| 1. |
- Juhlin, Christopher, 1956-, et al.
(författare)
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Reflection seismic studies over the end-glacial Burträsk fault, Skellefteå, Sweden
- 2010
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Ingår i: Solid Earth Discussions. - : Copernicus GmbH. - 1869-9537. ; 2, s. 307-329
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Tidskriftsartikel (refereegranskat)abstract
- Reflection seismic data were acquired along a ca. 22 km long profile over the end-glacial Burträsk Fault with a nominal receiver and source spacing of 20 m. A steeply dipping reflection can be correlated to the Burträsk Fault, indicating that the fault dips at about 55° to the southeast near the surface. The reflection from the fault is rather poorly imaged, probably due to a jump in the fault and the crookedness of the seismic profile in the vicinity of the fault. A more pronounced steeply dipping reflection is observed about 4 km southeast of the Burträsk Fault. Based on its correlation with a topographic low at the surface this reflection is interpreted to originate from a fracture zone. There are no signs of large displacements along this fault as the glacial ice receded, but it may be active today. Other reflections on the processed seismic section may originate from changes in lithological variations in the supra-crustal rocks or from intrusions of more mafic rock. Constraints on the fault geometry provided by the reflection seismic data will help determine what stresses were required to activate the fault when the major rupture along it occurred.
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| 2. |
- Ravindran, P, et al.
(författare)
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Optical properties of monoclinic SnI2 from relativistic first-principles theory
- 1997
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. - 0163-1829. ; 56:11, s. 6851-6861
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Within the local-density approximation, using the relativistic full-potential linear muffin-tin orbital method, the electronic structure is calculated for the anisotropic, layered material SnI2. The direct interband transitions are calculated using the fu
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| 3. |
- Rodriguez Recio, Mariano
(författare)
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High-elevation landforms limit the movement of invasive small mammal species
- 2022
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Ingår i: Landscape Ecology. - : Springer Science and Business Media LLC. - 0921-2973 .- 1572-9761. ; 37, s. 2651-2670
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Tidskriftsartikel (refereegranskat)abstract
- Context Large-scale programs for eradication of pest mammals are confronted with the challenge of managing reinvasion. Exploiting high-elevation landscape features that naturally limit the rate of reinvasion is a strategy that is presumed to improve the success of such initiatives, however, the efficacy of doing so has not yet been investigated. Objectives We aimed to assess whether high-elevation landforms limit the movements of 10 species of invasive small mammal in New Zealand to such a degree that they could be exploited in landscape-scale eradication programmes. Methods We determined the upper elevation limits of species' distributions, and made spatial predictions based on occupancy models. We applied these in concert to a 310,000 ha area of rugged mountainous environments and identified landforms that function as dispersal barriers to each species of interest. We validated our predictions with existing presence/absence and GPS movement data, and tested our predictions of high-elevation landform barriers with the GPS movement data of a sample of European hedgehogs (Erinaceus europaeus). Results We found that the extent of barriers which limited movement ranged from widespread (5/10 species), to localised, (3/10 species) to limited (2/10 species). Our predictions of hedgehog movement barriers were strongly supported by GPS movement data of 26 hedgehogs that were tracked in the study area. Conclusions Our findings show there is enormous potential to advance landscape-scale eradication of invasive small mammals in areas adjacent to high-elevation landforms by identifying and exploiting landscape features that limit the movement of target species in the strategies of eradication programmes.
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| 4. |
- Syvänen, Stina, et al.
(författare)
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Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET
- 2006
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 32:3, s. 1134-1141
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Tidskriftsartikel (refereegranskat)abstract
- Active efflux transporters in the blood-brain barrier lower the brain concentrations of many drug molecules and endogenous substances and thus affect their central action. The objective of this investigation was to study the dynamics of the entire inhibition process of the efflux transporter P-glycoprotein (P-gp), using positron emission tomography (PET). The P-gp marker [C-11]verapamil was administered to anesthetized rats as an i.v. bolus dose followed by graded infusions via a computerized pump system to obtain a steady-state concentration of [C-11]verapamil in brain. The P-gp modulator cyclosporin A (CsA) (3, 10 and 25 mg/kg) was administered as a short bolus injection 30 min after the start of the [C-11]verapamil infusion. The CsA pharmacokinetics was studied in whole blood in a parallel group of rats. The CsA blood concentrations were used as input to model P-gp inhibition. The inhibition of P-gp was observed as a rapid increase in brain concentrations of [C-11]verapamil, with a maximum after 5, 7.5 and 17.5 min for the respective doses. The respective increases in maximal [C-11]verapamil concentrations were 1.5, 2.5 and 4 times the baseline concentration. A model in which CsA inhibited P-gp by decreasing the transport of [C-11]verapamil out from the brain resulted in the best fit. Our data suggest that it is not the CsA concentration in blood, but rather the CsA concentration in an effect compartment, probably the endothelial cells of the blood-brain barrier that is responsible for the inhibition of P-gp.
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| 5. |
- Syvänen, Stina, et al.
(författare)
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
- 2018
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Ingår i: Alzheimer's Research & Therapy. - : BIOMED CENTRAL LTD. - 1758-9193. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Background: Amyloid-beta (A beta) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer's disease (AD) Despite recent progress targeting aggregated forms of A beta, low antibody brain penetrance remains a challenge In the piesent study, we used transferrin receptor (TfR)-mediated transcytosis to facilitate brain uptake of our previously developed A beta protofibril-selective mAb158, with the aim of increasing the efficacy of immunotherapy directed toward soluble A beta protofibills. Methods: A beta protein precursor (A beta PP)-transgenic mice (tg-ArcSwe) were given a single dose of mAb158, modified for TfR-mediated transcytosis (RmAb158-scFvSDB), in companson with an equimolar dose or a tenfold higher dose of unmodified recombinant mAb158 (RmAb158) Soluble A beta protofibrills and total A beta in the brain were measured by enzyme-linked immunosorbent assay (ELISA) Brain distribution of radiolabeled antibodies was visualized by positron emission tomography (PET) and ex vivo autoiadiography. Results: ELISA analysis of Tris-buffered saline brain extracts demonstrated a 40% reduction of soluble A beta protofibrils in both RmAb158-scFv8D3- and high-dose RmAb158-treated mice, whereas there was no A beta protofibril reduction in mice treated with a low dose of RmAb158. Further, ex vivo autoradiography and PET imaging revealed diffeient brain distribution patterns of RmAb158-scFv8D3 and RmAb158, suggesting that these antibodies may affect A beta levels by different mechanisms. Conclusions: With a combination of biochemical and imaging analyses, this study demonstrates that antibodies engineered to be transported across the blood brain barrier can be used to increase the efficacy of A beta immunotherapy. This strategy may allow for decreased antibody doses and thereby reduced side effects and treatment costs.
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| 6. |
- Good, L
(författare)
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Diverse antisense mechanisms and applications
- 2003
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Ingår i: Cellular and molecular life sciences : CMLS. - : Springer Science and Business Media LLC. - 1420-682X. ; 60:5, s. 823-824
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Tidskriftsartikel (refereegranskat)
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| 7. |
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| 10. |
- Olsson Holmström, Helena, et al.
(författare)
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- 2014
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Ingår i: Proceedings of the Euromicro Conference. - : IEEE. ; , s. 9-16
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Konferensbidrag (refereegranskat)abstract
- In most software development companies the road mapping and requirements prioritization process is a complex process in which product management experiences difficulties in getting timely and accurate customer feedback. The feedback loop from customers is slow and often there is a lack of mechanisms that allow for efficient customer data collection and analysis. As a result, there is the risk that requirements prioritization becomes opinion-based rather than data-driven, and that R&D investments are made without an accurate way of continuously validating whether they correspond to customer needs. We call this phenomenon the 'open loop' problem, referring to the challenges for product management to get accurate and timely feedback from customers. To address this problem, we develop the HYPEX model (Hypothesis Experiment Data-Driven Development) that supports companies in running feature experiments to shorten customer feedback loops. We evaluate the model in three software development companies and observe how feature experiments increase the opportunity for data-driven software development.
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