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  • Result 51-60 of 542
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53.
  • Bonjer, H Jaap, et al. (author)
  • A randomized trial of laparoscopic versus open surgery for rectal cancer.
  • 2015
  • In: The New England journal of medicine. - 1533-4406. ; 372:14, s. 1324-32
  • Journal article (peer-reviewed)abstract
    • Laparoscopic resection of colorectal cancer is widely used. However, robust evidence to conclude that laparoscopic surgery and open surgery have similar outcomes in rectal cancer is lacking. A trial was designed to compare 3-year rates of cancer recurrence in the pelvic or perineal area (locoregional recurrence) and survival after laparoscopic and open resection of rectal cancer.
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54.
  • Bosch, Jackie, et al. (author)
  • n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.
  • 2012
  • In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 367:4, s. 309-18
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown.METHODS: In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovascular events and had impaired fasting glucose, impaired glucose tolerance, or diabetes to receive a 1-g capsule containing at least 900 mg (90% or more) of ethyl esters of n-3 fatty acids or placebo daily and to receive either insulin glargine or standard care. The primary outcome was death from cardiovascular causes. The results of the comparison between n-3 fatty acids and placebo are reported here.RESULTS: During a median follow up of 6.2 years, the incidence of the primary outcome was not significantly decreased among patients receiving n-3 fatty acids, as compared with those receiving placebo (574 patients [9.1%] vs. 581 patients [9.3%]; hazard ratio, 0.98; 95% confidence interval [CI], 0.87 to 1.10; P=0.72). The use of n-3 fatty acids also had no significant effect on the rates of major vascular events (1034 patients [16.5%] vs. 1017 patients [16.3%]; hazard ratio, 1.01; 95% CI, 0.93 to 1.10; P=0.81), death from any cause (951 [15.1%] vs. 964 [15.4%]; hazard ratio, 0.98; 95% CI, 0.89 to 1.07; P=0.63), or death from arrhythmia (288 [4.6%] vs. 259 [4.1%]; hazard ratio, 1.10; 95% CI, 0.93 to 1.30; P=0.26). Triglyceride levels were reduced by 14.5 mg per deciliter (0.16 mmol per liter) more among patients receiving n-3 fatty acids than among those receiving placebo (P<0.001), without a significant effect on other lipids. Adverse effects were similar in the two groups.CONCLUSIONS: Daily supplementation with 1 g of n-3 fatty acids did not reduce the rate of cardiovascular events in patients at high risk for cardiovascular events. (Funded by Sanofi; ORIGIN ClinicalTrials.gov number, NCT00069784.).
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55.
  • Bostrom, P, et al. (author)
  • New cells in old hearts
  • 2013
  • In: The New England journal of medicine. - 1533-4406. ; 368:14, s. 1358-1360
  • Journal article (peer-reviewed)
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  • Result 51-60 of 542
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Diaz, Rafael (12)
Diaz, R. (10)
Wallentin, Lars (10)
Yusuf, Salim (10)
Harrington, Robert A (9)
Adami, HO (9)
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Rosengren, Annika, 1 ... (9)
Parkhomenko, Alexand ... (9)
Fröbert, Ole, 1964- (8)
Wallentin, Lars, 194 ... (8)
Collins, R (7)
Swedberg, Karl, 1944 (7)
Holmberg, Lars (7)
Held, Claes, 1956- (7)
Leiter, Lawrence A (7)
Bill-Axelson, Anna (7)
Lewis, Basil S. (7)
Bergh, J (6)
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Moreau, P (5)
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Toni, D. (5)
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James, Stefan, 1964- (5)
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Lopes, Renato D. (5)
Witt, N (5)
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Zhu, Jun (5)
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