| 51. |
- Brackman, Damien, et al.
(författare)
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Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis
- 2011
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Ingår i: Nephrology Dialysis Transplantation. - : Oxford University Press (OUP). - 1460-2385 .- 0931-0509. ; 26:10, s. 3399-3403
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Tidskriftsartikel (refereegranskat)abstract
- A 4-year-old boy presented with proteinuria and developed progressive renal failure over 6 years. In the patient's family, five individuals were affected with atypical haemolytic uraemic syndrome (aHUS) but not the patient. Renal biopsies (n = 3) showed glomerular basement membrane thickening with double contours, endothelial swelling and deposits of C3 and C1q. Electron microscopy revealed mesangial and subendothelial electron-dense deposits. Complement mutations in membrane cofactor protein (Y155D) and C3 (R713W and G1094R) were detected in all affected family members. The patient also had transient autoantibodies to factor H. The findings suggest that aHUS and glomerulopathy resembling membranoproliferative glomerulonephritis may have a common molecular background.
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| 52. |
- Braide, Magnus, 1955, et al.
(författare)
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Citrate supplementation of PD fluid: effects on net ultrafiltration and clearance of small solutes in single dwells
- 2009
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Ingår i: Nephrol Dial Transplant. - 1460-2385. ; 24:1, s. 286-92
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Inflammatory reactions affect the general performance as well as the technique survival of peritoneal dialysis (PD). Anti-inflammatory additives like heparin and sodium citrate have shown favourable results in these respects. The present study is the first to evaluate citrate-supplemented PD fluids (PDFs) in humans. METHODS: Crossover design was used to evaluate sodium citrate and heparin-supplemented Gambrosol Trio (2.5% glucose) in 28 stable outpatients from the PD unit. Comparisons were made between single dwells of each fluid. Citrate supplementation at 5 mM/L was compared with standard PDF, and citrate supplementation at 10 mM/L was compared with low-molecular-weight heparin (4500 units of tinzaparin) supplementation and standard PDF. The initial osmolarity of the fluids was equalized by adding sodium chloride. RESULTS: Citrate supplementation at 5 mM/L significantly increased net ultrafiltration, measured as drained volume gain, by 126 mL. Creatinine and phosphate clearance, but not glucose clearance, was significantly improved by supplementation with citrate or heparin. Heparin supplementation created an insignificant trend towards an increased ultrafiltration (P = 0.08). No negative side effects were reported for any of the treatments; however, citrate supplementation led to a small calcium loss by the drained PD fluid (0.4 mmol) and a transient fall in the plasma concentration (0.04 mM/L) of free calcium ions at 5 mM/L citrate. Effects on plasma bicarbonate concentration were insignificant. CONCLUSIONS: Citrate supplementation of PD fluid improved ultrafiltration and clearance of small solutes with only minor effects on calcium turnover. The mechanism is unknown and, according to the results, not related to complement inhibition.
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| 53. |
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| 54. |
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| 55. |
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| 56. |
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| 57. |
- Bruchfeld, A, et al.
(författare)
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Interferon and ribavirin therapy in dialysis patients with chronic hepatitis C
- 2001
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 0931-0509. ; 16:8, s. 1729-1729
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 58. |
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| 59. |
- Bruchfeld, A, et al.
(författare)
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Pegylated interferon and ribavirin in haemodialysis patients
- 2006
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 0931-0509. ; 21:5, s. 1444-1445
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 60. |
- Bruchfeld, A, et al.
(författare)
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Rituximab for minimal change disease in adults: long-term follow-up
- 2014
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Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 29:4, s. 851-856
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Tidskriftsartikel (refereegranskat)
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