| 1. |
- Ainamo, Antti, 1963-, et al.
(författare)
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Progress in the treatment and outcome of pediatric inflammatory bowel disease patients
- 2016
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Ingår i: Expert Review of Clinical Immunology. - Borås / Helsinki : Taylor & Francis. - 1744-666X .- 1744-8409. ; , s. 1-33
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Forskningsöversikt (refereegranskat)abstract
- This review discusses how treatment of pediatric inflammatory bowel disease (IBD) patients has improved with attention to therapeutic quality and cost. The number of such patients in Western countries has increased rapidly. Similarly to what has been the trend in the management of adult IBD, the pediatric IBD therapy has become more active than earlier. High use of immunosuppressants has helped to control the extensive and aggressive course of pediatric IBD. Full disease control already at an early phase has advantages such as to preserve normal child growth and development, to maintain overall good health and quality of life, as well as to decrease the psychosocial burden of the disease. A key research direction is to develop the more active approach into a way to reduce healthcare costs by decreasing the so-far high rate of surgery of pediatric IBD patients.
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| 2. |
- Barratt, Jonathan, et al.
(författare)
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Budesonide delayed-release capsules to reduce proteinuria in adults with primary immunoglobulin A nephropathy
- 2023
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Ingår i: Expert Review of Clinical Immunology. - : Taylor & Francis. - 1744-666X .- 1744-8409. ; 19:7, s. 699-710
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionImmunoglobulin A nephropathy (IgAN) is characterized by mesangial deposition of immune complexes containing galactose-deficient IgA1 (Gd-IgA1). This Gd-IgA1 is believed to originate from mucosally sited B cells, which are abundant in the Peyer's patches-rich distal ileum. Nefecon is a targeted-release form of budesonide developed to act in the distal ileum, thereby exerting a direct action on the mucosal tissue implicated in the pathogenesis of the disease.Areas coveredThis review discusses IgAN pathophysiology and provides an overview of the current therapeutic landscape, focusing on Nefecon, the first drug to receive accelerated US approval and conditional EU approval for the treatment of patients with IgAN at risk of rapid disease progression.Expert opinionNefecon trial data thus far have demonstrated a promising efficacy profile, with a predictable pattern of adverse events. Treatment with Nefecon for 9 months reduces proteinuria substantially (Part A of the Phase 3 trial and the Phase 2b trial). A nearly complete prevention of deterioration of renal function has been observed at 12 months in patients at greatest risk of rapid disease progression. Long-term data from Part B of the Phase 3 study will provide 24-month data, furthering understanding of the durability of the 9-month treatment course.
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| 3. |
- Grunewald, J
(författare)
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HLA associations and Löfgren's syndrome
- 2012
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Ingår i: Expert review of clinical immunology. - : Informa UK Limited. - 1744-8409 .- 1744-666X. ; 8:1, s. 55-62
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Tidskriftsartikel (refereegranskat)
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| 4. |
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| 5. |
- Lu, Chan, et al.
(författare)
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Early-life exposure to air pollution and childhood allergic diseases : an update on the link and its implications.
- 2020
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Ingår i: Expert Review of Clinical Immunology. - 1744-666X .- 1744-8409. ; 16:8, s. 813-827
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Although mounting evidence has linked environmental factors with childhood allergies, some specific key issues still remain unclear: what is the main environmental factor? what is the critical timing window? And whether these contribute to the development of disease?AREAS COVERED: This selective review summarizes recent epidemiological studies on the association between early-life exposure to indoor/outdoor air pollution and childhood allergic diseases. A literature search was conducted in the PubMed and Web of Science for peer-reviewed articles published until April 2020. Exposure to the traffic-related air pollutant, NO2, exposure during pregnancy and early postnatal periods is found to be associated with childhood allergies, and exposure during different trimesters causes different allergic diseases. However, exposure to classical air pollutants (PM10 and SO2) also contributes to childhood allergy in developing countries. In addition, early-life exposure to indoor renovation and mold/dampness significantly increases the risk of allergy in children. A synergistic effect between indoor and outdoor air pollution is found in the development of allergic diseases.EXPERT OPINION: Early-life exposure to outdoor air pollution and indoor environmental factors plays an important role in the development of childhood allergic diseases, and the synergy between indoor and outdoor exposures increases allergy risk. The available findings support the hypothesis of the 'fetal origins of childhood allergy,' with new implications for the effective control and early prevention of childhood allergies.
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| 6. |
- Maeurer, M
(författare)
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Markus Maeurer on the LifeGene project
- 2010
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Ingår i: Expert review of clinical immunology. - : Informa UK Limited. - 1744-8409 .- 1744-666X. ; 6:5, s. 709-712
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Mincheva-Nilsson, Lucia, 1951-
(författare)
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Immune cells and molecules in pregnancy : friends or foes to the fetus?
- 2006
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Ingår i: Expert Review of Clinical Immunology. - : Future Drugs LTD. - 1744-666X .- 1744-8409. ; 2:3, s. 457-470
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Forskningsöversikt (refereegranskat)abstract
- Considering the allograft rejection as a basic feature of the immune system, the mammalian pregnancy is an immunologic paradox where the semiallogeneic fetus is not rejected. How are the demands of pregnancy solved in the context of the maternal immunity? Medawar`s original proposal of maternal immune inertness during pregnancy should be revised to active materno-placental tolerance. Multiple mechanisms are involved in the peripheral and local tolerance induction that prevents fetal rejection while maintaining competent immune surveillance and protection. The goal of this review is to discuss the major cellular and molecular components of the immune system during pregnancy that control and promote fetal survival.
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| 8. |
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| 9. |
- West, Christina E., et al.
(författare)
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Probiotics for treatment and primary prevention of allergic diseases and asthma : looking back and moving forward
- 2016
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Ingår i: Expert Review of Clinical Immunology. - : Taylor & Francis. - 1744-666X .- 1744-8409. ; 12:6, s. 625-639
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Forskningsöversikt (refereegranskat)abstract
- Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given -not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies.
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| 10. |
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