SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1532 1827 "

Sökning: L773:1532 1827

  • Resultat 51-60 av 723
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
51.
  •  
52.
  •  
53.
  •  
54.
  •  
55.
  •  
56.
  •  
57.
  •  
58.
  •  
59.
  • Bamia, C., et al. (författare)
  • Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
  • 2015
  • Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 112:7, s. 1273-1282
  • Tidskriftsartikel (refereegranskat)abstract
    • Background:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1) increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d(-1) increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.
  •  
60.
  • Barnes, N. L. P., et al. (författare)
  • Cyclooxygenase-2 inhibition : effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer
  • 2007
  • Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 96:4, s. 575-582
  • Tidskriftsartikel (refereegranskat)abstract
    • Cyclooxygenase-2 (COX-2) is associated with poor-prognosis breast cancer. We used a nude mouse xenograft model to determine the effects of COX-2 inhibition in breast cancer. Oestrogen receptor (ER)-positive MCF7/HER2-18 and ER-negative MDAMB231 breast cancer cell lines were injected into nude mice and allowed to form tumours. Mice then received either chow containing Celecoxib (a COX-2 inhibitor) or control and tumour growth measured. Tumour proliferation, apoptosis, COX-2, lymphangiogenesis and angiogenesis were assessed by immunohistochemistry (IHC), Western blotting or Q-PCR. Celecoxib inhibited median tumour growth in MCF7/HER2-18 (58.7%, P=0.029) and MDAMB231 (46.3%, P=0.0002) cell lines compared to control. Cyclooxygenase-2 expression decreased following Celecoxib treatment (MCF7/HER2-18 median control 65.3% vs treated 22.5%, P=0.0001). Celecoxib increased apoptosis in MCF7/HER2-18 tumours (TUNEL 0.52% control vs 0.73% treated, P=0.0004) via inactivation of AKT (median pAKT(ser473) 57.3% control vs 35.5% treated, P=0.0001--confirmed at Western blotting). Q-PCR demonstrated decreased podoplanin RNA (lymphangiogenesis marker) in the MCF7/HER2-18 - median 2.9 copies treated vs 66.6 control (P=0.05) and MDAMB231-treated groups--median 160.7 copies vs 0.05 control copies (P=0.015), confirmed at IHC. Cyclooxygenase-2 is associated with high levels of activated AKT(ser473) and lymphangiogenesis in breast cancer. Cyclooxygenase-2 inhibition decreases tumour growth, and may potentially decrease recurrence, by inactivating AKT and decreasing lymphangiogenesis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 51-60 av 723
Typ av publikation
tidskriftsartikel (716)
forskningsöversikt (7)
Typ av innehåll
refereegranskat (702)
övrigt vetenskapligt/konstnärligt (21)
Författare/redaktör
Hemminki, K (28)
Wolk, A (23)
Weiderpass, E (20)
Glimelius, Bengt (20)
Hall, P (20)
Trichopoulos, D (20)
visa fler...
Lagergren, J (18)
Overvad, K (16)
Kaaks, R. (16)
Khaw, K. T. (16)
Boeing, H. (15)
Tumino, R. (15)
Riboli, E. (15)
Ekbom, A (15)
Adami, HO (15)
Olsson, Håkan (14)
Ye, W. (14)
Bueno-de-Mesquita, H ... (14)
Czene, K (14)
Lindblom, A (13)
Tjonneland, A (12)
Pukkala, E (12)
Holmberg, Lars (12)
Boffetta, P (12)
Peterlongo, P (11)
Andersson, S (11)
Palli, D (11)
Ardanaz, E. (10)
Nyren, O (10)
Dillner, J (9)
Kogner, P (9)
Lagiou, P (9)
Dillner, Joakim (9)
Chang-Claude, J (9)
Chenevix-Trench, G (9)
Jirström, Karin (9)
Ferrari, P. (8)
Li, X. (8)
Aaltonen, LA (8)
Benitez, J. (8)
Clavel-Chapelon, F. (8)
Key, T. J. (8)
Ahlman, Håkan, 1947 (8)
Adolfsson, J. (8)
Glimelius, B (8)
Steineck, G (8)
Feychting, M (8)
Hamann, U (8)
Radice, P (8)
Lubinski, J (8)
visa färre...
Lärosäte
Karolinska Institutet (497)
Lunds universitet (150)
Uppsala universitet (135)
Umeå universitet (79)
Göteborgs universitet (55)
Linköpings universitet (49)
visa fler...
Örebro universitet (18)
Chalmers tekniska högskola (5)
Kungliga Tekniska Högskolan (4)
Stockholms universitet (4)
Mälardalens universitet (4)
Jönköping University (2)
Malmö universitet (2)
Mittuniversitetet (1)
Södertörns högskola (1)
visa färre...
Språk
Engelska (723)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (306)
Naturvetenskap (4)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy