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| 2. |
- Albrektsson, Tomas, 1945, et al.
(författare)
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Histologic investigations on 33 retrieved Nobelpharma implants.
- 1993
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Ingår i: Clinical materials. - 0267-6605. ; 12:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- Thirty Nobelpharma implants were retrieved from 17 patients despite a remaining clinical stability, after between 1 and 16 years of clinical function. The reasons for implant removal were bone resorption in combination with soft tissue disorders, psychological causes, implant fracture and post mortem cases. When measured at the cortical passage, there was an average of 84.9% direct bone-to-implant contact and 81.8% average surface bone area in individual threads as evaluated in a computerized morphometric system at the light microscopic level.
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| 3. |
- Andersson, P., et al.
(författare)
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Factors Influencing Resonance Frequency Analysis (RFA) Measurements and 5-Year Survival of Neoss Dental Implants
- 2019
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Ingår i: International Journal of Dentistry. - : Hindawi Limited. - 1687-8728 .- 1687-8736. ; - 2019
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Tidskriftsartikel (refereegranskat)abstract
- - Background. Diagnostic instruments based on resonance frequency analysis (RFA) can be utilised to assess dental implant stability during treatment and follow-up. Aim. The aim of the present study was to investigate the influence of patient- and implant-related factors on implant stability and the 5-year implant survival. In addition, the influence of stability (ISQ value) at placement and abutment connection on implant survival was evaluated. Materials and Methods. RFA measurements from a total of 334 consecutive patients with 745 dental implants (Neoss Ltd., Harrogate, UK) were retrospectively analysed after at least 5 years in function. Statistics were used to evaluate the influence of the different variables on implant stability and implant survival. Odds ratio calculations were performed to compare the risk for implant failure using 60, 65, 70, and 75 ISQ as threshold levels at placement and loading. Results. A total of 20 implant failures in 14 patients were noted during the 5 years of follow-up, giving an overall cumulative survival rate (CSR) of 97.3% at the implant level and 95.8% at the patient level. Gender, jaw, position, bone quality, and implant diameter had an influence on implant stability at placement. Jaw, bone quality, and implant diameter had an influence on stability after 3-4 months of healing. More failures were observed in full than in partial rehabilitations. Age, gender, jaw, position, bone quantity, bone quality, implant diameter, and implant length had no influence on implant survival. Implants with ISQ values below the threshold levels showed lower survival rates compared to implants with values above these levels. Conclusions. The present study showed a significantly higher risk for implant failure, showing an ISQ value below 70 and 75 at placement or after 3-4 months of healing. The results indicate that RFA measurements can be used to identify implants with increased risk for failure. © 2019 Peter Andersson et al.
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| 5. |
- Buranawat, B, et al.
(författare)
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Evaluation of a Beta-Calcium Metaphosphate Bone Graft Containing Bone Morphogenetic Protein- 7 (OP-1) in Rabbit Maxillary Defects.
- 2014
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Ingår i: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 85:2, s. 298-307
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Tidskriftsartikel (refereegranskat)abstract
- Background: Calcium phosphate based materials have been widely used as bone substitutes and more recently are being exploited together with growth factors as bone tissue engineering scaffolds regulating cell behavior. The aim of the study was to evaluate the in vitro and in vivo response to a newly developed calcium metaphosphate bone graft, with and without bone stimulating growth factor. Materials and methods: Porous scaffolds of β calcium metaphosphate (CMP) were developed and extensively tested in vitro. Subsequently, CMP grafts with osteogenic protein 1 (OP-1) (test) and, without (control) were implanted into experimental rabbit maxillary bone defects. Animals were sacrificed 2, 4, and 8 weeks and samples examined with micro-computed tomography (µCT) and processed for histomorphometric analysis. Results: At 8 weeks the scaffolds containing OP-1 induced greater bone formation (P=0.018) than CMP alone, based on histomorphometric evaluation, % Bone area [Test 57.1±5.6 and Control 49.4±7.7] and micro-CT analysis, % Bone volume density (BV/TV) [Test 63.46±5.61 and Control 51.20±6.71]. Thus, this data indicated that both test and control CMP grafts showed a good degree of bone formation. Furthermore, the CMP materials showed signs of resorption from 4 weeks and no graft materials were observed at 8 weeks. Conclusion: In vitro the OP-1 loaded graft demonstrated a release profile and bioactivity over a 28 day period. In vivo testing confirmed enhanced bone formation of the OP-1 loaded graft after 8 weeks of healing.
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| 6. |
- Grossi-Oliveira, G.A., et al.
(författare)
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Early Osseointegration Events on Neoss® ProActive and Bimodal Implants: A Comparison of Different Surfaces in an Animal Model
- 2015
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 17:6, s. 1060-1072
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Tidskriftsartikel (refereegranskat)abstract
- © 2015 Wiley Periodicals, Inc. Background: Cell interactions, adherence, and osseointegration at the bone-implant interface can be directly influenced by the surface properties of the titanium implant. Purpose: To characterize osseointegration of Neoss® implants with conventional (control group) and hydrophilic (test group) surface treatments. Materials and Methods: Six Labrador dogs received Neoss implants with conventional and hydrophilic surfaces. The bone-implant interfaces were evaluated 1 and 4 weeks after implantation, and osseointegration was evaluated using histological, histomorphometric, fluorescence, and resonance frequency analyses. The surfaces were also subjected to topographic and hydrophilicity analyses. Results: The topographic analyses revealed increased surface roughness in the test group compared with the control group (surface area roughness 0.42 and 0.78μm, respectively, for control and test group surfaces; p≤.05). The wettability values were higher in the test group (contact angles 67.2° and 27.2° for the control and test group surfaces, respectively; p≤.05). Implants in the test group also exhibited better stability, more bone-implant contact, and increased bone area compared with implants in the control group. Conclusion: Neoss implants in the test group improved bone formation in the early stages of osseointegration compared with implants in the control group.
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| 7. |
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| 8. |
- Hallman, M, et al.
(författare)
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Histologic analysis of clinical biopsies taken 6 months and 3 years after maxillary sinus floor augmentation with 80% bovine hydroxyapatite and 20% autogenous bone mixed with fibrin glue.
- 2001
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Ingår i: Clinical Implant Dentistry and Related Research. - 1523-0899 .- 1708-8208. ; 3:2, s. 87-96
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Bovine hydroxyapatite (Bio-Oss, Geistlich Pharmaceutical, Wollhausen, Switzerland) has been suggested to be used in maxillary sinus floor augmentation procedures prior to or in conjunction with implant placement. However, the long-term histologic fate of this material is not well understood. PURPOSE: The aim with this study was to histologically evaluate the tissue response in patients to a mixture of bovine hydroxyapatite (BH), autogenous bone, and fibrin glue 6 months and 3 years after a maxillary sinus floor augmentation procedure. MATERIALS AND METHOD: Biopsies were taken from a group of 20 consecutive patients 6 months (n = 16) and 3 years (n = 12) after maxillary sinus floor augmentation with a mixture of BH (80%), autogenous bone (20%), and fibrin glue and prepared for histologic analysis. RESULTS: Light microscopy and morphometry from biopsies taken after 6 months showed various amounts of mineralized bone tissue. The specimen area was occupied by 54.1 +/- 12.6% nonmineralized tissue, followed by 21.2 +/- 24.5% lamellar bone, 14.5 +/- 10.3% BH particles, and 10.2 +/- 13.4% woven bone. The nonmineralized tissue seen in bone-forming areas consisted of a loose connective tissue, rich with vessels and cells. There were no signs of resorption of the BH particles. The lamellar bone appeared to have originated from the recipient site and was seldom in contact with the BH particles. After 3 years, the nonmineralized tissue area had decreased to 36.0 +/- 19.0% (p < .05) and consisted mainly of bone marrow tissue. The surface area of lamellar bone had increased to 50.7 +/- 22.8% (p < .05), and there was almost no immature bone. The mean specimen area occupied by BH particles, was 12.4 +/- 8.7% and had not changed from 6 months (not significant). Moreover, the sizes of the particles were similar after 6 months and 3 years. The degree of BH particle-bone contact had increased from 28.8% +/- 19.9% after 6 months to 54.5 +/- 28.8% after 3 years (p < .05). CONCLUSION: Histology of specimens from maxillary sinuses augmented with 80% BH particles, 20% autogenous bone, and fibrin glue showed a positive bone tissue response after 6 months and 3 years after augmentation of the maxillary sinus floor prior to implant placement in a group fo 20 patients. The bone surrounding and in contact with the BH particles after 6 months was mainly immature woven bone, which with time was replaced by mature lamellar bone filling the interparticle space as observed in the 3-year specimens. Moreover, bone-integrated BH particles seem to be resistant to resorption. The results indicate that the procedure may be considered when only small amounts of intraoral autogenous bone graft are available.
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| 9. |
- Lundgren, Stefan, et al.
(författare)
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Spontaneous bone formation in the maxillary sinus after removal of a cyst: coincidence or consequence?
- 2003
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Ingår i: Clinical Implant Dentistry and Related Research. ; 5:2, s. 78-81
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Maxillary sinus floor-augmentation techniques are frequently used to increase the bone volume in the posterior edentulous maxilla to enable placement and integration of titanium implants. PURPOSE: The purpose of this report is to document an unexpected healing pattern after maxillary sinus surgery and to discuss the implications for future bone-augmentation techniques. MATERIALS AND METHODS: In a patient referred for sinus augmentation, an intrasinus mucosal cyst was removed 3 months prior to the planned augmentation procedure. A replaceable bone window was prepared in the lateral aspect of the sinus wall. The cyst was removed, the ruptured mucosa was sutured, and the bone window was replaced, resulting in a secluded space in the sinus. RESULTS: After 3 months of healing, the space between the replaced bony window and the lifted sinus membrane was filled with newly formed bone. The surgical technique was repeated in a second patient and resulted in a similar bone reformation pattern. CONCLUSION: Surgical trauma and the creation of a secluded space between the bone surfaces and the sinus mucosa result in spontaneous bone formation in the maxillary sinus. The surgical approach described may be used to achieve bone reformation to enable placement of dental implants without the addition of any grafting material.
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