SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0012 186X "

Sökning: L773:0012 186X

  • Resultat 11-20 av 1954
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  •  
12.
  •  
13.
  • Abels, Mia, et al. (författare)
  • CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
  • 2016
  • Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 59:9, s. 1928-1937
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims/hypothesis Insufficient insulin release and hyperglucagonaemia are culprits in type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART, encoded by Cartpt) affects islet hormone secretion and beta cell survival in vitro in rats, and Cart(-/-) mice have diminished insulin secretion. We aimed to test if CART is differentially regulated in human type 2 diabetic islets and if CART affects insulin and glucagon secretion in vitro in humans and in vivo in mice. Methods CART expression was assessed in human type 2 diabetic and non-diabetic control pancreases and rodent models of diabetes. Insulin and glucagon secretion was examined in isolated islets and in vivo in mice. Ca2+ oscillation patterns and exocytosis were studied in mouse islets. Results We report an important role of CART in human islet function and glucose homeostasis in mice. CART was found to be expressed in human alpha and beta cells and in a subpopulation of mouse beta cells. Notably, CART expression was several fold higher in islets of type 2 diabetic humans and rodents. CART increased insulin secretion in vivo in mice and in human and mouse islets. Furthermore, CART increased beta cell exocytosis, altered the glucose-induced Ca2+ signalling pattern in mouse islets from fast to slow oscillations and improved synchronisation of the oscillations between different islet regions. Finally, CART reduced glucagon secretion in human and mouse islets, as well as in vivo in mice via diminished alpha cell exocytosis. Conclusions/interpretation We conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin secretion and reduce glucagon secretion, CART-based agents could be a therapeutic modality in type 2 diabetes.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  • Adiels, Martin, 1976, et al. (författare)
  • Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance
  • 2007
  • Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 50:11, s. 2356-2365
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS/HYPOTHESIS: Overproduction of VLDL(1) seems to be the central pathophysiological feature of the dyslipidaemia associated with type 2 diabetes. We explored the relationship between liver fat and suppression of VLDL(1) production by insulin in participants with a broad range of liver fat content. METHODS: A multicompartmental model was used to determine the kinetic parameters of apolipoprotein B and TG in VLDL(1) and VLDL(2) after a bolus of [(2)H(3)]leucine and [(2)H(5)]glycerol during a hyperinsulinaemic-euglycaemic clamp in 20 male participants: eight with type 2 diabetes and 12 control volunteers. The participants were divided into two groups with low or high liver fat. All participants with diabetes were in the high liver-fat group. RESULTS: The results showed a rapid drop in VLDL(1)-apolipoprotein B and -triacylglycerol secretion in participants with low liver fat during the insulin infusion. In contrast, participants with high liver fat showed no significant change in VLDL(1) secretion. The VLDL(1) suppression following insulin infusion correlated with the suppression of NEFA, and the ability of insulin to suppress the plasma NEFA was impaired in participants with high liver fat. A novel finding was an inverse response between VLDL(1) and VLDL(2) secretion in participants with low liver fat: VLDL(1) secretion decreased acutely after insulin infusion whereas VLDL(2) secretion increased. CONCLUSIONS/INTERPRETATION: Insulin downregulates VLDL(1) secretion and increases VLDL(2) secretion in participants with low liver fat but fails to suppress VLDL(1) secretion in participants with high liver fat, resulting in overproduction of VLDL(1). Thus, liver fat is associated with lack of VLDL(1) suppression in response to insulin.
  •  
18.
  • Adiels, Martin, 1976, et al. (författare)
  • Overproduction of large VLDL particles is driven by increased liver fat content in man
  • 2006
  • Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 49:4, s. 755-65
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS/HYPOTHESIS: We determined whether hepatic fat content and plasma adiponectin concentration regulate VLDL(1) production. METHODS: A multicompartment model was used to simultaneously determine the kinetic parameters of triglycerides (TGs) and apolipoprotein B (ApoB) in VLDL(1) and VLDL(2) after a bolus of [(2)H(3)]leucine and [(2)H(5)]glycerol in ten men with type 2 diabetes and in 18 non-diabetic men. Liver fat content was determined by proton spectroscopy and intra-abdominal fat content by MRI. RESULTS: Univariate regression analysis showed that liver fat content, intra-abdominal fat volume, plasma glucose, insulin and HOMA-IR (homeostasis model assessment of insulin resistance) correlated with VLDL(1) TG and ApoB production. However, only liver fat and plasma glucose were significant in multiple regression models, emphasising the critical role of substrate fluxes and lipid availability in the liver as the driving force for overproduction of VLDL(1) in subjects with type 2 diabetes. Despite negative correlations with fasting TG levels, liver fat content, and VLDL(1) TG and ApoB pool sizes, adiponectin was not linked to VLDL(1) TG or ApoB production and thus was not a predictor of VLDL(1) production. However, adiponectin correlated negatively with the removal rates of VLDL(1) TG and ApoB. CONCLUSIONS/INTERPRETATION: We propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver. Elevated plasma glucose can further increase hepatic fat content through multiple pathways, resulting in overproduction of VLDL(1) particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes.
  •  
19.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-20 av 1954
Typ av publikation
tidskriftsartikel (998)
konferensbidrag (929)
forskningsöversikt (26)
annan publikation (1)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (998)
refereegranskat (956)
Författare/redaktör
Groop, Leif (97)
Zierath, JR (80)
Brismar, K (79)
OSTENSON, CG (78)
Efendic, S (77)
Berggren, PO (74)
visa fler...
Norhammar, A. (61)
Arner, P (60)
Grill, V (56)
WAHREN, J (53)
Bolinder, J (48)
Krook, A (45)
Rydén, L. (43)
Carlsson, S (42)
Nystrom, T (39)
Sjoholm, A (38)
Lernmark, Åke (35)
Ahren, Bo (34)
Eriksson, Jan W. (34)
Lyssenko, Valeriya (33)
Leibiger, IB (33)
Tuomi, T. (32)
Mulder, Hindrik (31)
Mandrup-Poulsen, T (31)
Groop, L. (30)
Orho-Melander, Marju (29)
Gudbjornsdottir, S. (28)
Franks, Paul W. (27)
Rolandsson, Olov (26)
Bjorklund, A (25)
Korsgren, Olle (24)
LERNMARK, A (24)
Zethelius, Björn (24)
Hilding, A (24)
Ling, Charlotte (24)
Hamsten, A (24)
Wallberg-Henriksson, ... (24)
Carlsson, Per-Ola (24)
Ludvigsson, Johnny (23)
JOHANSSON, BL (23)
Renström, Erik (22)
Smith, Ulf, 1943 (22)
Catrina, SB (22)
SUNDKVIST, G (21)
Almgren, Peter (21)
Ekberg, K (21)
Tuomi, Tiinamaija (20)
Ahlqvist, Emma (20)
Sanjeevi, CB (20)
Dahlquist, G (20)
visa färre...
Lärosäte
Karolinska Institutet (1155)
Lunds universitet (430)
Uppsala universitet (273)
Umeå universitet (130)
Göteborgs universitet (91)
Linköpings universitet (79)
visa fler...
Örebro universitet (33)
Kungliga Tekniska Högskolan (18)
Chalmers tekniska högskola (15)
Högskolan Dalarna (9)
Sveriges Lantbruksuniversitet (7)
Stockholms universitet (6)
Malmö universitet (5)
Högskolan i Halmstad (4)
Jönköping University (3)
Gymnastik- och idrottshögskolan (3)
Linnéuniversitetet (3)
Högskolan i Gävle (2)
Mälardalens universitet (2)
Södertörns högskola (2)
Luleå tekniska universitet (1)
Handelshögskolan i Stockholm (1)
Sophiahemmet Högskola (1)
Röda Korsets Högskola (1)
visa färre...
Språk
Engelska (1949)
Odefinierat språk (5)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (775)
Naturvetenskap (5)
Samhällsvetenskap (3)
Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy