| 1. |
- Lindehammer, Sabina, et al.
(författare)
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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
- 2008
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Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
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| 2. |
- Andersson, Cecilia K, et al.
(författare)
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Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
- 2013
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 14:5, s. 341-349
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS: In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT. RESULTS: All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03). CONCLUSION: Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.
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| 3. |
- Axell, Erik, et al.
(författare)
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On the Optimal K-term Approximation of a Sparse Parameter Vector MMSE Estimate
- 2009
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Ingår i: Proceedings of the 2009 IEEE Workshop on Statistical Signal Processing (SSP'09). - : IEEE. - 9781424427093 ; , s. 245-248
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Konferensbidrag (refereegranskat)abstract
- This paper considers approximations of marginalization sums thatarise in Bayesian inference problems. Optimal approximations ofsuch marginalization sums, using a fixed number of terms, are analyzedfor a simple model. The model under study is motivated byrecent studies of linear regression problems with sparse parametervectors, and of the problem of discriminating signal-plus-noise samplesfrom noise-only samples. It is shown that for the model understudy, if only one term is retained in the marginalization sum, thenthis term should be the one with the largest a posteriori probability.By contrast, if more than one (but not all) terms are to be retained,then these should generally not be the ones corresponding tothe components with largest a posteriori probabilities.
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| 4. |
- Axell, Erik
(författare)
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Spectrum Sensing Algorithms Based on Second-Order Statistics
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cognitive radio is a new concept of reusing spectrum in an opportunistic manner. Cognitive radio is motivated by recent measurements of spectrum utilization, showing unused resources in frequency, time and space. Introducing cognitive radios in a primary network inevitably creates increased interference to the primary users. Secondary users must sense the spectrum and detect primary users' signals at very low SNR, to avoid causing too much interference.This dissertation studies this detection problem, known as spectrum sensing.The fundamental problem of spectrum sensing is to discriminate an observation that contains only noise from an observation that contains a very weak signal embedded in noise. In this work, detectors are derived that exploit known properties of the second-order moments of the signal. In particular, known structures of the signal covariance are exploited to circumvent the problem of unknown parameters, such as noise and signal powers or channel coefficients.The dissertation is comprised of six papers, all in different ways related to spectrum sensing based on second-order statistics. In the first paper, we considerspectrum sensing of orthogonal frequency-division multiplexed (OFDM) signals in an additive white Gaussian noise channel. For the case of completely known noise and signal powers, we set up a vector-matrix model for an OFDM signal with a cyclic prefix and derive the optimal Neyman-Pearson detector from first principles. For the case of completely unknown noise and signal powers, we derive a generalized likelihood ratio test (GLRT) based on empirical second-order statistics of the received data. The proposed GLRT detector exploits the non-stationary correlation structure of the OFDM signal and does not require any knowledge of the noise or signal powers.In the second paper, we create a unified framework for spectrum sensing of signals which have covariance matrices with known eigenvalue multiplicities. We derive the GLRT for this problem, with arbitrary eigenvalue multiplicities under both hypotheses. We also show a number of applications to spectrum sensing for cognitive radio.The general result of the second paper is used as a building block, in the third and fourth papers, for spectrum sensing of second-order cyclostationary signals received at multiple antennas and orthogonal space-time block coded (OSTBC) signals respectively. The proposed detector of the third paper exploits both the spatial and the temporal correlation of the received signal, from knowledge of the fundamental period of the cyclostationary signal and the eigenvalue multiplicities of the temporal covariance matrix.In the fourth paper, we consider spectrum sensing of signals encoded with an OSTBC. We show how knowledge of the eigenvalue multiplicities of the covariance matrix are inherent owing to the OSTBC, and propose an algorithm that exploits that knowledge for detection. We also derive theoretical bounds on the performance of the proposed detector. In addition, we show that the proposed detector is robust to a carrier frequency offset, and propose another detector that deals with timing synchronization using the detector for the synchronized case as a building block.A slightly different approach to covariance matrix estmation is taken in the fifth paper. We consider spectrum sensing of Gaussian signals with structured covariance matrices, and propose to estimate the unknown parameters of the covariance matrices using covariance matching estimation techniques (COMET). We also derive the optimal detector based on a Gaussian approximation of the sample covariance matrix, and show that this is closely connected to COMET.The last paper deals with the problem of discriminating samples that containonly noise from samples that contain a signal embedded in noise, when the variance of the noise is unknown. We derive the optimal soft decision detector using a Bayesian approach. The complexity of this optimal detector grows exponentially with the number of observations and as a remedy, we propose a number of approximations to it. The problem under study is a fundamental one andit has applications in signal denoising, anomaly detection, and spectrum sensing for cognitive radio.
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| 5. |
- Cirkic, Mirsad, et al.
(författare)
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Approximating the LLR Distribution for a Class of Soft-Output MIMO Detectors
- 2012
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Ingår i: IEEE Transactions on Signal Processing. - : Institute of Electrical and Electronics Engineers (IEEE). - 1053-587X .- 1941-0476. ; 60:12, s. 6421-6434
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Tidskriftsartikel (refereegranskat)abstract
- We present approximations of the LLR distribution for a class of fixed-complexity soft-output MIMO detectors, such as the optimal soft detector and the soft-output via partial marginalization detector. More specifically, in a MIMO AWGN setting, we approximate the LLR distribution conditioned on the transmitted signal and the channel matrix with a Gaussian mixture model (GMM). Our main results consist of an analytical expression of the GMM model (including the number of modes and their corresponding parameters) and a proof that, in the limit of high SNR, this LLR distribution converges in probability towards a unique Gaussian distribution.
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| 6. |
- Čirkić, Mirsad, 1984-, et al.
(författare)
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Gaussian Approximation of the LLR Distribution for the ML and Partial Marginalization MIMO detectors
- 2011
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Ingår i: Proceedings of the IEEE International Conference on Acoustics, Speech and SignalProcessing (ICASSP). - : IEEE conference proceedings. - 9781457705373 ; , s. 3232-3235
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Konferensbidrag (refereegranskat)abstract
- We derive a Gaussian approximation of the LLR distribution conditioned on the transmitted signal and the channel matrix for the soft-output via partial marginalization MIMO detector. This detector performs exact ML as a special case. Our main results consist of discussing the operational meaning of this approximation and a proof that, in the limit of high SNR, the LLR distribution of interest converges in probability towards a Gaussian distribution.
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| 7. |
- Kanatsuna, Norio, et al.
(författare)
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Doubly reactive INS-IGF2 autoantibodies in children with newly diagnosed autoimmune (type 1) diabetes.
- 2015
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Ingår i: Scandinavian Journal of Immunology. - : Wiley. - 1365-3083 .- 0300-9475. ; 82:4, s. 361-369
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Tidskriftsartikel (refereegranskat)abstract
- The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls. Patients (n=676), 0-18 years of age, diagnosed with type 1 diabetes in 1996-2005 and controls (n=363) were analyzed for specific INS-IGF2A after displacement with both cold insulin and INS-IGF2 to correct for non-specific binding and identify double reactive sera. GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA, and HLA-DQ genotypes were also determined. The median level of specific INS-IGF2A was higher in patients than controls (p<0.001). Irrespective of age at diagnosis, 19 % (126/676) of the patients had INS-IGF2A when the cut-off was the 95th percentile of the controls (p<0.001). The risk of INS-IGF2A was increased among HLA-DQ2/8 (OR=1.509; 95th CI 1.011, 2.252; p=0.045) but not in 2/2, 2/X, 8/8, 8/X or X/X (X is neither 2 nor 8) patients. The association with HLA-DQ2/8 suggests that this autoantigen may be presented on HLA-DQ trans, rather than cis heterodimers. Autoantibodies reactive with both insulin and INS-IGF2A at diagnosis support the notion that INS-IGF2 autoimmunity contributes to type 1 diabetes. This article is protected by copyright. All rights reserved.
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| 8. |
- Larsson, Niklas, et al.
(författare)
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Continuous flow hollow fiber liquid-phase microextraction and monitoring of NSAID pharmaceuticals in a sewage treatment plant effluent
- 2009
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Ingår i: Analytical Methods. - : Royal Society of Chemistry (RSC). - 1759-9660 .- 1759-9679. ; 1:1, s. 59-67
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Tidskriftsartikel (refereegranskat)abstract
- A method for simultaneous extraction and quantification Of four non-steroidal anti-inflammatory drugs (NSAIDs) based on continuous flow hollow fiber liquid-phase microextraction (CFHF-LPME) was developed. The effect of sample flow rate, acceptor flow rate, type of acceptor flow (continuous, semi-continuous or forward-backward), type of supported liquid membrane and sample volume was studied. The extraction of the final method was linear over an environmentally relevant concentration range and yielded high enrichment factors (720-940 times) in reagent water and (270-800 times) in sewage water for all analytes within 45 min. Repeatability was best (RSD 6-15%) during the first 30 min of extraction. The optimised method was used to monitor the occurrence and fate of the four NSAIDs in a Swedish sewage treatment plant (STP) effluent, which is discharged into a system of ponds before release into a river, during the period May-September 2008. All four analytes were detected at concentrations up to 0.92 mu g L-1 ketoprofen, 0.08 mu g L-1 naproxen, 0.43 mu g L-1 diclofenac and 0.25 mu g L-1 ibuprofen. A concentration drop during the summer was observed. For diclofenac and ketoprofen significant removal in the primary recipient pond system was observed. The presence of the studied pharmaceuticals in STP effluent together with concern about their environmental effects makes monitoring of their occurrence and knowledge of their environmental fate important. The proposed method provides a basis for automation of extraction towards on-site extraction using CFHF-LPME.
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| 9. |
- Lundgren, Markus, et al.
(författare)
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Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
- 2014
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X. ; 15:7, s. 494-501
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
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| 10. |
- Lundmark, Martin, et al.
(författare)
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The use of protective earth as a distributor of fields and radiation
- 2000
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Ingår i: Biological effects of EMFs. - Heraklio : Workshop on Biological Effects of Electromagnetic Fields. - 9608673305
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Konferensbidrag (refereegranskat)abstract
- Apart from being a safety arrangement, the protective earth, PE, is also defined as an equipotential plane which serves as a reference voltage for a circuit. Interest in the PE for EMC reasons is focused on an equipotential point. Still, most PE installation on site is carried out as a safety arrangement. In order to fulfill EMC standards regarding low emission, equipment is shielded and the shield is connected to the PE wire.The purpose of this paper is to show that electrical equipment distributes its electrical fields using the PE wire. Measurements have been taken on light fittings.
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