage and conversion are essential for commercial applications. In this work, the influence of solvent on the morphologies of [CH3NH3][M(HCOO)3] precursors was studied to design and synthesize two-dimensional (2D) porous NiCo2S4 nanosheets with different structures. As an electrode material for supercapacitors, Microflower-NiCo2S4 exhibits excellent capacitance (1,141 F g−1 at 1 A g−1) and stability (88.2% of initial capacitance maintained after 5,000 cycles at 5 A g−1). Moreover, an asymmetric capacitor was constructed using Microflower-NiCo2S4 and porous carbon (PC) and demonstrated an energy density of 51.25 Wh kg−1 at a power density of 397.5 W kg−1. When two Microflower-NiCo2S4//PC asymmetric supercapacitors were assembled in series, the device supplied power for an alarm clock with dimensions of 6.1 × 6.1 cm2 for more than 32 min. Therefore, the preparation of metal sulfides and metal oxides with hollow structures using a [CH3NH3][M(HCOO)3]-template has potential applications in energy storage and conversion.
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| 31. |
- Nie, Shisong, et al.
(författare)
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High Conductivity, Semiconducting, and Metallic PEDOT:PSS Electrode for All-Plastic Solar Cells
- 2023
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 28:6
-
Tidskriftsartikel (refereegranskat)abstract
- Plastic electrodes are desirable for the rapid development of flexible organic electronics. In this article, a plastic electrode has been prepared by employing traditional conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and plastic substrate polyethersulfone (PES). The completed electrode (Denote as HC-PEDOT:PSS) treated by 80% concentrated sulfuric acid (H2SO4) possesses a high electrical conductivity of over 2673 S/cm and a high transmittance of over 90% at 550 nm. The high conductivity is attributed to the regular arrangement of PEDOT molecules, which has been proved by the X-ray diffraction characterization. Temperature-dependent conductivity measurement reveals that the HC-PEDOT:PSS possesses both semiconducting and metallic properties. The binding force and effects between the PEDOT and PEI are investigated in detail. All plastic solar cells with a classical device structure of PES/HC-PEDOT:PSS/PEI/P3HT:ICBA/EG-PEDOT:PSS show a PCE of 4.05%. The ITO-free device with a structure of Glass/HC-PEDOT:PSS/Al4083/PM6:Y6/PDINO/Ag delivers an open-circuit voltage (V-OC) of 0.81 V, short-circuit current (J(SC) ) of 23.5 mA/cm(2), fill factor (FF) of 0.67 and a moderate power conversion efficiency (PCE) of 12.8%. The above results demonstrate the HC-PEDOT:PSS electrode is a promising candidate for all-plastic solar cells and ITO-free organic solar cells.
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| 32. |
- Prakash, Abhay, et al.
(författare)
-
A nested high-resolution unstructured grid 3-D ocean-sea ice-ice shelf setup for numerical investigations of the Petermann ice shelf and fjord
- 2022
-
Ingår i: MethodsX. - : Elsevier BV. - 1258-780X .- 2215-0161. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Three-dimensional numerical simulation of circulation in fjords hosting marine-terminating ice shelves is challenging because of the complexity of processes involved in such environments. This often requires a comprehensive model setup. The following elements are needed: bathymetry (usually unknown beneath the glacier tongue), ice shelf draft (impacting water column thickness), oceanographic state (including tidal elevation, salinity, temperature and velocity of the water masses), sea ice and atmospheric forcing. Moreover, a high spatial resolution is needed, at least locally, which may be augmented with a coarser and computationally cheaper (nested) model that provides sufficiently realistic conditions at the boundaries. Here, we describe procedures to systematically create such a setup that uses the Finite Volume Community Ocean Model (FVCOM) for the Petermann Fjord, Northwest Greenland. The first simulations are validated against temperature and salinity observations from the Petermann Fjord in September 2019. We provide•Complete bathymetry, ice-draft and water column thickness datasets of the Petermann Fjord, with an improved representation of the topography underneath the glacier tongue.•Boundary conditions for ocean, atmosphere and sea ice derived from a suite of high-resolution regional models that can be used to initialize and run the regional ocean model with realistic geophysical settings.
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| 33. |
- Prakash, Abhay, et al.
(författare)
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Impact of the Nares Strait sea ice arches on the long-term stability of the Petermann Glacier Ice Shelf
- 2024
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- One of the last remaining Greenland Ice Sheet (GrIS) glaciers featuring a floating tongue – the Petermann Glacier Ice Shelf (PGIS) is seasonally shielded by the formation of sea ice arches in the Nares Strait. However, continued decline of the Arctic sea ice extent and thickness suggest that arch formation is likely to become anomalous, necessitating an investigation into the response of PGIS to a year round mobile and thin sea ice cover. We use a high-resolution 3-D ocean-sea ice-ice shelf setup featuring an improved sub-ice shelf bathymetry and a realistic PGIS geometry, to investigate in unprecedented detail, the implications of transitions in the Nares Strait sea ice regime; from Thick Landfast to Thick Mobile and Thin Mobile, on the PGIS basal melt. Across all three regimes, basal melting increases occur during summer, and under the deeper (> 250 m) regions of the ice shelf. Diagnosing this variability via melt rate drivers suggest that a higher thermal driving under the deeper regions causes higher melt rates, which, as a secondary effect, increases the friction velocity slightly downstream. The increased meltwater production and a stronger melt overturning in the PGIS cavity deliver more meltwater from depth to the shallower regions which lowers the thermal driving and basal melt in these regions; with the winter season showing a converse pattern. Modulations in surface forcing under a mobile and thin sea ice cover act to enhance the heat transport in the cavity, enhancing the thermal driving and friction velocity at the ice shelf base, and thereby, the basal melt. Thermodynamically, under mobile sea ice, wind upwelled Atlantic Water (AW) from the Nares Strait enter the cavity. Additionally, when sea ice thins, convective overturning drives further upwelling of AW in winter. Mechanically, wind driven inflow intensifies, and is most pronounced under a (negligibly thin) mobile summer sea ice cover; and where it acts in concert with the stronger melt overturning to enhance the friction velocity which predominantly drives the basal melt under the deeper regions. These results suggest that the projected continuation of the warming of the Arctic Ocean until the end of the 21st century and the decline in Arctic sea ice extent and thickness will amplify the basal melt, impacting the long term stability of the Petermann Glacier and its contribution to the future GrIS mass loss and sea level rise.
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| 34. |
- Qin, L., et al.
(författare)
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ANA-hash table sorting algorithm for curve objects in WEDM CAM
- 2020
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Ingår i: Procedia CIRP. - : Elsevier B.V.. - 2212-8271. ; , s. 371-376
-
Konferensbidrag (refereegranskat)abstract
- Converting tool path geometries of a computer-aided design (CAD) file to computerized numerical control (CNC) commands is the core functionality of a computer aided manufacturing (CAM) software for wire electrical discharge machining (WEDM). The number of curve objects (such as lines and arcs) for a complex tool path can reach more than 20000. However, curve objects in a CAD file are sorted by drawing sequence instead of processing sequence, and slow sorting will cause an increase in elapsed time (more than 120 seconds accordingly) and a hanging consequence to the running of the embedded CNC system. Finding adjacencies of curve objects is a key step in curve sequence sorting. Conventional algorithms targeted at adjacencies traverse all vertexes of CAD files, whose complexity is O(n2). According to the characteristics of a WEDM processing path, Ana-Hash Table Sorting algorithm is proposed to reduce the elapsed sorting time. This algorithm classifies vertexes into corresponding buckets in advance according to the coordinates, and adjacencies are judged among specific buckets, so that most useless traversals can be avoided. The complexity of the algorithm is O(nlogn). Noticing that the sorting acceleration ratio varies widely in table parameters, the optimization of table generating rules is given. The proposed algorithm works efficiently when the number of buckets per row is 1% to 1.5% of the number of curve objects. And the elapsed sorting time can be dramatically reduced by 99% as compared to the conventional traversal algorithm.
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| 35. |
- Qin, S., et al.
(författare)
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Fungal dynamics during anaerobic digestion of sewage sludge combined with food waste at high organic loading rates in immersed membrane bioreactors
- 2021
-
Ingår i: Bioresource Technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 335
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, the influence of distinct hydraulic retention times (HRT) and organic loading rates (OLRs) on fungal dynamics during food waste anaerobic digestion in immersed membrane-based bio-reactors (iMBR) were investigated. The organic loading rate 4–8 g VS/L/d (R1) and 6–10 g VS/L/d (R2) were set in two iMBR. T1 (1d), T2 (15d) and T3 (34d) samples collected from each bioreactor were analyzed fungal community by using 18s rDNA. In R2, T2 had the most abundant Ascomycota, Basidiomycota, Chytridiomycota and Mucoromycota. As for R1, T3 also had the richest Cryptomycota except above four kinds of fungi. Subsequently, the Principal Component Analysis (PCA) and Non-Metric Multi-Dimensional Scaling (NMDS) indicated that fungal diversity was varied among the all three phases (T1, T2, and T3) and each treatment (R1 and R2). Finally, the results showed that different OLRs and HRT have significantly influenced the fungal community.
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| 36. |
- Tang, Tingfan, et al.
(författare)
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Sensitive and selective electrochemical determination of uric acid in urine based on ultrasmall iron oxide nanoparticles decorated urchin-like nitrogen-doped carbon
- 2022
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Ingår i: Colloids and Surfaces B. - : Elsevier. - 0927-7765 .- 1873-4367. ; 216
-
Tidskriftsartikel (refereegranskat)abstract
- Hypercrosslinked pyrrole was synthesized via the Friedel–Crafts reaction and then carbonized to obtain urchin-like nitrogen-doped carbon (UNC). Ultrasmall iron oxide nanoparticles were then supported on UNC, and the composite was used to prepare an electrochemical sensor for detecting uric acid (UA) in human urine. FexOy/UNC was characterized and analyzed via scanning electron microscopy, transmission electron microscopy, energy dispersive spectrometry, X-ray diffraction, and X-ray photoelectron spectroscopy. A glassy carbon electrode (GCE) modified with FexOy/UNC was used as an electrochemical sensor to effectively identify UA. The electrochemical behavior of the FexOy/UNC-based UA sensor was studied using differential pulse stripping voltammetry, and the optimal conditions were determined by changing the amount of FexOy/UNC, pH of the buffer solution, deposition potential, and deposition time. Under optimal conditions, the FexOy/UNC-based electrochemical sensor detected UA in the range of 2–200 μM, where the limit of detection (LOD) for UA was 0.29 μM. Anti-interference experiments were performed, and the sensor was applied to the actual analysis of human urine samples. Urea, glucose, ascorbic acid, and many cations and anions present at 100-fold concentrations relative to UA did not strongly interfere with the response of the sensor to UA. The FexOy/UNC electrochemical sensor has high sensitivity and selectivity for uric acid in human urine samples and can be used for actual clinical testing of UA in urine.
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| 37. |
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| 38. |
- Tsai, Cheng Ying, et al.
(författare)
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Theoretical formulation of phase space microbunching instability in the presence of intrabeam scattering for single-pass or recirculation accelerators
- 2020
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Ingår i: Physical Review Accelerators and Beams. - 2469-9888. ; 23:12
-
Tidskriftsartikel (refereegranskat)abstract
- Microbunching instability (MBI) has been one of the most challenging issues in designs of high-brightness beam transport lines for single-pass or recirculating accelerators. Although the intrabeam scattering (IBS) has long been studied in lepton or hadron storage rings as a slow diffusion process or in high-intensity proton linear accelerators as one mechanism for the beam halo, the effects of IBS on single-pass or recirculating electron accelerators have drawn attention only in the recent two decades due to emergence of linac-based or energy-recovery-linac-based fourth-generation light sources, which require high-quality electron beams during the beam transport. In this paper we develop a theoretical formulation of microbunching instability in the presence of IBS for single-pass or recirculation accelerators. To quantify MBI with inclusion of IBS, we start from the Vlasov-Fokker-Planck (VFP) equation, combining both collective interactions and incoherent IBS effects. The linearized VFP equation and the corresponding friction and diffusion coefficients are derived. The evolutions of the resultant density and energy modulations are formulated as a set of coupled integral equations. The theoretical formulation is then applied to a recirculating beamline design. The results from the semianalytical calculation are compared and show good agreement with massive particle tracking simulations.
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| 39. |
- Wang, Faming, et al.
(författare)
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Coastal blue carbon in China as a nature-based solution toward carbon neutrality
- 2023
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Ingår i: INNOVATION. - 2666-6758. ; 4:5
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Forskningsöversikt (refereegranskat)abstract
- To achieve the Paris Agreement, China pledged to become "Carbon Neutral" by the 2060s. In addition to massive decarbonization, this would require significant changes in ecosystems toward negative CO2 emissions. The ability of coastal blue carbon ecosystems (BCEs), including mangrove, salt marsh, and seagrass meadows, to sequester large amounts of CO2 makes their conservation and restoration an important "nature-based solution (NbS)" for climate adaptation and mitigation. In this review, we examine how BCEs in China can contribute to climate mitigation. On the national scale, the BCEs in China store up to 118 Tg C across a total area of 1,440,377 ha, including over 75% as unvegetated tidal flats. The annual sedimental C burial of these BCEs reaches up to 2.06 Tg C year(-1) , of which most occurs in salt marshes and tidal flats. The lateral C flux of mangroves and salt marshes contributes to 1.17 Tg C year(-1) along the Chinese coastline. Conservation and restoration of BCEs benefit climate change mitigation and provide other ecological services with a value of $32,000 ha(-1) year(-1). The potential practices and technologies that can be implemented in China to improve BCE C sequestration, including their constraints and feasibility, are also outlined. Future directions are suggested to improve blue carbon estimates on aerial extent, carbon stocks, sequestration, and mitigation potential. Restoring and preserving BCEs would be a cost-effective step to achieve Carbon Neutral by 2060 in China despite various barriers that should be removed.
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| 40. |
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| 41. |
- Wang, Shuxin, et al.
(författare)
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Buried interface modification and light outcoupling strategy for efficient blue perovskite light-emitting diodes
- 2024
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Ingår i: Science Bulletin. - : ELSEVIER. - 2095-9273. ; 69:14, s. 2231-2240
-
Tidskriftsartikel (refereegranskat)abstract
- Perovskite light-emitting diodes (PeLEDs) exhibit remarkable potential in the field of displays and solidstate lighting. However, blue PeLEDs, a key element for practical applications, still lag behind their green and red counterparts, due to a combination of strong nonradiative recombination losses and unoptimized device structures. In this report, we propose a buried interface modification strategy to address these challenges by focusing on the bottom-hole transport layer (HTL) of the PeLEDs. On the one hand, a multifunctional molecule, aminoacetic acid hydrochloride (AACl), is introduced to modify the HTL/perovskite interface to regulate the perovskite crystallization. Experimental investigations and theoretical calculations demonstrate that AACl can effectively reduce the nonradiative recombination losses in bulk perovskites by suppressing the growth of low-n perovskite phases and also the losses at the bottom interface by passivating interfacial defects. On the other hand, a self-assembly nanomesh structure is ingeniously developed within the HTLs. This nanomesh structure is meticulously crafted through the blending of poly-(9,9-dioctyl-fluorene-co-N-(4-butyl phenyl) diphenylamine) and poly (n-vinyl carbazole), significantly enhancing the light outcoupling efficiency in PeLEDs. As a result, our blue PeLEDs achieve remarkable external quantum efficiencies, 20.4% at 487 nm and 12.5% at 470 nm, which are among the highest reported values. Our results offer valuable insights and effective methods for achieving high-performance blue PeLEDs. (c) 2024 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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| 42. |
- Xu, Qin, et al.
(författare)
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Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development
- 2022
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 119:6
-
Tidskriftsartikel (refereegranskat)abstract
- Oncogenic imbalance of DNA methylation is well recognized in cancer development. The ten-eleven translocation (TET) family of dioxygenases, which facilitates DNA demethylation, is frequently dysregulated in cancers. How such dysregulation contributes to tumorigenesis remains poorly understood, especially in solid tumors which present infrequent mutational incidence of TET genes. Here, we identify loss-of-function mutations of TET in 7.4% of human lung adenocarcinoma (LUAD), which frequently co-occur with oncogenic KRAS mutations, and this co-occurrence is predictive of poor survival in LUAD patients. Using an autochthonous mouse model of KrasG12D-driven LUAD, we show that individual or combinational loss of Tet genes markedly promotes tumor development. In this Kras-mutant and Tet-deficient model, the premalignant lung epithelium undergoes neoplastic reprogramming of DNA methylation and transcription, with a particular impact on Wnt signaling. Among the Wnt-associated components that undergo reprogramming, multiple canonical Wnt antagonizing genes present impaired expression arising from elevated DNA methylation, triggering aberrant activation of Wnt signaling. These impairments can be largely reversed upon the restoration of TET activity. Correspondingly, genetic depletion of beta-catenin, the transcriptional effector of Wnt signaling, substantially reverts the malignant progression of Tet-deficient LUAD. These findings reveal TET enzymes as critical epigenetic barriers against lung tumorigenesis and highlight the therapeutic vulnerability of TET-mutant lung cancer through targetingWnt signaling.
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| 43. |
- Yuan, Shuai, et al.
(författare)
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Continuous Variation of Lattice Dimensions and Pore Sizes in Metal-Organic Frameworks
- 2020
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 142:10, s. 4732-4738
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Tidskriftsartikel (refereegranskat)abstract
- The continuous variation of the lattice metric in metal-organic frameworks (MOFs) allows precise control over their chemical and physical properties. This has been realized herein by a series of mixed-linker and Zr-6-cluster-based MOFs, namely, continuously variable MOFs (CVMOFs). Similar to the substitutional solid solutions, organic linkers with different lengths and various ratios were homogeneously incorporated into a framework rather than being allowed to form separate phases or domains, which was manifested by single-crystal X-ray diffraction, powder X-ray diffraction, fluorescence quenching experiments, and molecular simulations. The unit cell dimension, surface area, and pore size of CVMOFs were precisely controlled by adopting different linker sets and linker ratios. We demonstrate that CVMOFs allow the continuous and fine tailoring of cell-edge lengths from 17.83 to 32.63 angstrom, Brunauer-Emmett-Teller (BET) surface areas from 585 to 3791 m(2)g(-1), and pore sizes up to 15.9 angstrom. Furthermore, this synthetic strategy can be applied to other MOF systems with various metal nodes thus allowing for a variety of CVMOFs with unprecedented tunability.
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| 44. |
- Zhang, Huai, et al.
(författare)
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease.
- 2024
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Ingår i: Hepatology international. - 1936-0541.
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Tidskriftsartikel (refereegranskat)abstract
- With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p=0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.
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| 45. |
- Zhang, Juqing, et al.
(författare)
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Super-enhancers conserved within placental mammals maintain stem cell pluripotency
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 119:40
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Tidskriftsartikel (refereegranskat)abstract
- Despite pluripotent stem cells sharing key transcription factors, their maintenance involves distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can function as master regulatory hubs to control cell identity and pluripotency in humans and mice. However, whether pluripotency-associated SEs share an evolutionary origin in mammals remains elusive. Here, we performed comprehensive comparative epigenomic and transcription factor binding analyses among pigs, humans, and mice to identify pluripotency-associated SEs. Like typical enhancers, SEs displayed rapid evolu-tion in mammals. We showed that BRD4 is an essential and conserved activator for mammalian pluripotency-associated SEs. Comparative motif enrichment analysis revealed 30 shared transcription factor binding motifs among the three species. The majority of transcriptional factors that bind to identified motifs are known regulators associated with pluripotency. Further, we discovered three pluripotency-associated SEs (SE-SOX2, SE-PIM1, and SE-FGFR1) that displayed remarkable conservation in pla-cental mammals and were sufficient to drive reporter gene expression in a pluripotency-dependent manner. Disruption of these conserved SEs through the CRISPR-Cas9 approach severely impaired stem cell pluripotency. Our study provides insights into the understanding of conserved regulatory mechanisms underlying the maintenance of plu-ripotency as well as species-specific modulation of the pluripotency-associated regula-tory networks in mammals.
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| 46. |
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| 47. |
- Zhou, Guanqun, et al.
(författare)
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Two-stage reflective self-seeding scheme for high-repetition-rate X-ray free-electron lasers
- 2021
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Ingår i: Journal of Synchrotron Radiation. - 0909-0495. ; 28, s. 44-51
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Tidskriftsartikel (refereegranskat)abstract
- X-ray free-electron lasers (XFELs) open a new era of X-ray based research by generating extremely intense X-ray flashes. To further improve the spectrum brightness, a self-seeding FEL scheme has been developed and demonstrated experimentally. As the next step, new-generation FELs with high repetition rates are being designed, built and commissioned around the world. A high repetition rate would significantly speed up the scientific research; however, alongside this improvement comes new challenges surrounding thermal management of the self-seeding monochromator. In this paper, a new configuration for self-seeding FELs is proposed, operated under a high repetition rate which can strongly suppress the thermal effects on the monochromator and provides a narrow-bandwidth FEL pulse. Three-dimension time-dependent simulations have been performed to demonstrate this idea. With this proposed configuration, high-repetition-rate XFEL facilities are able to generate narrow-bandwidth X-ray pulses without obvious thermal concern on the monochromators.
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| 48. |
- Zhou, Lihua, et al.
(författare)
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Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
- 2023
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Ingår i: Nursing Open. - : Wiley. - 2054-1058. ; 10:2, s. 630-640
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Tidskriftsartikel (refereegranskat)abstract
- Aim:The aim of this study was to explore the factors that are associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer. Design:A cross-sectional descriptive study. Methods:A convenience sample of 312 spouses of women diagnosed with gynaecological cancer was recruited from two comprehensive hospitals in China, from March 2018 to March 2020. Demographic characteristics, cancer-related characteristics, posttraumatic growth, perceived social support and coping were assessed using self-reported questionnaires. Descriptive statistics and multiple linear regression analysis were performed. The methods were guided by the STROBE checklist. Results:The mean score of posttraumatic growth was 46.7 (standard deviation = 16.7). The associated factors of posttraumatic growth were spouses' age, perceived social support, problem-focused coping, dysfunctional coping (e.g. denial) and cancer treatment received by partners, which accounted for 34% of total posttraumatic growth score. Patient or public contribution:All participants contributed to the conducting of this study by completing self-reported questionnaires.
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| 49. |
- Zhou, Menglin, et al.
(författare)
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Hematite nanoparticle decorated MIL-100 for the highly selective and sensitive electrochemical detection of trace-level paraquat in milk and honey
- 2023
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 376
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Tidskriftsartikel (refereegranskat)abstract
- An octahedral metal-organic framework, MIL-100, was synthesized by a hydrothermal method followed by high-temperature calcination. Thereafter, hematite nanoparticles were assembled on its surface to form Fe2O3-MIL-100, which was used to develop an electrochemical sensor for the sensitive detection of paraquat (PQ). The Fe2O3-MIL-100-based electrochemical sensor showed appreciable sensing performance under optimized conditions, with a linear response in the range of 0.01–30 μM and a limit of detection of 2.6 nM. The Fe2O3-MIL-100-based electrode produced an excellent current response to PQ even after 20 d of storage. Notably, the Fe2O3-MIL-100-based electrochemical sensor exhibited high sensitivity and selectivity for PQ detection in milk and honey samples. Therefore, the fabricated sensor can be an effective tool for the rapid detection of PQ in foods.
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| 50. |
- Zhou, R., et al.
(författare)
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Maritime Disruption Impact Evaluation Using Simulation and Big Data Analytics
- 2022
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Ingår i: Proceedings - Winter Simulation Conference. - : Institute of Electrical and Electronics Engineers Inc.. - 9798350309713 ; , s. 784-795
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Konferensbidrag (refereegranskat)abstract
- Disruptions in maritime networks may cause significant financial burden and damage to business. Recently, some international ports have been experiencing unprecedented congestions due to the COVID19 pandemic and other disruptions. It is paramount for the maritime industry to further enhance the capability to assess and predict impacts of disruptions. With more data available from industrial digitization and more advanced technologies developed for big data analytics and simulation, it is possible to build up such capability. In this study, we developed a discrete event simulation model backed with big data analytics for realistic and valid inputs to assess impacts of the Suez Canal blockage to the Port of Singapore. The simulation results reveal an interesting finding that, the blockage occurred in the Suez Canal can hardly cause significant congestion in the Port of Singapore. The work can be extended to evaluate impacts of other types of disruptions, even occurring concurrently.
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