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Sökning: WFRF:(Bellani M.)

  • Resultat 11-14 av 14
  • Föregående 1[2]
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  • Laffey, John G, et al. (författare)
  • Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome : the LUNG SAFE study
  • 2016
  • Ingår i: Intensive Care Medicine. - 0342-4642 .- 1432-1238. ; 42:12, s. 1865-1876
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents. A pre-specified secondary aim was to examine the factors associated with outcome. Analyses were restricted to patients (93.1 %) fulfilling ARDS criteria on day 1-2 who received invasive mechanical ventilation.RESULTS: 2377 patients were included in the analysis. Potentially modifiable factors associated with increased hospital mortality in multivariable analyses include lower PEEP, higher peak inspiratory, plateau, and driving pressures, and increased respiratory rate. The impact of tidal volume on outcome was unclear. Having fewer ICU beds was also associated with higher hospital mortality. Non-modifiable factors associated with worsened outcome from ARDS included older age, active neoplasm, hematologic neoplasm, and chronic liver failure. Severity of illness indices including lower pH, lower PaO2/FiO2 ratio, and higher non-pulmonary SOFA score were associated with poorer outcome. Of the 578 (24.3 %) patients with a limitation of life-sustaining therapies or measures decision, 498 (86.0 %) died in hospital. Factors associated with increased likelihood of limitation of life-sustaining therapies or measures decision included older age, immunosuppression, neoplasia, lower pH and increased non-pulmonary SOFA scores.CONCLUSIONS: Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS.TRIAL REGISTRATION: ClinicalTrials.gov NCT02010073.
  • Tsikritzis, Dimitris, et al. (författare)
  • A two-fold engineering approach based on Bi2Te3 flakes towards efficient and stable inverted perovskite solar cells
  • 2020
  • Ingår i: Materials Advances. - 2633-5409. ; 1:3, s. 450-462
  • Tidskriftsartikel (refereegranskat)abstract
    • Perovskite solar cells (PSCs) are currently the leading thin-film photovoltaic technology owing to their high power conversion efficiency (PCE), as well as their low-cost and facile manufacturing process. Two-dimensional (2D) materials have been reported to improve both the PCE and the stability of PSCs when incorporated across the device's layered configuration. Hereby, a two-fold engineering approach is implemented in inverted PSCs by using ultra-thin Bi2Te3 flakes, i.e.: (1) to dope the electron transport layer (ETL) and (2) to form a protective interlayer above the ETL. Thorough steady-state and time-resolved transport analyses reveal that our first engineering approach improves the electron extraction rate and thus the overall PCE (+6.6% vs. reference cells), as a result of the favourable energy level alignment between the perovskite, the ETL and the cathode. Moreover, the Bi2Te3 interlayer, through the second engineering approach, facilitates further the electron transport and in addition protects the underlying structure against chemical instability effects, leading to enhanced device performance and stability. By combining the two engineering approaches, our optimised PSCs reach a PCE up to 19.46% (+15.2% vs. reference cells) and retain more than 80% of their initial PCE, after the burn-in phase, over 1100 h under continous 1 sun illumination. These performances are among the highest reported in the literature for inverted PSCs.
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  • Resultat 11-14 av 14
  • Föregående 1[2]

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