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- Amstadter, Ananda B., et al.
(författare)
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Testing Phenotypic Models of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity Using Longitudinal Registry Data
- 2023
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Ingår i: Journal of Studies on Alcohol and Drugs. - : Alcohol Research Documentation, Inc.. - 1937-1888 .- 1938-4114. ; 84:3, s. 378-388
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Two predominant phenotypic models of causality exist to explain the high co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD): the self-medication and susceptibility models. Population-based longitudinal studies that simultaneously examine both models are needed. Thus, the goal of the pres-ent study is to test these models using the Swedish National Registries. Method: Registries were used to conduct longitudinal Cox proportional hazard models (n ≈ 1.5 million) and cross-lagged panel models (N ≈ 3.8 million) with follow-up periods of ~23 years. Results: Covarying for cohort and socioeconomic status, Cox proportional hazards model results found strong support for the self-medication model. Results showed that PTSD predicted increased risk for AUD among both men (HR = 4.58 [4.42, 4.74]) and women (HR = 4.14 [3.99, 4.30]), significantly more so for men (interaction HR = 1.11 [1.05, 1.16]). Support was also found for the susceptibility model, although the effects were lower in magnitude than those for the self-medication model. AUD increased risk for PTSD among men (HR = 2.53 [2.47, 2.60]) and women (HR = 2.06 [2.01, 2.12]), and significantly more so for men (interaction term HR = 1.23 [1.18, 1.28]). Cross-lagged model results of simultaneously testing both models found support for bidirectionality. The PTSD-to-AUD paths and the AUD-to-PTSD paths were of modest effect for men and women. Conclusions: The results from both complementary statistical approaches demonstrate that the models of comorbidity are not mutually exclusive. Although the Cox model results evidenced more support for the self-medication pathway, the cross-lagged model results suggest that the prospective relationships between these disorders are nuanced across development. (J. Stud. Alcohol Drugs, 84, 378–388, 2023).
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- Baker, Jessica H., et al.
(författare)
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Illicit Drug Use, Cigarette Smoking, and Eating Disorder Symptoms : Associations in an Adolescent Twin Sample
- 2018
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Ingår i: Journal of Studies on Alcohol and Drugs. - : Alcohol Research Documentation. - 1937-1888 .- 1938-4114. ; 79:5, s. 720-724
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Twin studies have shown that genetic factors in part explain the established relation between alcohol use (i.e., problematic use or abuse/dependence) and eating disorder symptoms in adolescent and adult females. However, studies have yet to elucidate if there are similar shared genetic factors between other aspects of substance involvement, such as illicit drug use and repeated cigarette smoking.Method: For those sex-specific phenotypic correlations above our threshold of.20, we used a behavioral genetic design to examine potential shared genetic overlap between self-reported lifetime illicit drug use and repeated cigarette smoking and the eating disorder symptoms of drive for thinness (DT), bulimia (BU), and body dissatisfaction (BD), as assessed with the Eating Disorder Inventory-II in 16- to 17-year-old female and male twin pairs.Results: Only phenotypic correlations with illicit drug use met our threshold for twin modeling. Small to moderate genetic correlations were observed between illicit drug use and BU in both girls and boys and between illicit drug use and in girls.Conclusions: Similar etiological factors are at play in the overlap between illicit drug use and certain eating disorder symptoms in girls and boys during adolescence, such that genetic factors are important for covariance. Specifically, illicit drug use was associated with bulimia nervosa symptoms in girls and boys, which parallels previous substance use research finding a genetic overlap between alcohol use and bulimia nervosa symptoms. Future research should prospectively examine developmental trajectories to further understand the etiological overlap between substance involvement and eating disorder symptoms.
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- Burk, William J., et al.
(författare)
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Alcohol use and friendship dynamics : selection and socialization in early-, middle-, and late-adolescent peer networks
- 2012
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Ingår i: Journal of Studies on Alcohol and Drugs. - : Rutgers University. - 1937-1888 .- 1938-4114. ; 73:1, s. 89-98
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study examined developmental trends of peer selection and socialization related to friends' alcohol use in early-, middle-, and late-adolescent peer networks, with the primary goal of identifying when these mechanisms emerge, when these mechanisms exert their strongest effects, and when (or if) they decrease in importance. Gender and reciprocity are also tested as moderators of selection and socialization.Method: Cross-sequential study (three age cohorts assessed at three annual measurements) of 950 youth (53% male) initially attending classrooms in Grade 4 (n = 314; M = 10.1 years), Grade 7 (n = 335; M = 13.1 years), and Grade 10 (n = 301; M = 16.2 years).Results: Similarity between friends' drinking behaviors emerged in Grade 6, peaked in Grade 8, and decreased throughout late adolescence. Adolescents in all three age groups selected peers with similar drinking behaviors, with effects being more robust for early-adolescent males and for late-adolescent females. Peers' alcohol use emerged as a significant predictor of middle-adolescent alcohol use and remained a significant predictor of individual drinking behaviors throughout late adolescence. Socialization did not differ as a function of gender or reciprocity.Conclusions: Alcohol-related peer selection was relatively more important than socialization in early-adolescent friendship networks; both mechanisms contributed to explaining similarity between the drinking behaviors of friends in middle and late adolescence. Effects of peer socialization emerged in middle adolescence and remained throughout late adolescence. (J Stud. Alcohol Drugs, 73, 89-98, 2012)
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- Callinan, Sarah, et al.
(författare)
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Drinking Contexts and Alcohol Consumption : How Much Alcohol Is Consumed in Different Australian Locations?
- 2016
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Ingår i: Journal of Studies on Alcohol and Drugs. - : Alcohol Research Documentation, Inc.. - 1937-1888 .- 1938-4114. ; 77:4, s. 612-619
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to examine where Australians in different demographic groups and drinker categories consume their alcohol. Method: Results were taken from the Australian arm of the International Alcohol Control study, a telephone survey of 2,020 Australian adults with an oversample of risky drinkers. The 1,789 respondents who reported consuming alcohol in the past 6 months were asked detailed questions about the location of their alcohol consumption and how much alcohol they consumed at each place. Results: Sixty-three percent of all alcohol consumption reported by respondents was consumed in the drinker's own home, with much less consumed at pubs, bars, and nightclubs (12%). This is driven primarily by the number of people who drink in the home and the frequency of these events, with the amount consumed per occasion at home no more than in other people's homes or pubs, and significantly less than at special events. The average consumption on a usual occasion at each of these locations was more than five Australian standard drinks (above the Australian low-risk guideline for episodic drinking). Short-term risky drinkers had the highest proportion of consumption in pubs (19%), but they still consumed 41% of their units in their own home. Conclusions: The majority of alcohol consumed in Australia is consumed in the drinker's own home. Efforts to reduce long-term harms from drinking need to address off-premise drinking and, in particular, drinking in the home.
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