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- La Russa, M, et al.
(författare)
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Conservative management of endometrial cancer : a survey amongst European clinicians
- 2018
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Ingår i: Archives of Gynecology and Obstetrics. - : Springer Science and Business Media LLC. - 0932-0067 .- 1432-0711. ; 298, s. 373-380
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate differences and similarities in the clinical approach of young clinicians managing women with endometrial cancer (EC) conservatively.METHODS: A web-based survey was carried out. A platform of the European Network of Young Gynaecological Oncologists (ENYGO) database was used. A 38-item multiple-choice questionnaire was used to evaluate current practice in fertility-sparing management of EC. The survey covered investigations, treatment options, follow-up and management of recurrence and future family planning. Descriptive statistics were used.RESULTS: Overall, 116 out of 650 (17.84%) ENYGO members responded to the survey. In 92 (79.3%) centres, the caseload of early stage EC treated conservatively was less than 10 per year. One hundred and seven responders (93.8%) believe that treatment with progestins could be offered in grade 1 EC without myometrial invasion, but a minority would recommend it even for grade 2 tumours with no myometrial invasion or grade 1 with superficial invasion. The diagnostic tool for establishing grade of tumour was hysteroscopy with dilatation and curettage in 64 (55%) centres. Medroxyprogesterone acetate represents the most commonly prescribed progestogen (55, 47.4%). In 78 (67.2%) centres, a repeat endometrial biopsy was offered after 3 months of treatment commencement. Recurrences are treated mostly with hysterectomy (81, 69.9%) with only a small number of responders recommending to repeat progestin treatment. Lynch syndrome is a contraindication for conservative management in half of the responders (57, 49.1%). Most clinicians agree that patients should be referred promptly for assisted reproductive techniques once complete response has been achieved (68, 58.6%).CONCLUSIONS: Our study shows that conservative management is increasingly offered to women affected by early stage EC wishing to preserve their fertility. Further studies and joint registries are required to evaluate safety and effectiveness of this approach in this probably growing number of patients.
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- Lopez-Garcia, SC, et al.
(författare)
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Treatment and long-term outcome in primary distal renal tubular acidosis
- 2019
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 34:6, s. 981-991
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Tidskriftsartikel (refereegranskat)
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- Malakhatka, Elena, 1989, et al.
(författare)
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Towards Positive Energy Districts: Multi-criteria framework and Quality Assurance
- 2024
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Ingår i: IOP Conference Series: Earth and Environmental Science. - 1755-1307 .- 1755-1315. ; 1363:1
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Konferensbidrag (refereegranskat)abstract
- This research develops a multi-criteria framework and Quality Assurance checklist (QA) for Positive-Energy-Districts (PEDs). PEDs have a large potential to contribute to reach urban climate goals but require also changes of planning, development, and transformation processes of neighborhoods. Our understanding of PEDs has been broadened to include aspects of circularity and economic viability, ensuring that PED concepts not only contribute to environmental sustainability but are also economically feasible. In this enhanced perspective, Digital Twins serving as essential carriers of information and facilitators of communication, effectively bridging the gap between different dimensions of sustainable development and practical implementation and monitoring. This study is part of an ongoing European project, Digital Twin for PEDs (DT4PEDs), with Living Labs in three countries: Austria, Sweden, and Turkey. The presented study addresses the central research question, "In what phases can specific requirements be linked to the process to ensure PED development throughout the entire process using a Digital Twin?" within the context of the DT4PEDs project. Based on a participatory workshop with stakeholders from partner countries and a parallel literature review, the study encompasses three key areas. First, it seeks to consolidate property development practices across Austria, Sweden, and Turkey, including both new construction and retrofitting, into a unified framework. Second, it formulates a PED multi-criteria framework, complemented by a Quality Assurance (QA) checklist. Finally, the recommendations for digital twin are proposed to support energy related information flows and stakeholder dialogue.
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