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The role of placent...
The role of placental exosomes in reproduction
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- Mincheva-Nilsson, Lucia, 1951- (author)
- Umeå universitet,Klinisk immunologi
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- Baranov, Vladimir, 1940- (author)
- Umeå universitet,Klinisk immunologi
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(creator_code:org_t)
- 2010-03-11
- 2010
- English.
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In: American Journal of Reproductive Immunology and Microbiology. - : Wiley. - 8755-8920 .- 1046-7408 .- 1600-0897. ; 63:6, s. 520-533
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Abstract
Subject headings
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- Cell communication comprises cell-cell contact, soluble mediators and intercellular nanotubes. There is, however, another cell-cell communication by released membrane-bound microvesicles that convey cell-cell contact 'by proxy' transporting signals/packages of information from donor to recipient cells locally and/or at a distance. The nanosized exosomes comprise a specialized type of microvesicles generated within multivesicular bodies (MVB) and released upon MVB fusion with the plasma membrane. Exosomes are produced by a variety of immune, epithelial and tumor cells. Upon contact, exosomes transfer molecules that can render new properties and/or reprogram their recipient cells. Recently, it was discovered that the syncytiotrophoblast constitutively and throughout the pregnancy secretes exosomes. The placenta-derived exosomes are immunosuppressive and carry proteins and RNA molecules that in a redundant way influence a number of mechanisms and promote the fetal allograft survival. In this review, we summarize the current knowledge on the nature of placenta-derived exosomes and discuss their role in pregnancy.
Keyword
- Exosomes; FasL; MICA/B; microvesicles; placenta; ULBP
Publication and Content Type
- ref (subject category)
- art (subject category)
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