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Sökning: WFRF:(Dehghan A)

  • Resultat 101-107 av 107
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  • Huffman, Jennifer E., et al. (författare)
  • Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
  • 2015
  • Ingår i: PLOS ONE. - 1932-6203. ; 10:3
  • Tidskriftsartikel (refereegranskat)abstract
    • We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, P-inter= 2.6 x 10(-8)). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDAR-ADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10(-8)), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10(-8)), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10(-4)). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
  • Nikpay, Majid, et al. (författare)
  • A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
  • 2015
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718 .- 1061-4036. ; 47:10, s. 1121-1121
  • Tidskriftsartikel (refereegranskat)abstract
    • Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of similar to 185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
  • O'Seaghdha, Conall M., et al. (författare)
  • Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
  • 2013
  • Ingår i: PLOS Genetics. - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
  • Tidskriftsartikel (refereegranskat)abstract
    • Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
  • Tohry, A., et al. (författare)
  • A comparative study between the adsorption mechanisms of sodium co-silicate and conventional depressants for the reverse anionic hematite flotation
  • 2021
  • Ingår i: Separation science and technology (Print). - : Taylor & Francis. - 0149-6395 .- 1520-5754.
  • Tidskriftsartikel (refereegranskat)abstract
    • Starch, dextrin, sodium silicate (SS), and recently sodium co-silicate (SCS) are the most known depressants for the depression of iron oxides through the traditional reverse flotation. However, all these depressants’ adsorption mechanisms on the surface of iron oxides and their main associated minerals (silicate and phosphates) through the reverse anionic flotation did not yet been thoroughly investigated. For filling this gap, as a comparative investigation, this study implemented Fourier Transform Infrared Spectroscopy (FTIR), zeta potential measurement, and micro-flotation tests to determine the adsorption mechanisms of these depressants and explored their effects on the floatabilities of pure hematite, quartz, and fluorapatite. Micro-flotation test results illustrated that all the examined depressants could depress hematite in the presence of an anionic collector. Still, the efficiencies of SS and SCS were higher than those of starch and dextrin. SCS had the lowest depression effect on quartz, and fluorapatite floatability compared to other depressants. Surface analyses depicted that dextrin and starch decreased the collector adsorption on the fluorapatite surface, where SCS and SS had a negligible effect on its floatability. The co-existence of physical and chemical bonds created between dextrin/starch and fluorapatite was the reason for its depression through the anionic reverse flotation.
  • Tohry, A., et al. (författare)
  • Mechanism of humic acid adsorption as a flotation separation depressant on the complex silicates and hematite
  • 2021
  • Ingår i: Minerals Engineering. - : Elsevier. - 0892-6875 .- 1872-9444. ; 162
  • Tidskriftsartikel (refereegranskat)abstract
    • Humic acid (HA), as an environmentally friendly depressant, absorbed significant attention for possible cleaner production within mineral separation by selective separation, especially for reverse flotation of iron oxides. However, a few systematic studies were addressed its effect on the iron ore reverse cationic flotation in the presence of complex silicates and its adsorption mechanism on the surface of these minerals. This work is going to fill this gap by exploring the depression mechanisms of HA through the reverse cationic flotation (separation of hematite from complex silicates; augite and hornblende). Wettability analyses, micro and batch flotation scale tests were employed for such a purpose. Adsorption test, turbidity measurement, zeta potential measurement, and Fourier Transform Infrared (FTIR) analyses were conducted to understand HA adsorption's mechanism on these minerals' surface. Results relieved that at the low concentration of HA (20 mg/L), adsorption on the examined minerals' surface occurred. Based on the micro-flotation test results, HA's depression impact has the following order: hematite ≫ augite > hornblende. The surface analysis results suggested that HA can interact with the Fe ions on the hematite surface by chemical and hydrogen bonding. The same mechanism was observed for HA adsorption on the considered silicates; however, the adsorption rate was lower, while lower polyvalent cations are available on these silicates' surface.
  • Tohry, A., et al. (författare)
  • Tannin : An eco-friendly depressant for the green flotation separation of hematite from quartz
  • 2021
  • Ingår i: Minerals Engineering. - : Elsevier. - 0892-6875 .- 1872-9444. ; 168
  • Tidskriftsartikel (refereegranskat)abstract
    • Reverse cationic flotation is the most known beneficiation method for the separation of fine hematite particles from silicates. In this process, the depression of the hematite surface is an essential factor. Thus, the development of environmentally friendly depressants plays a critical role. Tannin (TA) as a natural and eco-friendly organic reagent has not yet been considered for such a purpose. Through the reverse cationic flotation, the depression effect of TA was investigated by single and mixture of minerals. Micro-flotation tests and wettability analysis based on contact angle measurements by the captive bubble method (CBM) were conducted. The surface adsorption mechanism of TA on the hematite and quartz was explored through turbidity, zeta-potential measurements, surface adsorption tests, and Fourier transform infrared (FT-IR) analyses. The micro-flotation results indicated that TA could selectively depress more than 90% of hematite, while its effect on quartz floatability was negligible (<8% depressing). Surface wettability analysis demonstrated that TA in the presence of 30 mg/L collector could significantly increase the work of adhesion of hematite from 135.5 to 143.1 erg/cm2, whereas it increased the work of adhesion of quartz from 117.1 to 120.7 erg/cm2. Surface adsorption analysis depicted that in the presence of 100 mg/L TA, the adsorption amount of TA on the hematite surface was 0.99 mg/g, while this amount for quartz was 0.17 mg/g (around 6 times lower than hematite). Turbidity measurements, applied to clarify the aggregation – dispersion behavior of pure minerals in the TA presence, showed that TA had a dispersion effect on the quartz particles, whereas TA caused hematite aggregation. Surface analyses proved that TA selective adsorption occurred on the hematite surface mainly by chemisorption. In contrast, poor physical adsorption was the main interaction between TA and the quartz surface.
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  • Föregående 1...5678910[11]
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