| 1. |
- Hagberg, Hans, et al.
(författare)
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Follicular lymphoma in Sweden: nationwide improved survival in the rituximab era, particularly in elderly women: a Swedish Lymphoma Registry Study
- 2015
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 29:3, s. 668-676
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Tidskriftsartikel (refereegranskat)abstract
- Treatment for follicular lymphoma (FL) improved with rituximab. In Sweden, first-line rituximab was gradually introduced between 2003 and 2007, with regional differences. The first national guidelines for FL were published in November 2007, recommending rituximab in first-line therapy. Using the population-based Swedish Lymphoma Registry, 2641 patients diagnosed with FL from 2000 to 2010 were identified and characterized by year and region of diagnosis, age (median, 65 years), gender (50% men), first-line therapy and clinical risk factors. Overall and relative survivals were estimated by calendar periods (2000-2002, 2003-2007 and 2008-2010) and region of diagnosis. With each period, first-line rituximab use and survival increased. Survival was superior in regions where rituximab was quickly adopted and inferior where slowly adopted. These differences were independent in multivariable analyses. Ten-year relative survival for patients diagnosed 2003-2010 was 92%, 83%, 78% and 64% in the age groups 18-49, 50-59, 60-69 and ≥70, respectively. With increasing rituximab use, male sex emerged as an adverse factor. Survival improved in all patient categories, particularly in elderly women. The introduction and the establishment of rituximab have led to a nationwide improvement in FL survival. However, rituximab might be inadequately dosed in younger women and men of all ages. © 2015 Macmillan Publishers Limited. All rights reserved.
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| 2. |
- Ahlgren, Erik, 1962, et al.
(författare)
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Transport biofuels in global energy–economy modelling – a review of comprehensive energy systems assessment approaches
- 2017
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Ingår i: GCB Bioenergy. - : Wiley. - 1757-1707 .- 1757-1693. ; 9, s. 1168–1180-
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Forskningsöversikt (refereegranskat)abstract
- The high oil dependence and the growth of energy use in the transport sector have increased the interest in alternative nonfossil fuels as a measure to mitigate climate change and improve energy security. More ambitious energy and environmental targets and larger use of nonfossil energy in the transport sector increase energy–transport interactions and system effects over sector boundaries. While the stationary energy sector (e.g., electricity and heat generation) and the transport sector earlier to large degree could be considered as separate systems with limited interaction, integrated analysis approaches and assessments of energy–transport interactions now grow in importance. In recent years, the scientific literature has presented an increasing number of global energy–economy future studies based on systems modelling treating the transport sector as an integral part of the overall energy system and/or economy. Many of these studies provide important insights regarding transport biofuels. To clarify similarities and differences in approaches and results, the present work reviews studies on transport biofuels in global energy–economy modelling and investigates what future role comprehensive global energy–economy modelling studies portray for transport biofuels in terms of their potential and competitiveness. The results vary widely between the studies, but the resulting transport biofuel market shares are mainly below 40% during the entire time periods analysed. Some of the reviewed studies show higher transport biofuel market shares in the medium (15–30 years) than in the long term (above 30 years), and, in the long-term models, at the end of the modelling horizon, transport biofuels are often substituted by electric and hydrogen cars.
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| 3. |
- Bergström, Göran, et al.
(författare)
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Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis : The Swedish CardioPulmonary BioImage Study
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; , s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P<0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly. CONCLUSIONS: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
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| 4. |
- Börjesson, Martin, 1980, et al.
(författare)
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Bioenergy futures in Sweden - Modeling integration scenarios for biofuel production
- 2016
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Ingår i: Energy. - : Elsevier BV. - 0360-5442 .- 1873-6785. ; 109, s. 1026-1039
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Tidskriftsartikel (refereegranskat)abstract
- Use of bioenergy can contribute to greenhouse gas emission reductions and increased energy security. However, even though biomass is a renewable resource, the potential is limited, and efficient use of available biomass resources will become increasingly important. This paper aims to explore system interactions related to future bioenergy utilization and cost-efficient bioenergy technology choices under stringent CO2 constraints. In particular, the study investigates system effects linked to integration of advanced biofuel production with district heating and industry under different developments in the electricity sector and biomass supply system. The study is based on analysis with the MARKAL_Sweden model, which is a bottom-up, cost-optimization model covering the Swedish energy system. A time horizon to 2050 is applied. The results suggest that system integration of biofuel production has noteworthy effects on the overall system level, improves system cost-efficiency and influences parameters such as biomass price, marginal CO2 emission reduction costs and cost-efficient biofuel choices in the transport sector. In the long run and under stringent CO2 constraints, system integration of biofuel production has, however, low impact on total bioenergy use, which is largely decided by supply-related constraints, and on total transport biofuel use, which to large extent is driven by demand.
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| 5. |
- d'Amore, Francesco, et al.
(författare)
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Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma
- 2010
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 150:5, s. 565-573
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Tidskriftsartikel (refereegranskat)abstract
- The efficacy and safety of zanolimumab (HuMax-CD4) in patients with relapsed or refractory peripheral T Cell lymphoma (PTCL) was evaluated. Twenty-one adult patients with relapsed or refractory CD4+ PTCL of non-cutaneous type (angioimmunoblastic T cell lymphoma (AITL) n = 9, PTCL-not otherwise specified (NOS) n = 7, anaplastic large cell lymphoma (ALCL) n = 4 and enteropathy type T cell lymphoma n = 1) were treated in a single-arm multi-centre study, with weekly intravenous infusions of zanolimumab 980 mg for 12 weeks. Median age was 69 years (range 26-85). Seventeen of the patients had advanced stage disease (Ann Arbor stages III-IV). Objective tumour responses were obtained in 24% of the patients with two complete responses unconfirmed (CRu) and three partial responses (PR). One of the CRus lasted more than 252 d. Responses were obtained in different PTCL entities: AITL (n = 3), ALCL (n = 1) and PTCL-NOS (n = 1). In general, the trial drug was well tolerated with no major toxicity. Zanolimumab at a dose of 980 mg weekly demonstrated clinical activity and an acceptable safety profile in this poor-prognosis patient population, suggesting that the potential benefit combining zanolimumab with standard chemotherapy in the treatment of PTCL should be investigated.
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| 6. |
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| 7. |
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| 8. |
- Pulczynski, Elisa Jacobsen, et al.
(författare)
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Age-adjusted combined immunochemotherapy without radiotherapy in newly diagnosed PCNSL : A phase II trial of the Nordic Lymphoma Group
- 2011
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Ingår i: 53rd ASH Anual Meeting and Exposition. ; , s. 696-696
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Konferensbidrag (refereegranskat)abstract
- Patients and Methods: From May 2007 to October 2010, 66 newly diagnosed primary central nervous system lymphoma (PCNSL) patients (M/F ratio 1:1) were enrolled. Younger patients (≤65 yrs; N=39) received 6 three-weekly cycles of chemotherapy consisting of: high-dose (HD)-methotrexate (MTX) (cycles 1, 2, 4 and 5), HD-cytosine arabinoside (AraC) (cycles 3 and 6) in addition to Rituximab (cycle 1 only), ifosfamide (cycles 1 and 4), cyclophosphamide (cycles 2 and 5), vincristine (cycles 2 and 5), vindesine (cycles 3 and 6), and dexamethasone (all 6 cycles). Depocyte® was delivered intratechally during the HD-MTX cycles. Elderly patients (66-75 yrs; N=27) received an identical Rituximab-containing 1st cycle. Cyclophosphamide and ifosfamide were replaced by temozolamide (cycles 2 to 6), which was also given as maintenance in patients with chemosensitive disease, and vincristine was omitted. No radiotherapy was given. Response was determined after the 2nd, 4th and 6thchemotherapy cycle by cerebral MRI and assessed according to International Primary CNS Lymphoma Coordinating Group criteria. The primary endpoint was overall survival (OS), secondary endpoints were progression-free survival (PFS), overall response rate (ORR), systemic toxicity and neurotoxicity assessed as Mini Mental State Examination (MMSE) and Functional Independence Measure (FIM). Results: The median age was 64 yrs overall, 55 yrs (range 40-65) for younger and 70 yrs (range 66-75 years) for elderly patients. In 56 patients, the International Extranodal Lymphoma Study Group prognostic score was: 0-1 (N=5), 2-3 (N=36) and 4-5 (N=15). In the remaining 10 patients, lumbar puncture was not performed in five and spinal fluid protein concentration not reported in additional five cases. Response assessment after completion of induction treatment was performed in 43 out of 66 patients and showed complete remission (CR/CRu) in 30 patients, partial remission (PR) in 5 and progressive disease (PD) in 8. The ORR was 53 %. In 23 patients, response could not be evaluated due to early progression (n=8), toxic death (n=4), poor performance (n=3), neurotoxicity (n=5), or other causes (n=3). Of the 27 elderly patients, 15 continued to maintenance therapy. Of these, 14 have completed the maintenance schedule. Remission status at month 3 was CR in 13 and PD in 1 patient. With a median follow-up of 11.1 months (range 0.6-40.2) the 3-yr OS was 54.6% with no significant difference between younger and elderly patients (56.4% vs 51.9% respectively, p=0.32). The 3-yr PFS was 35.1% (32.9% in younger and 38.2 % in elderly patients; p=0.96). There were four septic deaths. Grade 3-4 hematological toxicity was seen in 79 % of the patients. Arachnoditis-like symptoms occurred in 13 patients. In all but two patients, the symptoms resolved within less than a week. MMSE and FIM were recorded both before and after therapy in 32 patients. Scores improved in 18 and 20 patients, respectively. Conclusion: In conclusion, the schedule applied in the present study led to a 3 yr PFS of 35%. Surprisingly, no significant outcome difference was found between the younger and the elderly patients. The majority of treatment failures were due to early progressive disease under induction therapy. Although the follow-up of our study is short, de-escalation of induction treatment intensity by introduction of a less toxic agent as temozolomide, and its subsequent use in a maintenance schedule may explain a possible survival benefit of this strategy in elderly patients. Disclosures: No relevant conflicts of interest to declare.
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| 9. |
- Wahlin, Björn Engelbrekt, et al.
(författare)
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T Cells in Tumors and Blood Predict Outcome in Follicular Lymphoma Treated with Rituximab
- 2011
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Ingår i: Clinical Cancer Research. - : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 17:12, s. 4136-4144
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: T cells influence outcome in follicular lymphoma, but their contributions seem to be modified by therapy. Their impact in patients receiving rituximab without chemotherapy is unknown. EXPERIMENTAL DESIGN: Using flow cytometry, we evaluated the T cells in tumors and/or blood in a total of 250 follicular lymphoma patients included in two Nordic Lymphoma Group randomized trials that compared single rituximab with IFN-α2a-rituximab combinations. RESULTS: In univariate analysis, higher levels of CD3(+), CD4(+), and CD8(+) T cells in both tumors and blood correlated with superior treatment responses, and in multivariate analysis, tumor-CD3(+) (P = 0.011) and blood-CD4(+) (P = 0.029) cells were independent. CD4(+) cells were favorable regardless of treatment arm, but CD8(+) cells were favorable only in patients treated with single rituximab, because IFN-α2a improved responses especially in patients with low CD8(+) cell levels. Higher levels of blood-CD3(+) (P = 0.003) and blood-CD4(+) (P = 0.046) cells predicted longer overall survival, and higher levels of blood-CD8(+) cells longer times to next treatment (P = 0.046). CONCLUSIONS: We conclude that therapeutic effects of rituximab are augmented by tumor-associated T cells for rapid responses and by systemic T cells for sustained responses. CD4(+) and CD8(+) cells are both favorable in patients treated with rituximab. IFN-α2a abrogates the negative impact of few CD8(+) cells.
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| 10. |
- Ameur, Adam, et al.
(författare)
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SweGen : a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- 2017
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Ingår i: European Journal of Human Genetics. - : NATURE PUBLISHING GROUP. - 1018-4813 .- 1476-5438. ; 25:11, s. 1253-1260
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Bobjer, Johannes, et al.
(författare)
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Location of retroperitoneal lymph node metastases in upper tract urothelial carcinoma : results from a prospective lymph node mapping study
- 2023
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Ingår i: European Urology Open Science. - : Elsevier. - 2666-1691 .- 2666-1683. ; 57, s. 37-44
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is limited information on the distribution of retroperitoneal lymph node metastases (LNMs) in upper tract urothelial carcinoma (UTUC).Objective: To investigate the location of LNMs in UTUC of the renal pelvis or proximal ureter and short-term complications after radical nephroureterectomy (RNU) with lymph node dissection (LND).Design, setting, and participants: This was a prospective Nordic multicenter study (four university hospitals, two county hospitals). Patients with clinically suspected locally advanced UTUC (stage >T1) and/or clinical lymph node–positive (cN+) disease were invited to participate. Participants underwent RNU and fractionated retroperitoneal LND using predefined side-specific templates.Outcome measurements and statistical analysis: The location of LNMs in the LND specimen and retroperitoneal lymph node recurrences during follow-up was recorded. Postoperative complications within 90 d of surgery were ascertained from patient charts. Descriptive statistics were used.Results and limitations: LNMs were present in the LND specimen in 23/100 patients, and nine of 100 patients experienced a retroperitoneal recurrence. Distribution per side revealed LNMs in the LND specimen in 11/38 (29%) patients with right-sided tumors, for whom the anatomically larger, right-sided template was used, in comparison to 12/62 (19%) patients with left-sided tumors, for whom a more limited template was used. High-grade complications (Clavien grade ≥3) within 90 d of surgery were registered for 13/100 patients. The study is limited in size and not powered to assess survival estimates.Conclusions: The suggested templates that we prospectively applied for right-sided and left-sided LND in patients with advanced UTUC included the majority of LNMs. High-grade complications directly related to the LND part of the surgery were limited.Patient summary: This study describes the location of lymph node metastases in patients with cancer in the upper urinary tract who underwent surgery to remove the affected kidney and ureter. The results show that most metastases occur within the template maps for lymph node surgery that we investigated, and that this surgery can be performed with few severe complications.
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| 16. |
- Dahl, Mats, et al.
(författare)
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The realism in older people's confidence judgments of answers to general knowledge questions.
- 2009
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Ingår i: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 24:1, s. 234-238
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Tidskriftsartikel (refereegranskat)abstract
- The study investigated 2 aspects of the accuracy (i.e., realism) of confidence judgments of persons age 60–93 years (N 1,384) regarding their answers to general knowledge questions. These aspects are the level of confidence (calibration) in relation to the proportion of correct answers and the ability to discriminate between correct and incorrect answers by means of confidence judgments. No age differences were found for either of the 2 aspects. Gender differences were found for proportion of correct answers and confidence but not for the realism in the confidence judgments. Keywords: aging, memory, confidence judgments, realism, general knowledge question
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| 17. |
- Dahl, Mats, et al.
(författare)
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The relation between personality and the realism in confidence judgements in older adults
- 2010
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Ingår i: European Journal of Ageing. - : Springer Science and Business Media LLC. - 1613-9372 .- 1613-9380. ; 7:4, s. 283-291
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated the relation between personality factors, as measured by the Swedish version of the NEO-FFI questionnaire, and the realism in older adults' (aged 60-93 years, n = 1,384) probability confidence judgements of their answers to general knowledge questions. The results showed very small effect sizes for the contribution of the personality variables to the fit between the proportion correct answers and the level of one's confidence judgements. Although personality differed somewhat within the age span studied and between the genders no differences were found in the relation between the dimensions of the NEO-FFI and the degree of realism in the confidence judgements as a function of age or gender. In total, the results show a significant but very small effect of personality on the realism in older adults' confidence judgements of their semantic knowledge.
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| 18. |
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| 19. |
- d'Amore, Francesco, et al.
(författare)
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Up-Front Autologous Stem-Cell Transplantation in Peripheral T-Cell Lymphoma : NLG-T-01
- 2012
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 30:25, s. 3093-3099
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Systemic peripheral T-cell lymphomas (PTCLs) respond poorly to conventional therapy. To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) in PTCL, the Nordic Lymphoma Group (NLG) conducted a large prospective phase II study in untreated systemic PTCL. This is the final report, with a 5-year median follow-up, of the NLG-T-01 study. Patients and Methods Treatment-naive patients with PTCL age 18 to 67 years (median, 57 years) were included. Anaplastic lymphoma kinase (ALK) -positive anaplastic large-cell lymphoma (ALCL) was excluded. An induction regimen of six cycles of biweekly CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone) was administered (in patients age > 60 years, etoposide was omitted). If in complete or partial remission, patients proceeded to consolidation with HDT/ASCT. Results Of 166 enrolled patients, 160 had histopathologically confirmed PTCL. The majority presented with advanced-stage disease, B symptoms, and elevated serum lactate dehydrogenase. A total of 115 underwent HDT/ASCT, with 90 in complete remission at 3 months post-transplantation. Early failures occurred in 26%. Treatment-related mortality was 4%. At 60.5 months of median follow-up, 83 patients were alive. Consolidated 5-year overall and progression-free survival (PFS) were 51% (95% CI, 43% to 59%) and 44% (95% CI, 36% to 52%), respectively. Best results were obtained in ALK-negative ALCL. Conclusion Dose-dense induction followed by HDT/ASCT was well tolerated and led to long-term PFS in 44% of treatment-naive patients with PTCL. This represents an encouraging outcome, particularly considering the high median age and adverse risk profile of the study population. Therefore, dose-dense induction and HDT/ASCT are a rational up-front strategy in transplantation-eligible patients with PTCL. J Clin Oncol 30: 3093-3099. (C) 2012 by American Society of Clinical Oncology
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| 20. |
- Edén, Arvid, 1975, et al.
(författare)
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Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.
- 2022
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Ingår i: JAMA network open. - : American Medical Association (AMA). - 2574-3805. ; 5:5
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Tidskriftsartikel (refereegranskat)abstract
- Neurologic symptoms are common in COVID-19, but the central nervous system (CNS) pathogenesis is unclear, and viral RNA is rarely detected in cerebrospinal fluid (CSF).To measure viral antigen and inflammatory biomarkers in CSF in relation to neurologic symptoms and disease severity.This cross-sectional study was performed from March 1, 2020, to June 30, 2021, in patients 18 years or older who were admitted to Sahlgrenska University Hospital, Gothenburg, Sweden, with COVID-19. All patients had CSF samples taken because of neurologic symptoms or within a study protocol. Healthy volunteer and prepandemic control groups were included.SARS-CoV-2 infection.Outcomes included CSF SARS-CoV-2 nucleocapsid antigen (N-Ag) using an ultrasensitive antigen capture immunoassay platform and CSF biomarkers of immune activation (neopterin, β2-microglobulin, and cytokines) and neuronal injury (neurofilament light protein [NfL]).Forty-four patients (median [IQR] age, 57 [48-69] years; 30 [68%] male; 26 with moderate COVID-19 and 18 with severe COVID-19 based on the World Health Organization Clinical Progression Scale), 10 healthy controls (median [IQR] age, 58 [54-60] years; 5 [50%] male), and 41 patient controls (COVID negative without evidence of CNS infection) (median [IQR] age, 59 [49-70] years; 19 [46%] male) were included in the study. Twenty-one patients were neuroasymptomatic and 23 were neurosymptomatic (21 with encephalopathy). In 31 of 35 patients for whom data were available (89%), CSF N-Ag was detected; viral RNA test results were negative in all. Nucleocapsid antigen was significantly correlated with CSF neopterin (r=0.38; P=.03) and interferon γ (r=0.42; P=.01). No differences in CSF N-Ag concentrations were found between patient groups. Patients had markedly increased CSF neopterin, β2-microglobulin, interleukin (IL) 2, IL-6, IL-10, and tumor necrosis factor α compared with controls. Neurosymptomatic patients had significantly higher median (IQR) CSF interferon γ (86 [47-172] vs 21 [17-81] fg/mL; P=.03) and had a significantly higher inflammatory biomarker profile using principal component analysis compared with neuroasymptomatic patients (0.54; 95% CI, 0.03-1.05; P=.04). Age-adjusted median (IQR) CSF NfL concentrations were higher in patients compared with controls (960 [673-1307] vs 618 [489-786] ng/L; P=.002). No differences were seen in any CSF biomarkers in moderate compared with severe disease.In this study of Swedish adults with COVID-19 infection and neurologic symptoms, compared with control participants, viral antigen was detectable in CSF and correlated with CNS immune activation. Patients with COVID-19 had signs of neuroaxonal injury, and neurosymptomatic patients had a more marked inflammatory profile that could not be attributed to differences in COVID-19 severity. These results highlight the clinical relevance of neurologic symptoms and suggest that viral components can contribute to CNS immune responses without direct viral invasion.
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| 21. |
- Elmqvist, Niklas, 1977, et al.
(författare)
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3DVN: A Mixed Reality Platform for Mobile Navigation Assistance
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We present 3DVN, a Mixed Reality platform for navigation assistance in indoor environments. Built on top of a PC-based wearable computer running the Windows operating system, the platform provides a multimodal user interface for navigating in existing physical buildings, including wireless networking, data glove gestural input, voice communication, head-mounted display, and a 3DOF head tracker. Local positioning is performed using a software-only positioning engine making use of WLAN features for accurately pinpointing the mobile device in three dimensions. The 3DVN system has been implemented as a proof-of-concept of a navigation guidance support device for visitors, and has been field-tested with human subjects in the student center of our university. Informal evaluation of subject ratings indicate a strong interest for the new system, both for guests as well as people familiar with the campus and the building.
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| 22. |
- Elmqvist, Niklas, 1977, et al.
(författare)
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3DVN: A Mixed Reality Platform for Mobile Navigation Assistance
- 2007
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Ingår i: ACM CHI2007 Workshop on Mobile Spatial Interaction. ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- We present 3DVN, a Mixed Reality platform for navigation assistance in indoor environments. Built on top of a PC-based wearable computer running the Windows operating system, the platform provides a multimodal user interface to navigate existing physical buildings, including wireless networking, data glove gestural input, voice communication, head-mounted display, and a 3DOF head tracker. Local positioning is performed using a software-only WLAN-based engine to accurately pinpoint the mobile device in three dimensions. We use this system as a platform for a simple theoretical framework for classifying interaction for mobile navigation assistance. Informal qualitative evaluation of our system seems to conform to predictions derived from our framework and shows the need for a rich set of interaction components for successful mobile navigation.
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| 23. |
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| 24. |
- Enblad, Gunilla, et al.
(författare)
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A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia
- 2018
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 24:24, s. 6185-6194
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The chimeric antigen receptor (CAR) T-cell therapy has been effective for patients with CD19(+) B-cell malignancies. Most studies have investigated the second-generation CARs with either CD28 or 4-1BB costimulatory domains in the CAR receptor. Here, we describe the first clinical phase I/IIa trial using third-generation CAR T cells targeting CD19 to evaluate safety and efficacy.Patients and Methods: Fifteen patients with B-cell lymphoma or leukemia were treated with CAR T cells. The patients with lymphoma received chemotherapy during CAR manufacture and 11 of 15 were given low-dose cyclophosphamide and fludarabine conditioning prior to CAR infusion. Peripheral blood was sampled before and at multiple time points after CAR infusion to evaluate the persistence of CAR T cells and for immune profiling, using quantitative PCR, flow cytometry, and a proteomic array.Results: Treatment with third-generation CAR T cells was generally safe with 4 patients requiring hospitalization due to adverse reactions. Six of the 15 patients had initial complete responses [4/11 lymphoma and 2/4 acute lymphoblastic leukemia (ALL)], and 3 of the patients with lymphoma were in remission at 3 months. Two patients are still alive. Best predictor of response was a good immune status prior to CAR infusion with high IL12, DC-Lamp, Fas ligand, and TRAIL. Responding patients had low monocytic myeloid-derived suppressor cells (MDSCs; CD14(+)CD33(+)HLA(-)DR(-)) and low levels of IL6, IL8, NAP3, sPDL1, and sPDL2.Conclusions: Third-generation CARs may be efficient in patients with advanced B-cell lymphoproliferative malignancy with only modest toxicity. Immune profiling pre- and posttreatment can be used to find response biomarkers.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- Hagberg, Anette, et al.
(författare)
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Gene expression analysis identifies a genetic signature potentially associated with response to alpha-IFN in chronic phase CML patients
- 2007
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Ingår i: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 31:7, s. 931-938
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Tidskriftsartikel (refereegranskat)abstract
- Microarray-based gene expression analysis was performed on diagnostic chronic phase CML patient samples prior to interferon treatment. Fifteen patient samples corresponding to six cytogenetic responders and nine non-responders were included. Genes differentially expressed between responder and non-responder patients were listed and a subsequent leave-one-out cross validation (LOOV) procedure showed that the top 20 genes allowed the highest prediction accuracy. The relevant genes were quantified by real-time PCR that supported the microarray results. We conclude that it might be possible to use gene expression analysis to predict future response to interferon in CML diagnostic samples.
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| 29. |
- Hagberg, Cecilia, et al.
(författare)
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Lättviktsgrindar av höghållfast stål för säkrare djurhantering och arbetsmiljö
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Lightweight gates of high-strength steel for improved worker safety and cattle handling This report presents the work with developing a lightweight gate of high-strength steel for the handling of cattle. The project was conducted as a European Innovation Partnership (EIP) project. The project group consisted of co-workers from the unit of Agriculture and Horticulture and the unit of Process and Environmental Engineering at Research Institutes of Sweden (RISE Jordbruk och trädgård och RISE Kretsloppsteknik), Parsteel AB (former Nilssons Plåtindustri AB), SSAB EMEA AB, Sophie Atkinson at Smart Animal Handling, Swedish University of Agricultural Sciences (SLU) in Skara and the cattle farmer Lars Olsson. The main objectives of the project were to develop a lightweight gate weighing at least 50% less and being three times as strong as a traditional gate for cattle handling. The main motive was to improve the ergonomic conditions and working environment for the animal handlers. Additionally, for the safety of both animals and handlers, the gate must withstand the loads from cattle. Other objectives were to design and construct a gate that does not exceed the price of a high-quality gate and not contribute to increased negative environmental impact. A lightweight gate can be made of various materials such as plastic, fiberglass or steel. Regarding the project group's participants and their competencies, in addition to the numerous requirements placed on a lightweight gate, the choice fell on high-strength steel. High-strength steel is characterized by having high yield strengths, up to 1300 MPa, in comparison with traditional construction steel with yield strength of 355 MPa. For the specific lightweight gate, steel pipes with a yield strength of approximately 750 MPa were chosen. These pipes are mainly used in the automotive and engine industry, where high demands are placed on strength while at the same time a light construction is desired. The gate itself was designed during the project and several details were examined and developed in regard to functionality and safety for both cattle and handlers. The work environment legislation states that gates must be dimensioned and anchored so that the animals cannot break out (AFS 2008:17). The gates must also not pose a risk of injury to the cattle. In order to work safely with cattle, knowledge of cattle behavior is essential and consequently the report contains a chapter describing cattle senses and behavior. Both the lightweight gates and the handling system, built up by the gates, must be adapted to the cattle. In the project, the bud box handling system was tested. The handling system was originally developed to make use of the behavioral characteristics of cattle to encourage forward movement in the desired direction. In the project the handling system's functionality and safety, by using lightweight gates and additional equipment and components, were further designed. The handling system was tested in two groups of heifers at the SLU Götala Beef and Lamb Research Centre. The lightweight gates were also tested in a dairy herd and a beef herd, while hoof trimming, and at a small-scale abattoir. Generally, the light weight of the gates was considered an advantage as the handling of the gates is simplified also resulting in more frequent use of the gates, increasing safety for both animals and humans. During the project, several strength tests were performed by building unique test rigs. In one test rig, the weld of the pipes of the lightweight gate was tested. In another test rig, the strength of lightweight gates, compared with traditional gates on the market, were tested. The outcome of the tests confirmed the original aim of the project, a lightweight gate made of high-strength steel, about 50% lighter and at least three times as strong as traditional gates, had been developed and designed during the project period.
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| 30. |
- Hagberg, Daniel, 1977-, et al.
(författare)
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A Light Resistant Organic Sensitizer for Solar Cell Applications
- 2009
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Ingår i: Angewandte Chemie International Edition. - Weinheim : Wiley-VCH Verlag GmbH & Co.. - 1433-7851 .- 1521-3773. ; 48, s. 1576-1580
-
Tidskriftsartikel (refereegranskat)abstract
- (Figure Presented) Finely tuned: A stable dye-sensitized solar cell that contains a molecularly engineered organic dye has been prepared. The efficiency of the cell remains at 90% after 1000 h of light soaking at 60 °C. The remarkable stability of the cell is also reflected in the open-circuit voltage value (Voc), short-circuit photocurrent-density value (J sc), and the fill factor, which also show barely no decline (see picture).
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| 31. |
- Hagberg, Daniel, 1977-, et al.
(författare)
-
Molecular Engineering of Organic Chromophores for Dye Sensitized Solar Cell Applications
- 2008
-
Ingår i: Journal of the American Chemical Society. - : ACS. - 0002-7863 .- 1520-5126. ; 130, s. 6259-6266
-
Tidskriftsartikel (refereegranskat)abstract
- Novel unsymmetrical organic sensitizers comprising donor, electron-conducting, and anchoring groups were engineered at a molecular level and synthesized for sensitization of mesoscopic titanium dioxide injection solar cells. The unsymmetrical organic sensitizers 3-(5-(4-(diphenylamino)styryl)thiophen-2-yl)-2-cyanoacrylic acid (D5), 3-(5-bis(4-(diphenylamino)styryl)thiophen-2-yl)-2-cyanoacrylic acid (D7), 5-(4-(bis(4-methoxyphenylamino)styryl)thiophen-2-yl)-2-cyanoacrylic acid (D9), and 3-(5-bis(4,4'-dimethoxydiphenylamino)styryl)thiophen-2-yl)-2-cyanoacrylic acid (D11) anchored onto TiO2 and were tested in dye-sensitized solar cell with a volatile electrolyte. The monochromatic incident photon-to-current conversion efficiency of these sensitizers is above 80%, and D11-sensitized solar cells yield a short-circuit photocurrent density of 13.90 +/- 0.2 mA/cm(2), an open-circuit voltage of 740 +/- 10 mV, and a fill factor of 0.70 +/- 0.02, corresponding to an overall conversion efficiency of 7.20% under standard AM 1.5 sun light. Detailed investigations of these sensitizers reveal that the long electron lifetime is responsible for differences in observed open-circuit potential of the cell. As an alternative to liquid electrolyte cells, a solid-state organic hole transporter is used in combination with the D9 sensitizer, which exhibited an efficiency of 3.25%. Density functional theory/time-dependent density functional theory calculations have been employed to gain insight into the electronic structure and excited states of the investigated species.
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| 32. |
- Hagberg, Daniel P., et al.
(författare)
-
Design and synthesis of organic chromophores for dye sensitized solar cells - 1
- 2008
-
Ingår i: ACS National Meeting Book of Abstracts. - 9780841269859
-
Konferensbidrag (refereegranskat)abstract
- The demand for alternative power sources has drawn the attention to a variety of light harvesting devices. Among these, the dye sensitized solar cells (DSSCxs) have attracted a number of research groups in the last decades. Here we present a series of organic chromophores based on a by us published dye, D5. To extend the spectral response of the D5 chromophore compared to N719 and to fine tune the HOMO and LUMO energy levels of the sensitizers on a molecular level, a number of modifications can be made. The chromophores consist of donor, linker and acceptor groups, which can be alternated independently to tune the HOMO and LUMO energy level contributions of different groups and to attain a HOMO and LUMO energy library.
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| 33. |
- Hagberg, Daniel P., et al.
(författare)
-
Tuning the HOMO and LUMO Energy Levels of Organic Chromophores For Dye Sensitized Solar Cells
- 2007
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; :72, s. 9550-9556
-
Tidskriftsartikel (refereegranskat)abstract
- A series of organic chromophores have been synthesized in order to approach optimal energy level composition in the TiO2-dye-iodide/triiodide system in the dye-sensitized solar cells. HOMO and LUMO energy level tuning is achieved by varying the conjugation between the triphenylamine donor and the cyanoacetic acid acceptor. This is supported by spectral and electrochemical experiments and TDDFT calculations. These results show that energetic tuning of the chromophores was successful and fulfilled the thermodynamic criteria for dye-sensitized solar cells, electrical losses depending on the size and orientation of the chromophores were observed.
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| 34. |
- Hagberg, Martin, et al.
(författare)
-
Miljövärdering av energilösningar i byggnader (etapp 2)
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Det ställs allt högre krav på byggnaders energiprestanda och i takt med detta ökar efterfrågan på miljövärdering av byggnader och deras energilösningar. I detta projekt vidareutvecklas en metodik för värdering av byggnaders energianvändning ur miljösynpunkt (metodens grundversion utvecklades i ”etapp 1” av projektet). Vi benämner metoden ”Tidstegsmetoden”. Tidstegsmetoden avser att analysera miljökonsekvenserna av byggnaders energilösningar. Metoden ska visa på effekterna av olika val och kunna ge underlag till beslut vid planering av renovering och nybyggnation. Därför är utgångspunkten att analysera systemkonsekvenser av förändrad energianvändning. Produktion av el-, fjärrvärme-, och fjärrkyla kan vara förknippade med stora skillnader i miljöpåverkan beroende på vilken tid som avses; t.ex., om det är sommar eller vinter, om det är nutid eller framtid. För att på ett representativt sätt kunna bedöma miljökonsekvensen av en förändrad energianvändning i en byggnad är därför tidsaspekten central. Den presenterade metoden hanterar därför två olika tidsdimensioner. Den ena avser den framtida utvecklingen av energisystemet – från nu och ca 20 år framåt i tiden. Den andra dimensionen är tidsupplösning över året, som avser att fånga variationer över säsonger, månader, dygn och timmar. Med konsekvens- och tidsperspektivet i fokus, inkluderar tillvägagångssättet: beräkning av byggnadens energianvändning för aktuella energiåtgärder; bestämning av miljövärdesfaktorer för en förändrad användning av bränslen, fjärrvärme, fjärrkyla och el; och beräkning miljöpåverkan av de aktuella energiåtgärderna baserat på de beräknade förändringarna i energianvändning och de fastställda miljövärdesfaktorerna. För att bättre täcka in de många osäkerheter som är förknippade med en framåtblickande analys kopplas beräkningarna till ett antal kontrasterande scenarioförutsättningar. Detta ger ett resultatspann för miljöpåverkan av de studerade energilösningarna. För att exemplifiera metoden presenteras i rapporten ett antal kvantitativa exempel. I dessa beräknas klimatpåverkan (utsläpp av CO2e) av olika energieffektiviseringsåtgärder i ett flerfamiljshus byggt under miljonprogrammet. Den principiella beräkningsgången går också att applicera på andra miljöaspekter såväl som för andra typer av byggnader och energiåtgärder. I rapporten görs beräkningarna för tre olika typer av fjärrvärmenät, samt för olika kontrasterande scenarier, bland annat kopplat till elsystemets utveckling. Sammantaget har projektet resulterat i en metod som länkar ihop tidsupplöst miljövärdering för fjärrvärme, fjärrkyla, och el med ett framåtblickande konsekvensperspektiv. Scenarioangreppssättet bidrar till att hantera in en del av de osäkerheter som är förknippade med framtidsstudier. Den utvecklade metoden kan i fortsatt tillämpning bidra till miljömässigt mer välgrundade beslut vid renovering och nybyggnation av fastigheter.
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| 35. |
- Hagberg, Martin, et al.
(författare)
-
Strategier för energieffektivisering ur ett fjärrvärmeperspektiv
- 2017
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Hur kan det integrerade fjärrvärme- och byggnadssystemet kostnadseffektivt möta mål om minskade CO2-utsläpp och fossilbränsleutfasning? Hur påverkas fjärrvärmeproduktionssystemet av olika teknikval för energieffektivisering i stadens byggnader? Det pågår just nu omfattande renoveringar av befintlig bebyggelse i Sverige. I samband med dessa renoveringar sker även energibesparande åtgärder av byggnadernas el- och värmebehov. Energieffektiviseringsåtgärder har effekter på såväl tillförsel- som användarsidan av energisystemet. Ett systemperspektiv är därför av stor vikt. Denna studies övergripande fokus är att med ett integrerat systemperspektiv på produktionssidan och användarsidan i en stads fjärrvärmesystem undersöka vägar för att nå framtida miljömål. Analysen använder ett fallstudie- och modellbaserat angreppssätt där Malmö stads fjärrvärmesystem och byggnadsbestånd ligger till grund. Arbetet inkluderar en kartläggning av byggnadsbestånd och fjärrvärmeproduktion i Malmö, identifiering av teknikåtgärder inklusive renoveringspaket för energieffektivisering, energisimuleringar på byggnadsnivå, utveckling av energisystemmodell för tillförsel- och användarled i fjärrvärmesystemet och, slutligen, modellkörningar och analys av resultat. Den utvecklade energisystemmodellen över Malmös energisystem, TIMES_Malmö, bygger på det internationellt etablerade modellgeneratorn TIMES. Modellen är en optimeringsmodell som beräknar den över tid kostnadsoptimala utvecklingen av det studerade systemet. Studien har en långsiktig tidshorisont och har 2050 som slutår för analysen. Resultaten visar bland annat att hur stadens miljömål definieras har en viktig betydelse för vilka teknikval och investeringar som är kostnadseffektiva i systemet. Miljömål där stadens påverkan på CO2-utsläpp utanför den egna stadens gränser inkluderas ger ett annat utfall än om fokus för miljömålen är på utfasning av fossila bränslen inom staden. Mål om ”fossilfrihet”, som fokuserar på minskning av fossila bränslen inom staden, leder i modellresultaten till en hög andel värmepumpar i fjärrvärmeproduktionen. Mål om ”CO2-neutralitet”, som tar hänsyn till effekter på elsystemet i det för staden omgivande systemet (marginalel), gynnar istället en högre andel kraftvärmeproduktion i fjärrvärmeproduktionen. Enklare teknikåtgärder för energieffektivisering i byggnadsbeståndet visar ofta samhällsekonomisk kostnadseffektivitet. Omfattande klimatskalsåtgärder ger en större energibesparing, men medför också en högre systemkostnad. Energieffektiviseringsåtgärder som minskar el- och värmeanvändning under årets kallare del då den totala efterfrågan är hög ger fördelar ur ett systemperspektiv. Åtgärder som främst minskar behovet av fjärrvärmens baslastproduktion ger i många fall begränsade fördelar ur ett systemperspektiv.
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| 36. |
- Hagberg, Niklas, 1977-, et al.
(författare)
-
The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
- 2018
-
Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 77:7, s. 1070-1077
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. This study aimed to clarify how the SLE-associated intronic STAT4 risk allele rs7574865[T] affects the function of immune cells in SLE.Methods Peripheral blood mononuclear cells (PBMCs) were isolated from 52 genotyped patients with SLE. Phosphorylation of STAT4 (pSTAT4) and STAT1 (pSTAT1) in response to interferon (IFN)-α, IFN-γ or interleukin (IL)-12, total levels of STAT4, STAT1 and T-bet, and frequency of IFN-γ+ cells on IL-12 stimulation were determined by flow cytometry in subsets of immune cells before and after preactivation of cells with phytohaemagglutinin (PHA) and IL-2. Cellular responses and phenotypes were correlated to STAT4 risk allele carriership. Janus kinase inhibitors (JAKi) selective for TYK2 (TYK2i) or JAK2 (JAK2i) were evaluated for inhibition of IL-12 or IFN-γ-induced activation of SLE PBMCs.Results In resting PBMCs, the STAT4 risk allele was neither associated with total levels of STAT4 or STAT1, nor cytokine-induced pSTAT4 or pSTAT1. Following PHA/IL-2 activation, CD8+ T cells from STAT4 risk allele carriers displayed increased levels of STAT4 resulting in increased pSTAT4 in response to IL-12 and IFN-α, and an augmented IL-12-induced IFN-γ production in CD8+ and CD4+ T cells. The TYK2i and the JAK2i efficiently blocked IL-12 and IFN-γ-induced activation of PBMCs from STAT4 risk patients, respectively.Conclusions T cells from patients with SLE carrying the STAT4 risk allele rs7574865[T] display an augmented response to IL-12 and IFN-α. This subset of patients may benefit from JAKi treatment.
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| 37. |
- Hagberg, Rasmus, et al.
(författare)
-
Using Program Analysis to Identify the Use of Vulnerable Functions
- 2021
-
Ingår i: 18th International Conference on Security and Cryptography, SECRYPT 2021. - : SCITEPRESS - Science and Technology Publications. - 9789897585241 ; , s. 520-530
-
Konferensbidrag (refereegranskat)abstract
- Open-Source Software (OSS) is increasingly used by software applications. It allows for code reuse, but also comes with the problem of potentially being affected by the vulnerabilities that are found in the OSS libraries. With large numbers of OSS components and a large number of published vulnerabilities, it becomes challenging to identify and analyze which OSS components need to be patched and updated. In addition to matching vulnerable libraries to those used in software products, it is also necessary to analyze if the vulnerable functionality is actually used by the software. This process is both time-consuming and error-prone. Automating this process presents several challenges, but has the potential to significantly decrease vulnerability exposure time. In this paper, we propose a modular framework for analyzing if software code is using the vulnerable part of a library, by analyzing and matching the call graphs of the software with changes resulting from security patches. Further, we provide an implementation of the framework targeting Java and the Maven dependency management system. This allows us to identify 20% of the dependencies in our sample projects as false positives. We also identify and discuss challenges and limitations in our approach
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| 38. |
- Hagberg, Tobias, et al.
(författare)
-
Efficacy of Transdiagnostic Cognitive-Behavioral Therapy for Assertiveness : A Randomized Controlled Trial
- 2023
-
Ingår i: SSRN Electronic Journal. - : Elsevier. - 1556-5068.
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Assertiveness training has been an essential component in cognitive-behavioral therapy (CBT), for example, in the treatment of social anxiety and in dialectical behavioral therapy. However, the assertiveness construct has garnered little attention in recent clinical research. The objective of this study was to investigate the efficacy of an eight-week transdiagnostic stand-alone internet-based CBT intervention specifically aimed at increasing levels of assertive behavior. Following inclusion, we randomized N = 210 participants into three groups: therapist-guided self-help, unguided self-help, and a wait-list control condition. After a one-year follow-up, we employed a linear mixed model to estimate the effects at both post-test and follow-up for the primary outcome measures of assertiveness, Adaptive and Aggressive Assertiveness Scales, the Rathus Assertiveness Schedule, and secondary outcome measures of anxiety, depression, and general well-being. We also assessed reliable clinical change. Compared to the wait list at the post-treatment, estimated between-group effect sizes on self-rated adaptive assertiveness were statistically equivalent for the two treatment groups both at the post and at the one-year follow-up time points, ranging from ES = 0.95 to 1.73, with reliable clinical recovery proportions from 19% to 36%. The increase in aggressive assertiveness ranged from ES = 0.62 to 0.90 compared to the wait-list condition at post. For social anxiety symptoms, the effects compared to the wait list at post-treatment ranged from ES = 0.67 to 0.93, with a reliable clinical recovery rate from 16% to 26%. For self-assessed well-being, the effects compared to the wait list at post ranged from ES = 0.70 to 1.05. No effects were observed for generalized anxiety, although within-group evidence was found for a medium effect on depression one year after treatment. Overall, the two treatment conditions produced similar effects. In general, participation increased healthy assertive expressions regardless of treatment condition, thereby reducing self-assessed social anxiety and, over time, possibly also depression. Participation also improved general well-being. The findings demonstrate that the assertiveness construct can be a suitable target for intervention, with reductions of both psychiatric symptoms and non-syndromal problems in daily life. The study was preregistered at ClinicalTrials.gov (NCT04240249).
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| 39. |
- Hagberg, Tobias, et al.
(författare)
-
Efficacy of transdiagnostic cognitive-behavioral therapy for assertiveness : A randomized controlled trial
- 2023
-
Ingår i: Internet Interventions. - : Elsevier. - 2214-7829. ; 32
-
Tidskriftsartikel (refereegranskat)abstract
- Assertiveness training has been an essential component in cognitive-behavioral therapy (CBT), for example, in the treatment of social anxiety and in dialectical behavioral therapy. However, the assertiveness construct has garnered little attention in recent clinical research. The objective of this study was to investigate the efficacy of an eight-week transdiagnostic stand-alone internet-based CBT intervention specifically aimed at increasing levels of assertive behavior. Following inclusion, we randomized N = 210 participants into three groups: therapist-guided self-help, unguided self-help, and a wait-list control condition. After a one-year follow-up, we employed a linear mixed model to estimate the effects at both post-test and follow-up for the primary outcome measures of assertiveness, Adaptive and Aggressive Assertiveness Scales, the Rathus Assertiveness Schedule, and secondary outcome measures of anxiety, depression, and general well-being. We also assessed reliable clinical change. Compared to the wait list at the post-treatment, estimated between-group effect sizes on self-rated adaptive assertiveness were statistically equivalent for the two treatment groups both at the post and at the one-year follow-up time points, ranging from ES = 0.95 to 1.73, with reliable clinical recovery proportions from 19 % to 36 %. The increase in aggressive assertiveness ranged from ES = 0.62 to 0.90 compared to the wait-list condition at post. For social anxiety symptoms, the effects compared to the wait list at post-treatment ranged from ES = 0.67 to 0.93, with a reliable clinical recovery rate from 16 % to 26 %. For self-assessed well-being, the effects compared to the wait list at post ranged from ES = 0.70 to 1.05. No effects were observed for generalized anxiety, although within-group evidence was found for a medium effect on depression one year after treatment. Overall, the two treatment conditions produced similar effects. In general, participation increased healthy assertive expressions regardless of treatment condition, all the while reducing self-assessed social anxiety and, over time, possibly also depression. Participation also improved general well-being. The findings demonstrate that the assertiveness construct can be a suitable target for intervention, with reductions of both psychiatric symptoms and non-syndromal problems in daily life. The study was preregistered at ClinicalTrials.gov (NCT04240249).
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| 40. |
- Hahlin, Maria, et al.
(författare)
-
Mapping the frontier electronic structures of triphenylamine based organic dyes at TiO2 interfaces
- 2011
-
Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 13:8, s. 3534-3546
-
Tidskriftsartikel (refereegranskat)abstract
- The frontier electronic structures of a series of organic dye molecules containing a triphenylamine moiety, a thiophene moiety and a cyanoacrylic acid moiety have been investigated by photoelectron spectroscopy (PES), X-ray absorption spectroscopy (XAS), X-ray emission spectroscopy (XES) and resonant photoelectron spectroscopy (RPES). The experimental results were compared to electronic structure calculations on the molecules, which are used to confirm and enrich the assignment of the spectra. The approach allows us to experimentally measure and interpret the basic valence energy level structure in the dye, including the highest occupied energy level and how it depends on the interaction between the different units. Based on N 1s X-ray absorption and emission spectra we also obtain insight into the structure of the excited states, the molecular orbital composition and dynamics. Together the results provide an experimentally determined energy level map useful in the design of these types of materials. Included are also results indicating femtosecond charge redistribution at the dye/TiO2 interface.
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| 41. |
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| 42. |
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| 43. |
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| 44. |
- Jiang, Zheshun, et al.
(författare)
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Circulating lung-cancer-related non-coding RNAs are associated with occupational exposure to hexavalent chromium : A cross-sectional study within the SafeChrom project
- 2024
-
Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 190
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Hexavalent chromium (Cr(Ⅵ)) is classified as a group 1 human carcinogen and increases the risk of lung cancer. Non-coding RNAs (ncRNAs) have key regulatory roles in lung cancer, but less is known about their relation to Cr(Ⅵ) exposure.OBJECTIVES: We aimed to 1) measure the expression of lung cancer-related circulating ncRNAs in exposed workers and controls; 2) assess associations between ncRNAs expression and Cr concentrations in red blood cells (RBC) and urine; and 3) evaluate correlations between the ncRNAs.METHODS: The study included 111 Cr(VI) exposed workers and 72 controls recruited from the SafeChrom project. Cr concentrations were measured in RBC (biomarker of long-term exposure) and urine (biomarker of short-term exposure) samples. Long ncRNA (lncRNA) and microRNA (miRNA) were extracted from plasma followed by deoxyribonuclease treatment, complementary DNA synthesis, and quantitative real-time polymerase chain reaction using target-specific assays for three lncRNAs (H19, MALAT1, NORAD), and four miRNAs (miR-142-3p, miR-15b-5p, miR-3940-5p, miR-451a).RESULTS: Expression levels of lncRNAs MALAT1 and NORAD, and all four miRNAs, were significantly lower in Cr(VI) exposed workers compared with controls, and correlated significantly with RBC-Cr concentrations (rS = -0.16 to -0.38). H19 was non-significantly increased in exposed workers but significantly correlated with miR-142-3p (rS = -0.33) and miR-15b-5p (rS = -0.30), and NORAD was significantly positively correlated with all four miRNAs (rS = 0.17 to 0.46). In multivariate regression models adjusting for confounders, expressions of lncRNAs MALAT1 and NORAD and all miRNAs were still significantly lower in the exposed group compared with controls, and the expression decreased with increasing RBC-Cr concentrations.CONCLUSIONS: Cr(VI) exposure was inversely and in a dose-response manner associated with the expression of circulating non-coding RNA, which suggests ncRNAs as potential biomarkers for Cr(VI)-induced toxicity. Correlations between miRNAs and lncRNAs suggest that they participate in the same lncRNA-miRNA-messenger RNA regulatory axes, which may play important roles in Cr(VI) carcinogenesis.
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| 45. |
- Jiang, Zheshun, et al.
(författare)
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Hexavalent chromium still a concern in Sweden : Evidence from a cross-sectional study within the SafeChrom project
- 2024
-
Ingår i: International journal of hygiene and environmental health. - : Elsevier. - 1438-4639 .- 1618-131X. ; 256
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesHexavalent chromium (Cr(VI)) is classified as a human carcinogen. Occupational Cr(VI) exposure can occur during different work processes, but the current exposure to Cr(VI) at Swedish workplaces is unknown.MethodsThis cross-sectional study (SafeChrom) recruited non-smoking men and women from 14 companies with potential Cr(VI) exposure (n = 113) and controls from 6 companies without Cr(VI) exposure (n = 72). Inhalable Cr(VI) was measured by personal air sampling (outside of respiratory protection) in exposed workers. Total Cr was measured in urine (pre- and post-shift, density-adjusted) and red blood cells (RBC) (reflecting Cr(VI)) in exposed workers and controls. The Bayesian tool Expostats was used to assess risk and evaluate occupational exposure limit (OEL) compliance.ResultsThe exposed workers performed processing of metal products, steel production, welding, plating, and various chemical processes. The geometric mean concentration of inhalable Cr(VI) in exposed workers was 0.15 μg/m3 (95% confidence interval: 0.11–0.21). Eight of the 113 exposed workers (7%) exceeded the Swedish OEL of 5 μg/m3, and the Bayesian analysis estimated the share of OEL exceedances up to 19.6% for stainless steel welders. Median post-shift urinary (0.60 μg/L, 5th-95th percentile 0.10–3.20) and RBC concentrations (0.73 μg/L, 0.51–2.33) of Cr were significantly higher in the exposed group compared with the controls (urinary 0.10 μg/L, 0.06–0.56 and RBC 0.53 μg/L, 0.42–0.72). Inhalable Cr(VI) correlated with urinary Cr (rS = 0.64) and RBC-Cr (rS = 0.53). Workers within steel production showed the highest concentrations of inhalable, urinary and RBC Cr. Workers with inferred non-acceptable local exhaustion ventilation showed significantly higher inhalable Cr(VI), urinary and RBC Cr concentrations compared with those with inferred acceptable ventilation. Furthermore, workers with inferred correct use of respiratory protection were exposed to significantly higher concentrations of Cr(VI) in air and had higher levels of Cr in urine and RBC than those assessed with incorrect or no use. Based on the Swedish job-exposure-matrix, approximately 17 900 workers were estimated to be occupationally exposed to Cr(VI) today.ConclusionsOur study demonstrates that some workers in Sweden are exposed to high levels of the non-threshold carcinogen Cr(VI). Employers and workers seem aware of Cr(VI) exposure, but more efficient exposure control strategies are required. National strategies aligned with the European strategies are needed in order to eliminate this cause of occupational cancer.
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| 46. |
- Jiang, Zheshun, et al.
(författare)
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P-205 THE SAFECHROM PROJECT - EVIDENCE FROM A CROSS-SECTIONAL STUDY SHOWS THAT HEXAVALENT CHROMIUM IS STILL A CONCERN IN SWEDEN
- 2024
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Ingår i: Occupational Medicine. - 0962-7480. ; 74:Suppl 1, s. 291-292
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Hexavalent chromium Cr(VI) is a human carcinogen, but the current exposure to Cr(VI) at Swedish workplaces is unknown.Recruitment of 113 workers with potential Cr(VI) exposure and 72 controls was combined with measurements of inhalable Cr(VI) (only exposed workers) and total Cr in urine and red blood cells (RBC), Bayesian analysis of occupational exposure limit (OEL) compliance was used, as well as the Swedish job-exposure-matrix.Exposed workers performed processing of metal products, steel production, welding, and plating. The geometric mean concentration of inhalable Cr(VI) in exposed workers was 0.15 μg/m3. Eight workers (7\ exceeded the Swedish OEL (5 μg/m3), and the share of OEL exceedances was estimated to be up to 19.6\ and RBC-Cr were significantly higher in exposed workers compared with controls. Workers with inferred non-acceptable local exhaustion ventilation showed significantly higher inhalable Cr(VI), urine- and RBC-Cr than those with acceptable ventilation. Workers with inferred correct use of respiratory protection had higher inhalable Cr(VI), and, paradoxically, higher urine- and RBC-Cr concentrations than workers with incorrect use. We estimate that ~17 900 Swedish workers are occupationally exposed to Cr(VI) today.Our study showed that although most air measurements were relatively low, 7\ and particularly stainless steel workers are at risk for exceeding the OEL. The existing protective measures implemented at workplaces are still inadequate and insufficient.Some workers in Sweden are exposed to high levels of the non-threshold carcinogen Cr(VI). National strategies aligned with European strategies are needed to eliminate occupational cancer.
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| 47. |
- Johnsson, Filip, 1960, et al.
(författare)
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Delrapport B2. Elektrifieringens betydelse för omställningen - till Klimaträttsutredningen M 2019:05
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna studie är dels att peka på betydelsen av elektrifieringen som åtgärd för att nå Sveriges klimatmål, dels att utreda vad detta kan komma att innebära för den framtida elanvändningen. Eftersom industrin och transportsektorn idag står för de största utsläppen av växthusgaser ligger fokus för denna studie på en analys av elektrifieringens roll i dessa sektorer. Vi kan konstatera att elektrifiering som klimatåtgärd inom industri och transport har rönt stor uppmärksamhet under de senaste åren. Det handlar bland annat om att järn- och stålindustrin, som står för de största industriella utsläppen av koldioxid i Sverige, har aviserat ett antal projekt och investeringar som, om de realiseras, helt kommer att ställa om denna bransch, kraftigt minska utsläppen av växthusgaser och väsentligt bidra till en ökad elförbrukning. Även andra industribranscher har aviserat ambitioner att ersätta fossil bränsleanvändning med el och vätgas. Men utvecklingen berör också transportsektorn där försäljningen av elfordon har tagit ordentlig fart och där flertalet prognoser pekar på att majoriteten av nybilsförsäljningen av lätta fordon kommer att utgöras av laddbara fordon innan 2030. Om denna utveckling fortgår och förstärks enligt de planer och ambitioner som finns så bedöms Sverige, genom elektrifieringen, ha goda förutsättningar att nå sitt nettonollutsläppsmål till 2045. Elektrifiering är inte den enda åtgärden som erfordras för den klimatpolitiska omställningen utan kommer att ackompanjeras av andra åtgärder som exempelvis ökad användning av biobränslen och effektiviseringar. Däremot pekar väldigt mycket på att elektrifiering kan bli den enskilt viktigaste åtgärden för att omställningen ska ske tillräckligt snabbt och i tillräcklig omfattning. Det finns dock ett antal viktiga omständigheter som kan utgöra hinder för en ökad elektrifiering och, därmed på sikt, äventyra de svenska klimatmålen. En omfattande elektrifiering av det slag som sannolikt krävs, och som analyseras i denna rapport, innebär en infrastrukturell kraftansträngning inte minst med avseende på utbyggnad av elnätsinfrastruktur och elproduktion. Ledtiderna för sådana satsningar kan av flera skäl bli mycket långdragna. Detta bidrar till ökade osäkerheter och riskerar leda till att projekt som syftar till minskade växthusgasutsläpp men som kräver ansenliga mängder el inte blir av. En genomgång av olika studier indikerar att den svenska elanvändningen kan komma att i princip fördubblas till 2050 givet att elektrifieringen blir omfattande inom industri och transporter. En omfattande elektrifiering är i grund och botten en önskvärd utveckling med tanke på klimatutmaningen. Men denna utveckling kommer också att fordra en bred samhällelig uppslutning för att bli lyckosam.
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| 48. |
- Juliusson, Gunnar, et al.
(författare)
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Acute myeloid leukemia in the real world : why population-based registries are needed
- 2012
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 119:17, s. 3890-3899
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Tidskriftsartikel (refereegranskat)abstract
- Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which are essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high coverage of the target population reduce the impact of selection on outcome and the subsequent problem with extrapolating data to nonstudied populations. Thus, data useful for clinical decision in situations not well covered by clinical studies can be provided. The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing more than 3300 acute myeloid leukemia (AML) patients diagnosed between 1997 and 2006 with a median follow-up of 6.2 years on (1) the role of intensive combination chemotherapy for older patients with AML, (2) the impact of allogeneic stem cell transplantation on survival of younger patients with AML, and (3) the continuing problem with early deaths in acute promyelocytic leukemia. We also present the first Web-based dynamic graph showing the complex interaction between age, performance status, the proportion of patients given intensive treatment, early death rate, complete remission rate, use of allogeneic transplants, and overall survival in AML (non-AML).
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| 49. |
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| 50. |
- Karlsson, K. Martin, et al.
(författare)
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Design and synthesis of novel organic chromophores for dye sensitized solar cells - 2
- 2008
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Ingår i: ACS National Meeting Book of Abstracts. - 9780841269859 ; , s. ORGN 493-
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Konferensbidrag (refereegranskat)abstract
- One of the main issues of today is the energy problem where the use of fossil fuels has lead to environmental changes. The development of environmentally friendly alternatives is therefore of great importance. The sun is the perfect energy source since it supplies the earth with much more energy than we currently need. The development of dye sensitized solar cells (DSSC's) is one possible low cost alternative to harvest the solar energy. Here we present a series of different organic dyes for DSSC's in our search for better understanding of the dye's influence on the solar cell's performance. The aim of this work has been to alter the linker between the donor and acceptor parts in the chromophore in order to investigate how this will influence light absorption and efficiency of the solar cell.
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