161201. |
- Sigal, R, et al.
(författare)
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EURORAD, the EAR database project
- 1999
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Ingår i: EUROPEAN RADIOLOGY. - 0938-7994. ; 9:2, s. 371-378
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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161202. |
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161203. |
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161204. |
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161205. |
- Sigfridsson, Jonathan, et al.
(författare)
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Prospective data-driven respiratory gating of [Ga-68]Ga-DOTATOC PET/CT
- 2021
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Ingår i: EJNMMI Research. - : Springer Nature. - 2191-219X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of this prospective study was to evaluate a data-driven gating software's performance, in terms of identifying the respiratory signal, comparing [Ga-68]Ga-DOTATOC and [F-18]FDG examinations. In addition, for the [Ga-68]Ga-DOTATOC examinations, tracer uptake quantitation and liver lesion detectability were assessed.Methods: Twenty-four patients with confirmed or suspected neuroendocrine tumours underwent whole-body [Ga-68]Ga-DOTATOC PET/CT examinations. Prospective DDG was applied on all bed positions and respiratory motion correction was triggered automatically when the detected respiratory signal exceeded a certain threshold (R value >= 15), at which point the scan time for that bed position was doubled. These bed positions were reconstructed with quiescent period gating (QPG), retaining 50% of the total coincidences. A respiratory signal evaluation regarding the software's efficacy in detecting respiratory motion for [Ga-68]Ga-DOTATOC was conducted and compared to [F-18]FDG data. Measurements of SUVmax, SUVmean, and tumour volume were performed on [Ga-68]Ga-DOTATOC PET and compared between gated and non-gated images.Results: The threshold of R >= 15 was exceeded and gating triggered on mean 2.1 bed positions per examination for [Ga-68]Ga-DOTATOC as compared to 1.4 for [F-18]FDG. In total, 34 tumours were evaluated in a quantitative analysis. An increase of 25.3% and 28.1%, respectively, for SUVmax (P < 0.0001) and SUVmean (P < 0.0001), and decrease of 21.1% in tumour volume (P < 0.0001) was found when DDG was applied.Conclusions: High respiratory signal was exclusively detected in bed positions where respiratory motion was expected, indicating reliable performance of the DDG software on [Ga-68]Ga-DOTATOC PET/CT. DDG yielded significantly higher SUVmax and SUVmean values and smaller tumour volumes, as compared to non-gated images.
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161206. |
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161207. |
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161208. |
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161209. |
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161210. |
- Sighel, Denise, et al.
(författare)
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Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
- 2021
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 35:4
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Tidskriftsartikel (refereegranskat)abstract
- Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting mitochondrial translation and report the results of high-content screening with putative blockers of mitochondrial ribosomes. We identify the bacterial antibiotic quinupristin/dalfopristin (Q/D) as an effective suppressor of GSC growth. Q/D also decreases the clonogenicity of GSCs in vitro, consequently dysregulating the cell cycle and inducing apoptosis. Cryoelectron microscopy (cryo-EM) reveals that Q/D binds to the large mitoribosomal subunit, inhibiting mitochondrial protein synthesis and functionally dysregulating OXPHOS complexes. These data suggest that targeting mitochondrial translation could be explored to therapeutically suppress GSC growth in GBM and that Q/D could potentially be repurposed for cancer treatment.
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