| 1. |
- Aad, G., et al.
(författare)
-
- 2013
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
- Locasciulli, Anna, et al.
(författare)
-
Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT)
- 2007
-
Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 92:1, s. 11-18
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND OBJECTIVES: The treatment of acquired aplastic anemia (AA) is based on allogeneic bone marrow transplantation (BMT) and immunosuppressive therapy. The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in two sequential time periods,1991-1996 and 1997-2002. DESIGN AND METHODS: Two-thousands and seventy-nine consecutive patients with AA, classified according to first-line treatment: BMT (n=1567) or immunosuppressive therapy (n= 912), the patients for the two sequential time periods were studied. Analyses included variables related to patients, disease and transplant. RESULTS: The actuarial 10-year survival was 73% and 68% for BMT or immunosuppressive treatment, respectively (p=0.002). BMT outcome improved significantly with time (69% and 77%, p=001) for both matched sibling donor (MSD) (74% and 80%; p=0.003 ), alternative donor (38% and 65% p=0.0001), and was better in children (79% versus 68%, p<0.0001). Multivariate analysis: favorable predictors (p<0.001) were younger age, transplant beyond 1996, MSD, a short interval diagnosis-transplant , no irradiation. IS: no significant improvement over time (69% and 73% p=0.29). Survival was significantly better in children (81% versus 70%, p=0.001), especially in vSAA(83% versus 62%, p=0.0002). Combined IS was superior to single drug treatment (77% versus 62%, p=0.002). Multivariate analysis: significant predictors of survival: age > or =16 years (p=0.0009), longer interval between diagnosis -treatment (p=0.04), single drug versus combined IS (p=0.02). INTERPRETATION AND CONCLUSIONS: Outcome has improved in subsets of AA patients: those receiving first- line BMT and children with vSAA treated with IS. Age remains a major predictor for both treatments. Early intervention is associated with a significantly better outcome and is strongly recommended, whatever the first-line therapy.
|
|
| 4. |
- Shukla, Vivekanand, et al.
(författare)
-
Strain controlled electronic and transport anisotropies in two-dimensional borophene sheets
- 2018
-
Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084. ; 20:35, s. 22952-22960
-
Tidskriftsartikel (refereegranskat)abstract
- Two recent reports on realization of an elemental 2D analogue of graphene:borophene (Science, 2015, 350, 1513-1516; Nat. Chem., 2016, 8, 563-568) focus on the inherent anisotropy and directional dependence of the electronic properties of borophene polymorphs. Achieving stable 2D borophene structures may lead to some degree of strain in the system because of the substrate-lattice mismatch. We use first principles density functional theory (DFT) calculations to study the structural, electronic and transport properties of (12) and -borophene polymorphs. We verified the directional dependency and found the tunable anisotropic behavior of the transport properties in these two polymorphs. We find that strain as low as 6% brings remarkable changes in the properties of these two structures. We further investigate current-voltage (I-V) characteristics in the low bias regime after applying a strain to see how the anisotropy of the current is affected. Such observations like the sizeable tuning of transport and I-V characteristics at the expense of minimal strain suggest the suitability of 2D borophene for futuristic device applications.
|
|
| 5. |
- Hudson, Brian
(författare)
-
Professional knowledge for mathematics teaching
- 2024
-
Ingår i: Research Handbook on Curriculum and Education. - : Edward Elgar Publishing. - 9781802208535 - 9781802208542 ; , s. 292-301
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 6. |
|
|
| 7. |
- Kilkis, Siir
(författare)
-
Optimization of Heat Pump Applications for Net-Zero Exergy Buildings
- 2008
-
Ingår i: Proceedings of the 9<sup>th</sup> IEA Heat Pump Conference. - Zürich.
-
Konferensbidrag (refereegranskat)abstract
- Steering a change for global sustainability requires a new, rationale driven approach that provides guidance to reduce emissions and protect the environment. The Rational Exergy Management Model (REMM) provides the approach of balancing natural energy resources based on their useful work potential, or exergy. For the first time, REMM formulates the level of match in the supply and demand of exergy to broader impacts on CO2 emissions, which becomes very important to reduce global warming. Furthermore, its new parameter effectively shows the ways to reduce CO2 emissions that have been compounded. The application of REMM to the building sector, the largest contributor of CO2 emissions, presents examples to think beyond the present characteristics of buildings. It also shows that heat pumps must be optimized with exergy matches in combined heat and power systems to reduce compound CO2 emissions. It is expected that this approach will be put into practice to achieve carbon wedges from buildings and set a vision for net-zero exergy buildings. An analysis tool is also developed to support the educational purposes of the REMM model.
|
|
| 8. |
|
|
| 9. |
- Eberhardson, Michael, et al.
(författare)
-
Towards improved control of inflammatory bowel disease
- 2019
-
Ingår i: Scandinavian Journal of Immunology. - : John Wiley & Sons. - 0300-9475 .- 1365-3083. ; 89:3
-
Forskningsöversikt (refereegranskat)abstract
- Inflammatory bowel disease (IBD) is characterized by activation of both the innate and adaptive immune system in genetically susceptible individuals, resulting in chronic intestinal inflammation. The triggers that initiate and perpetuate this continuous inflammation are the subject of much speculation and research, although the central role of the intestinal microbiota is recognized, and is even a target for treatment in some circumstances. The mainstay of modern IBD treatment is suppression of the immune response towards as yet unspecified antigens, and conventional therapy includes corticosteroids, 5-aminosalicylic acid (5-ASA), thiopurines and methotrexate. Reducing activity of specific mediators has proven efficacious, including adhesion molecules, such as the gut-homing integrin alpha(4)beta(7) expressed on the surface of circulating immune cells, and cytokines, such as tumour necrosis factor alpha (TNF-alpha). This has been achieved using biologic agents including monoclonal antibodies. Recent discoveries in immunology and neuroscience have revealed that signals in the peripheral nervous system regulate inflammation, including levels of TNF-alpha. The understanding of the mechanisms of the neuro-immune communication involved in inflammation control in the gut is evolving, but is as yet incomplete. Clinical studies using implanted vagus nerve stimulators for treatment of IBD show encouraging results. Accordingly, the neural reflex control of inflammation is emerging as a potential therapeutic target in treatment of IBD. Here, we review current therapeutic options and neural reflex control of gut immunity in the context of intestinal inflammation.
|
|
| 10. |
|
|
