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Sökning: L773:0959 4965

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  • Boisvert, Isabelle, et al. (författare)
  • Long-term monaural auditory deprivation and bilateral cochlear implants
  • 2012
  • Ingår i: NeuroReport. - : Lippincott, Williams and Wilkins. - 0959-4965 .- 1473-558X. ; 23:3, s. 195-199
  • Tidskriftsartikel (refereegranskat)abstract
    • Long-term binaural auditory deprivation is associated with poorer speech recognition outcomes after cochlear implantation, even for postlingual hearing loss. It is, however, unknown to what extent the outcomes of implantation are related to the peripheral changes occurring monaurally or to changes at a higher level in the auditory system related to binaural deafness. This retrospective study aimed to unravel peripheral and central contributions to cochlear implantation outcomes by comparing outcomes obtained in individual ears for adults with long-term monaural auditory deprivation (i.e. unilateral use of hearing aid) who received bilateral cochlear implants. Results showed that similar outcomes can be obtained with the implant placed in the auditory-deprived or in the aided ear. This suggests that the peripheral changes related to monaural auditory deprivation have little effect on outcomes of cochlear implantation. NeuroReport 23: 195-199
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  • Bomberg, Eric M, et al. (författare)
  • Central ghrelin induces feeding driven by energy needs not by reward
  • 2007
  • Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 18:6, s. 591-595
  • Tidskriftsartikel (refereegranskat)abstract
    • Centrally administered ghrelin, the endogenous agonist of the growth hormone secretegogue receptor, powerfully stimulates food intake. Although the orexigenic action of this peptide has been well established, it remains unclear whether ghrelin-induced hyperphagia is driven by energy needs or by reward. In our study ghrelin was injected into the lateral cerebral ventricle or the hypothalamic paraventricular nucleus of rats given a choice between a palatable yet calorie-dilute sucrose solution and a calorically dense chow. As a result of intraventricular and hypothalamic paraventricular ghrelin injections, animals increased intake of chow but not sucrose. When the sucrose solution was offered as the only source of calories, rats treated with ghrelin infused in the ventricle and site-specifically increased sucrose consumption. These results suggest that the primary effect of ghrelin is to stimulate food intake to satisfy energy needs.
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