SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:ki "

Sökning: LAR1:ki

  • Resultat 162631-162640 av 201633
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
162631.
  • Sjolander, KB, et al. (författare)
  • Evaluation of serological methods for diagnosis of Puumala hantavirus infection (nephropathia epidemica)
  • 1997
  • Ingår i: Journal of clinical microbiology. - : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 35:12, s. 3264-3268
  • Tidskriftsartikel (refereegranskat)abstract
    • Nephropathia epidemica (NE), Puumala (PUU) virus infection, is a febrile disease which is commonly associated with acute renal impairment. To differentiate NE from other acute febrile illnesses, a rapid and reliable serological diagnosis is important, and a number of different protocols have recently been introduced. In the present report we describe a comparative evaluation of six PUU virus immunoglobulin M (IgM) and seven IgG enzyme-linked immunosorbent assay (ELISA) protocols based on native, Escherichia coli-expressed, or baculovirus-expressed nucleocapsid protein (N). Neutralization and immunofluorescence assays were included for comparison. Equally high sensitivities and specificities were obtained with three mu-capture-based IgM ELISAs using native, baculovirus-expressed, and E. coli-expressed N antigens, respectively, and by an ELISA based on purified E. coli-expressed full-length N adsorbed to solid phase. The assays based on truncated amino-terminal N proteins, including a commercially available PUU virus IgM ELISA, all showed lower sensitivities. For detection of PUU virus-specific IgG, ELISAs based on monoclonal antibody-captured native or baculovirus-expressed N antigens showed optimal sensitivities and specificities, while the assays based on E. coli-expressed N did not detect all PUU virus IgG-positive serum samples. A commercially available PUU virus IgG ELISA based on E. coli-expressed amino-terminal N showed a significantly lower sensitivity than those of all other IgG assays.
  •  
162632.
  •  
162633.
  •  
162634.
  • Sjolin, H, et al. (författare)
  • DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection
  • 2006
  • Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 177:5, s. 2908-2916
  • Tidskriftsartikel (refereegranskat)abstract
    • DAP12 is an ITAM-containing adaptor molecule conveying activating properties to surface receptors on many cell types. We show here that DAP12 paradoxically down-modulates plasmacytoid dendritic cell (pDC) cytokine production in vivo during murine CMV (MCMV) infection. Higher levels of IFN-αβ and IL-12 were detected upon MCMV infection or CpG treatment in DAP12-deficient (DAP12°) mice as compared with wild-type (WT) mice. This resulted from altered homeostasis and enhanced responsiveness of pDCs in DAP12° animals. Increased numbers of pDCs were observed in the periphery of both naive and MCMV-infected DAP12° mice. A higher proportion of pDCs was activated in infected DAP12° mice, as demonstrated by intracellular staining using an optimized protocol for simultaneous detection of IFN-α and IFN-β. The homeostasis of WT and DAP12° pDCs did not differ in mixed bone marrow chimeric mice. In addition, a similar efficiency of pDC differentiation was observed in vitro in Fms-like tyrosine kinase receptor 3 ligand cultures of WT and DAP12° bone marrow cells. This suggests that DAP12 signaling effects on pDC homeostasis are indirect. In contrast, in response to CpG, DAP12-mediated effects on both IL-12 and IFN-αβ production were intrinsic to the pDCs. However, in response to MCMV, only IL-12 but not IFN-αβ production was affected by pDC-intrinsic DAP12 signaling. Thus, DAP12 signaling in pDCs can mediate different regulatory effects on their functions, depending on the mechanisms of pDC activation. The potential implications of the regulation of pDC functions by DAP12 for promoting health over disease are discussed.
  •  
162635.
  •  
162636.
  • Sjolin, H, et al. (författare)
  • Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection
  • 2002
  • Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 195:7, s. 825-834
  • Tidskriftsartikel (refereegranskat)abstract
    • Natural killer (NK) cells are major contributors to early defense against infections. Their effector functions are controlled by a balance between activating and inhibiting signals. To date, however, the involvement of NK cell activating receptors and signaling pathways in the defense against pathogens has not been extensively investigated. In mice, several NK cell activating receptors are coexpressed with and function through the immunoreceptor tyrosine-based activation motif (ITAM)-bearing molecule KARAP/DAP12. Here, we have analyzed the role of KARAP/DAP12 in the early antiviral response to murine cytomegalovirus (MCMV). In KARAP/DAP12 mutant mice bearing a nonfunctional ITAM, we found a considerable increase in viral titers in the spleen (30–40-fold) and in the liver (2–5-fold). These effects were attributed to NK cells. The formation of hepatic inflammatory foci appeared similar in wild-type and mutant mice, but the latter more frequently developed severe hepatitis with large areas of focal necrosis. Moreover, the percentage of hepatic NK cells producing interferon γ was reduced by 56 ± 22% in the absence of a functional KARAP/DAP12. This is the first study that shows a crucial role for a particular activating signaling pathway, in this case the one induced through KARAP/DAP12, in the NK cell–mediated resistance to an infection. Our results are discussed in relation to recent reports demonstrating that innate resistance to MCMV requires the presence of NK cells expressing the KARAP/DAP12-associated receptor Ly49H.
  •  
162637.
  •  
162638.
  •  
162639.
  •  
162640.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 162631-162640 av 201633
Typ av publikation
tidskriftsartikel (163003)
konferensbidrag (26955)
doktorsavhandling (9211)
forskningsöversikt (2120)
licentiatavhandling (252)
bokkapitel (43)
visa fler...
annan publikation (34)
konstnärligt arbete (4)
rapport (4)
recension (4)
proceedings (redaktörskap) (1)
visa färre...
Typ av innehåll
refereegranskat (150856)
övrigt vetenskapligt/konstnärligt (50741)
populärvet., debatt m.m. (30)
Författare/redaktör
aut (1543)
Winblad, B (925)
Halldin, C (909)
KLARESKOG, L (832)
Lindholm, B (792)
Stenvinkel, P (772)
visa fler...
Olsson, T (756)
Gustafsson, JA (694)
Ljungman, P (687)
Ringden, O (686)
Hillert, J (675)
Fuxe, K (657)
Lichtenstein, P. (654)
Carrero, JJ (638)
Aarsland, D (599)
Hemminki, K (588)
Alfredsson, L (582)
Eriksson, M (561)
Pedersen, NL (547)
Wolk, Alicja (545)
Farde, L (537)
Askling, J (533)
Larsson, Henrik, 197 ... (527)
Gissler, M (523)
Hall, P (520)
Bulik, CM (505)
Weiderpass, E (497)
Piehl, F (480)
Kere, J (479)
Rydén, L. (477)
Melen, E (476)
Bachert, C (466)
Lundberg, IE (459)
Lund, LH (458)
Hokfelt, T (453)
Hamsten, A (451)
Adami, HO (445)
Bergh, J (440)
Lagergren, J (433)
Andersson, Gerhard (428)
Ingelman-Sundberg, M (427)
Lichtenstein, Paul (417)
Ekbom, A (416)
Czene, K (409)
Arner, P (407)
Cnattingius, S (404)
Larsson, Susanna C. (403)
Larsson, C (402)
Ludvigsson, Jonas F. ... (402)
Svenningsson, P (399)
visa färre...
Lärosäte
Karolinska Institutet (201633)
Uppsala universitet (17899)
Lunds universitet (7936)
Göteborgs universitet (7512)
Linköpings universitet (6655)
Stockholms universitet (6271)
visa fler...
Umeå universitet (6249)
Örebro universitet (5070)
Kungliga Tekniska Högskolan (3410)
Högskolan Dalarna (1274)
Mälardalens universitet (873)
Jönköping University (832)
Gymnastik- och idrottshögskolan (781)
Linnéuniversitetet (720)
Sophiahemmet Högskola (682)
Mittuniversitetet (677)
Marie Cederschiöld högskola (609)
Röda Korsets Högskola (592)
Sveriges Lantbruksuniversitet (552)
Chalmers tekniska högskola (538)
Södertörns högskola (536)
Högskolan i Gävle (455)
Malmö universitet (410)
Högskolan i Skövde (336)
Högskolan i Borås (300)
Luleå tekniska universitet (281)
Karlstads universitet (281)
Högskolan i Halmstad (237)
Handelshögskolan i Stockholm (150)
RISE (144)
Högskolan Kristianstad (98)
VTI - Statens väg- och transportforskningsinstitut (72)
Högskolan Väst (69)
Blekinge Tekniska Högskola (63)
Försvarshögskolan (16)
Naturhistoriska riksmuseet (15)
Kungl. Musikhögskolan (9)
IVL Svenska Miljöinstitutet (5)
Konstfack (4)
Enskilda Högskolan Stockholm (1)
visa färre...
Språk
Engelska (201479)
Svenska (146)
Odefinierat språk (6)
Tyska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (40228)
Naturvetenskap (4337)
Samhällsvetenskap (4329)
Teknik (948)
Lantbruksvetenskap (248)
Humaniora (201)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy