SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1531 8257 "

Sökning: L773:1531 8257

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
41.
  •  
42.
  •  
43.
  •  
44.
  • Fasano, A., et al. (författare)
  • Gaps, Controversies, and Proposed Roadmap for Research in Normal Pressure Hydrocephalus
  • 2020
  • Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 35:11, s. 1945-1954
  • Tidskriftsartikel (refereegranskat)abstract
    • Idiopathic normal pressure hydrocephalus is considered common but remains underinvestigated. There are no uniformly accepted diagnostic criteria and therapeutic guidelines. We summarize the accumulated evidence regarding the definition, pathophysiology, diagnosis, and treatment of idiopathic normal pressure hydrocephalus, highlighting the many gaps and controversies, including diagnostic challenges, the frequent association with neurodegeneration and vascular disease, and the many unknowns regarding patient selection and outcome predictors. A roadmap to fill these gaps and solve the controversies around this condition is also proposed. More evidence is required with respect to diagnostic criteria, the value of ancillary testing, prospective population-based studies and novel trial designs. Furthermore, a need exists to develop new advanced options in shunt technology. (c) 2020 International Parkinson and Movement Disorder Society
  •  
45.
  • Fazio, P, et al. (författare)
  • Corrigendum
  • 2020
  • Ingår i: Movement disorders : official journal of the Movement Disorder Society. - : Wiley. - 1531-8257. ; 35:12, s. 2363-2364
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
46.
  •  
47.
  •  
48.
  •  
49.
  •  
50.
  • Fernandez, Hubert H., et al. (författare)
  • Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson's Disease: Final 12-Month, Open-Label Results
  • 2015
  • Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 30:4, s. 500-509
  • Tidskriftsartikel (refereegranskat)abstract
    • Motor complications in Parkinson's disease (PD) are associated with long-term oral levodopa treatment and linked to pulsatile dopaminergic stimulation. l-dopa-carbidopa intestinal gel (LCIG) is delivered continuously by percutaneous endoscopic gastrojejunostomy tube (PEG-J), which reduces l-dopa-plasma-level fluctuations and can translate to reduced motor complications. We present final results of the largest international, prospective, 54-week, open-label LCIG study. PD patients with severe motor fluctuations (>3 h/day off time) despite optimized therapy received LCIG monotherapy. Additional PD medications were allowed >28 days post-LCIG initiation. Safety was the primary endpoint measured through adverse events (AEs), device complications, and number of completers. Secondary endpoints included diary-assessed off time, on time with/without troublesome dyskinesia, UPDRS, and health-related quality-of-life (HRQoL) outcomes. Of 354 enrolled patients, 324 (91.5%) received PEG-J and 272 (76.8%) completed the study. Most AEs were mild/moderate and transient; complication of device insertion (34.9%) was the most common. Twenty-seven (7.6%) patients withdrew because of AEs. Serious AEs occurred in 105 (32.4%), most commonly complication of device insertion (6.5%). Mean daily off time decreased by 4.4 h/65.6% (P<0.001). On time without troublesome dyskinesia increased by 4.8 h/62.9% (P<0.001); on time with troublesome dyskinesia decreased by 0.4 h/22.5% (P=0.023). Improvements persisted from week 4 through study completion. UPDRS and HRQoL outcomes were also improved throughout. In the advanced PD population, LCIG's safety profile consisted primarily of AEs associated with the device/procedure, l-dopa/carbidopa, and advanced PD. LCIG was generally well tolerated and demonstrated clinically significant improvements in motor function, daily activities, and HRQoL sustained over 54 weeks. (c) 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (204)
konferensbidrag (8)
forskningsöversikt (4)
Typ av innehåll
refereegranskat (190)
övrigt vetenskapligt/konstnärligt (26)
Författare/redaktör
Aarsland, D (24)
Hariz, Marwan (18)
Svenningsson, P (17)
Zetterberg, Henrik, ... (14)
Mollenhauer, B. (10)
Hariz, Marwan I. (9)
visa fler...
Limousin, Patricia (9)
Weintraub, D (8)
Nyholm, Dag (8)
Nilsson, Christer (8)
Hansson, Oskar (8)
Zrinzo, Ludvic (8)
Puschmann, Andreas (8)
Constantinescu, Radu ... (7)
Blomstedt, Patric (7)
Forsgren, Lars (7)
Foltynie, Thomas (7)
Brockmann, K. (7)
Lang, AE (7)
Gagliardi, M. (6)
Kim, YJ (6)
Carr, J. (6)
Wirdefeldt, K (6)
Hagell, Peter (6)
Belin, AC (6)
Gasser, T. (6)
Odin, Per (6)
Stefanis, L (6)
Kruger, R (6)
Holmberg, Björn (6)
Markaki, I. (6)
Hariz, Gun-Marie (6)
Brice, A (6)
Ferreira, JJ (6)
Corvol, JC (6)
Mellick, GD (6)
Tolosa, E (6)
Lesage, S (6)
Valente, EM (6)
Zimprich, A (6)
Petrucci, S (6)
Brighina, L (6)
Litvan, I (5)
Bergquist, Filip, 19 ... (5)
Ran, C. (5)
Lang, Anthony E. (5)
Tisch, Stephen (5)
Guedes, LC (5)
Wirdefeldt, Karin (5)
Bloem, BR (5)
visa färre...
Lärosäte
Karolinska Institutet (94)
Lunds universitet (51)
Umeå universitet (38)
Göteborgs universitet (35)
Uppsala universitet (12)
Linköpings universitet (8)
visa fler...
Örebro universitet (7)
Högskolan Kristianstad (3)
Kungliga Tekniska Högskolan (3)
Stockholms universitet (1)
Chalmers tekniska högskola (1)
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (216)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (131)
Teknik (2)
Naturvetenskap (1)
Lantbruksvetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy