| 1. |
- Hedelind, Mikael, et al.
(författare)
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Factory-in-a-Box - Solutions for Availability and Mobility of Flexible Production Capacity
- 2007
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Ingår i: The Swedish Production Symposium,2007.
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Konferensbidrag (refereegranskat)abstract
- The objective of this paper is to present examples of how to realize a flexible and reconfigurable production system. An ongoing research project in Sweden called Factory-in-a-Box will be presented which is one research initiative within this area. The purpose of the Factory-in-a-Box project is to develop solutions for mobile production capacity on demand. Three key features have been identified as enablers for these kinds of production capabilities: mobility, flexibility, and speed. The concept consists of standardized modules that can be installed in e.g. containers and easily transported by trucks, rail vehicles, and boats. The modules can easily be combined into complete production systems and reconfigured for new products and/or scaled to handle new volumes. The goal of the Factory-in-a-Box project is to build fully operative production modules that are developed in close cooperation between different academic and industrial partners. This paper will present the results from these demonstrators giving examples of the usability of the Factory-in-a-Box concept in industry.
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| 2. |
- Anglert, Mats, et al.
(författare)
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Att lägga ut diskursen i landskapet
- 2006
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Ingår i: Centraliteter. Människor, strategier och landskap.. - 917209429X ; , s. 13-50
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- An introductory chapter in a book about centrality in the Late Iron Age and the Early Middle Ages. The chapter focusses on concept formation regarding centrality, hierarchy and heterarchy, the landscape, complexity, aristocratization and urbanization.
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| 3. |
- Augustsson, Anna, et al.
(författare)
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Failure of generic risk assessment model framework to predict groundwater pollution risk at hundreds of metal contaminated sites : Implications for research needs
- 2020
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 185, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Soil pollution constitutes one of the major threats to public health, where spreading to groundwater is one of several critical aspects. In most internationally adopted frameworks for routine risk assessments of contaminated land, generic models and soil guideline values are cornerstones. In order to protect the groundwater at contaminated sites, a common practice worldwide today is to depart from health risk-based limit concentrations for groundwater, and use generic soil-to-groundwater spreading models to back-calculate corresponding equilibrium levels (concentration limits) in soil, which must not be exceeded at the site. This study presents an extensive survey of how actual soil and groundwater concentrations, compiled for all high-priority contaminated sites in Sweden, relate to the national model for risk management of contaminated sites, with focus on As, Cu, Pb and Zn. Results show that soil metal concentrations, as well as total amounts, constitute a poor basis for assessing groundwater contamination status. The evaluated model was essentially incapable of predicting groundwater contamination (i.e. concentrations above limit values) based on soil data, and erred on the "unsafe side" in a significant number of cases, with modelled correlations not being conservative enough. Further, the risk of groundwater contamination was almost entirely independent of industry type. In essence, since neither soil contaminant loads nor industry type is conclusive, there is a need for a supportive framework for assessing metal spreading to groundwater accounting for site-specific, geochemical conditions.
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| 4. |
- Bergström, Göran, 1964, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 5. |
- Bergström, Göran, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 6. |
- Ekblom, Örjan, 1971-, et al.
(författare)
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Concurrent and predictive validity of physical activity measurement items commonly used in clinical settings- data from SCAPIS pilot study
- 2015
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Ingår i: Bmc Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Background: As the understanding of how different aspects of the physical activity (PA) pattern relate to health and disease, proper assessment is increasingly important. In clinical care, self-reports are the most commonly used assessment technique. However, systematic comparisons between questions regarding concurrent or criterion validity are rare, as are measures of predictive validity. The aim of the study was to examine the concurrent (using accelerometry as reference) and predictive validity (for metabolic syndrome) of five PA questions. Methods: A sample of 948 middle-aged Swedish men and women reported their PA patterns via five different questions and wore an accelerometer (Actigraph GT3X) for a minimum of 4 days. Concurrent validity was assessed as correlations and ROC-analyses. Predictive validity was assessed using logistic regression, controlling for potential confounders. Results: Concurrent validity was low-to-moderate (r < 0.35 and ROC AUC < 0.7) with large misclassifications regarding time spent sitting/sedentary and in moderate-to vigorous PA. The predictive validity of the questions was good, and one question (PHAS) showed an 80 % decreased odds-ratio of having metabolic syndrome, after taking potential confounders into consideration. Discussion: In this mixed sample of adults, both concurrent and predictive validity vaired between items and between measures of the physical activity pattern. The PHAS and WALK items are proposed for assessment of adherence to PA recommendations. Conclusion: Assessing PA patterns using self-report measures results in methodological problems when trying to predict individual risk for the metabolic syndrome, as the concurrent validity generally was low. However, several of the investigated questions may be useful for assessing risk at a group level, showing better predictive validity.
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| 7. |
- Engstrand, Per, 1955-, et al.
(författare)
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Improved refining energy efficiency in thermo-mechanical pulping by means of collimated wood chipping – from solid mechanics to full scale evaluation
- 2016
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Ingår i: PaperWeek Canada 2016 Conference <em>February 1 to 5, 2016, Montreal</em>.
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Konferensbidrag (refereegranskat)abstract
- The wood chipping process was never optimized with regard to high yield pulping processes as thermomechanical pulping (TMP) and chemithermomechanical pulping (CTMP). It is generally believed that wood chips for pulping should be produced in such a way that the degree of damage is minimized and that the chip dimensional distribution should be as narrow as possible. Since the TMP and CTMP processes were developed in the 60-ies and 70-ies, compression screw as well as roll nip equipment have been developed to pretreat wood chips as a way to reduce refining energy consumption to given fiber and pulp properties and also in order to improve impregnation. The general conclusions are that a combination of shear and compression in the tangential or radial direction of the wood initiates cracks that later in the refiner will enhance and optimize fiber separation and also fiber property development. The idea with the collimated chipping technology is to utilize the wood chipper as a tool, combining cutting of wood logs to wood chips with a pretreatment of the chips by creating cracks that would enhance fiber separation, fiber surface development as well as chip-impregnation. In this case the compression is performed in the wood fiber direction, in which direction wood actually is weakest when it comes to compression induced cracking. The maximization of the amount of cracks in wood-chips is performed by optimizing the knife angle (or spout angle) in the chipper, to what we call collimated chipping (according to a patent owned by CCT AB). This presentation describes a theoretical background and two demonstration scale studies performed by SCA Forest Products at their Ortviken mill. One conclusion drawn, based on two-month test period with three weeks of collimated chipping, was that specific refining energy reduction was around 100 kWh/adt of the 1400 kWh/adt used in primary stage double disc refining. Most probably the potential is higher if the whole system is optimized. Tests were performed at constant production rate and energy was reduced by reducing power to constant freeness, leading to similar tensile and light scattering levels. The deliberately increased forces created in the wood chipper by means of an optimized (increased) edge angle caused more problems with knife holder equipment than normally, as well as increased vibrations. These problems will have to be solved for future long-term implementation of the technique.
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| 8. |
- Landegren, Ulf, et al.
(författare)
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Molecular tools for a molecular medicine : analyzing genes, transcripts and proteins using padlock and proximity probes
- 2004
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Ingår i: Journal of Molecular Recognition. - : Wiley. - 0952-3499 .- 1099-1352. ; 17:3, s. 194-7
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Tidskriftsartikel (refereegranskat)abstract
- Procedures and reagents are needed to specifically detect all the macromolecules that are being identified in the course of genome projects. We discuss how this challenge may be met using a set of ligation-based reagents termed padlock probes and proximity ligation probes. These probes include elements with affinity for specific nucleic acid and protein molecules, respectively, along with unique identifier DNA sequence elements that encode the identity of the recognized target molecules. The information content of DNA strands that form in the detection reactions are recorded after amplification, allowing the recognized target molecules to be identified. The procedures permit highly specific solution-phase or localized analyses of large sets of target molecules as required in future molecular analyses.
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| 9. |
- Landegren, Ulf, et al.
(författare)
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Padlock and proximity probes for in situ and array-based analyses : tools for the post genomic era
- 2003
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Ingår i: Comparative and functional genomics. - : Hindawi Limited. - 1531-6912 .- 1532-6268. ; 4:5, s. 525-30
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Tidskriftsartikel (refereegranskat)abstract
- Highly specific high-throughput assays will be required to take full advantage of the accumulating information about the macromolecular composition of cells and tissues, in order to characterize biological systems in health and disease. We discuss the general problem of detection specificity and present the approach our group has taken, involving the reformatting of analogue biological information to digital reporter segments of genetic information via a series of DNA ligation assays. The assays enable extensive, coordinated analyses of the numbers and locations of genes, transcripts and protein.
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| 10. |
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