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Träfflista för sökning "WFRF:(Nordqvist P.) "

Sökning: WFRF:(Nordqvist P.)

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  • Laurell, CG, et al. (författare)
  • Computer-simulated phacoemulsification
  • 2004
  • Ingår i: Ophthalmology. - : Elsevier BV. - 0161-6420. ; 111:4, s. 693-698
  • Tidskriftsartikel (refereegranskat)
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  • Soderberg, P., et al. (författare)
  • Virtual cataract surgery : Clinical evaluation
  • 2003
  • Ingår i: Proceedings of SPIE, the International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 4951, s. 62-66
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • We have developed a simulator for phacoemulsification cataract extraction. In the current project, modules for clinical evaluation were developed. The system was structured into a processing computer and an administrator interface and a trainee interface. The simulation is defined by administrator adjustable parameters and trainee adjustable parameters. The parameters may be categorized as session characteristic parameters, patient characteristic parameters and trainee characteristic parameters. The simulation is measured in variables. Further an air bubble generator was created. We believe that simulator training in future will be required for becoming cataract surgeons.
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  • Davitt, C. J. H., et al. (författare)
  • Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines
  • 2019
  • Ingår i: Mucosal Immunology. - : Elsevier BV. - 1933-0219. ; 12, s. 1055-1064
  • Tidskriftsartikel (refereegranskat)abstract
    • Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3–4 million cases globally with 100,000–150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water and improved sanitation and hygiene, ideally in conjunction with oral vaccination. However, difficulties associated with the costs and logistics of these strategies have hampered their widespread implementation. Specific challenges pertaining to oral cholera vaccines (OCVs) include a lack of safe and effective adjuvants to further enhance gut immune responses, the complex and costly multicomponent vaccine manufacturing, limitations of conventional liquid formulation and the lack of an integrated delivery platform. Herein we describe the use of the orally active adjuvant α-Galactosylceramide (α-GalCer) to strongly enhance intestinal bacterium- and toxin-specific IgA responses to the OCV, Dukoral ® in C57BL/6 and BALB/c mice. We further demonstrate the mucosal immunogenicity of a novel multi-antigen, single-component whole-cell killed V. cholerae strain and the enhancement of its immunogenicity by adding α-GalCer. Finally, we report that combining these components and recombinant cholera toxin B subunit in the SmPill ® minisphere delivery system induced strong intestinal and systemic antigen-specific antibody responses. © 2019, The Author(s).
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