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121.
  • Wagner, Jakob, et al. (författare)
  • Surface texturing of Mo-V-Te-Nb-O-x selective oxidation catalysts
  • 2006
  • Ingår i: Topics in Catalysis. - : Springer. - 1572-9028. ; 38:1-3, s. 51-58
  • Tidskriftsartikel (refereegranskat)abstract
    • The paper concentrates on the study of Mo-V-Te-Nb oxide mixtures by electron microscopy combined with catalytic investigation of these materials in the partial oxidation of propane. Surface texturing of catalyst particles composed of two phases referred to in the literature as M1 and M2 is revealed by high-resolution transmission electron microscopy of high performing catalysts. The chemical composition of the catalyst surface is modified by treatment in water to obtain a significant increment in yield of acrylic acid. A chemical realization of the site isolation concept recurring on a supramolecular arrangement of catalyst and reactant rather than on atomic site isolation is suggested. A complex Mo-V-Te-Nb-O (x) precursor phase carries nanoparticles made from a network of oxoclusters active as catalyst for the conversion of propane to acrylic acid. The designed synthesis of the multi-element oxide bulk and of the surface structure with a different composition than the precursor phase improved the performance by a factor of 4.
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122.
  • Wagner, Nils, et al. (författare)
  • Deep learning-enhanced light-field imaging with continuous validation
  • 2020
  • Annan publikation (övrigt vetenskapligt)abstract
    • Light field microscopy (LFM) has emerged as a powerful tool for fast volumetric image acquisition in biology, but its effective throughput and widespread use has been hampered by a computationally demanding and artefact-prone image reconstruction process. Here, we present a novel framework consisting of a hybrid light-field light-sheet microscope and deep learning-based volume reconstruction, where single light-sheet acquisitions continuously serve as training data and validation for the convolutional neural network reconstructing the LFM volume. Our network delivers high-quality reconstructions at video-rate throughput and we demonstrate the capabilities of our approach by imaging medaka heart dynamics and zebrafish neural activity.
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123.
  • Wagner, Nils, et al. (författare)
  • Deep learning-enhanced light-field imaging with continuous validation
  • 2021
  • Ingår i: Nature Methods. - : Nature Publishing Group. - 1548-7105. ; 18:5, s. 557-563
  • Tidskriftsartikel (refereegranskat)abstract
    • Visualizing dynamic processes over large, three-dimensional fields of view at high speed is essential for many applications in the life sciences. Light-field microscopy (LFM) has emerged as a tool for fast volumetric image acquisition, but its effective throughput and widespread use in biology has been hampered by a computationally demanding and artifact-prone image reconstruction process. Here, we present a framework for artificial intelligence-enhanced microscopy, integrating a hybrid light-field light-sheet microscope and deep learning-based volume reconstruction. In our approach, concomitantly acquired, high-resolution two-dimensional light-sheet images continuously serve as training data and validation for the convolutional neural network reconstructing the raw LFM data during extended volumetric time-lapse imaging experiments. Our network delivers high-quality three-dimensional reconstructions at video-rate throughput, which can be further refined based on the high-resolution light-sheet images. We demonstrate the capabilities of our approach by imaging medaka heart dynamics and zebrafish neural activity with volumetric imaging rates up to 100 Hz.
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124.
  • Wallgren, Jakob, 1987-, et al. (författare)
  • Structure elucidation of urinary metabolites of fentanyl and five fentanyl analogues using LC-QTOF-MS, hepatocyte incubations and synthesized reference standards
  • 2020
  • Ingår i: Journal of Analytical Toxicology. - : Oxford University Press. - 0146-4760 .- 1945-2403. ; 44:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Fentanyl analogues constitute a particularly dangerous group of new psychoactive compounds responsible for many deaths around the world. Little is known about their metabolism and studies utilizing LC-QTOF-MS analysis of hepatocyte incubations and/or authentic urine samples does not allow for determination of the exact metabolite structures, especially when it comes to hydroxylated metabolites. In this study seven motifs (2-, 3-, 4- and β-OH as well as 3,4-diOH, 4-OH-3-OMe and 3-OH-4-OMe) of fentanyl and five fentanyl analogues, acetylfentanyl, acrylfentanyl, cyclopropylfentanyl, isobutyrylfentanyl and 4F-isobutyrylfentanyl were synthesized. The reference standards were analyzed by LC-QTOF-MS, which enabled identification of the major metabolites formed in hepatocyte incubations of the studied fentanyls. By comparison with our previous data sets, major urinary metabolites could tentatively be identified. For all analogues, β-OH, 4-OH and 4-OH-3-OMe were identified after hepatocyte incubation. β-OH was the major hydroxylated metabolite for all studied fentanyls, except for acetylfentanyl where 4-OH was more abundant. However, the ratio 4-OH/β-OH was higher in urine samples than in hepatocyte incubations for all studied fentanyls. Also, 3-OH-4-OMe was not detected in any hepatocyte samples, indicating a clear preference for the 4-OH-3-OMe, which was also found to be more abundant in urine compared to hepatocytes. The patterns appear to be consistent across all studied fentanyls and could serve as a starting point in the development of methods and synthesis of reference standards of novel fentanyl analogues where nothing is known about the metabolism.
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125.
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126.
  • White, Christopher J., et al. (författare)
  • SLOW-SPEED SUPERNOVAE FROM THE PALOMAR TRANSIENT FACTORY : TWO CHANNELS
  • 2015
  • Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 799:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Since the discovery of the unusual prototype SN 2002cx, the eponymous class of Type I (hydrogen-poor) supernovae with low ejecta speeds has grown to include approximately two dozen members identified from several heterogeneous surveys, in some cases ambiguously. Here we present the results of a systematic study of 1077 Type I supernovae discovered by the Palomar Transient Factory, leading to nine new members of this peculiar class. Moreover, we find there are two distinct subclasses based on their spectroscopic, photometric, and host galaxy properties: SN 2002cx-like supernovae tend to be in later-type or more irregular hosts, have more varied and generally dimmer luminosities, have longer rise times, and lack a Ti II trough when compared to SN 2002es-like supernovae. None of our objects show helium, and we counter a previous claim of two such events. We also find that the occurrence rate of these transients relative to Type Ia supernovae is 5.6(-3.8)(+22) % (90% confidence), lower compared to earlier estimates. Combining our objects with the literature sample, we propose that these subclasses have two distinct physical origins.
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127.
  • Wikström, Johan, et al. (författare)
  • Sediment Remediation with New Composite Sorbent Amendments to Sequester Phosphorus, Organic Contaminants, and Metals
  • 2021
  • Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 55:17, s. 11937-11947
  • Tidskriftsartikel (refereegranskat)abstract
    • This study tested two sediment amendments with active sorbents: injection of aluminum (Al) into sediments and thin-layer capping with Polonite (calcium-silicate), with and without the addition of activated carbon (AC), for their simultaneous sequestration of sediment phosphorus (P), hydrophobic organic contaminants (HOCs), and metals. Sediment cores were collected from a eutrophic and polluted brackish water bay in Sweden and incubated in the laboratory to measure sediment-to-water contaminant release and effects on biogeochemical processes. We used diffusive gradients in thin-film passive samplers for metals and semi-permeable membrane devices for the HOC polychlorinated biphenyls and polycyclic aromatic hydrocarbons. Al injection into anoxic sediments completely stopped the release of P and reduced the release of cadmium (Cd, -97%) and zinc (Zn, -95%) but increased the sediment fluxes of PAH (+49%), compared to the untreated sediment. Polonite mixed with AC reduced the release of P (-70%), Cd (-67%), and Zn (-89%) but increased methane (CH4) release. Adding AC to the Al or Polonite reduced the release of HOCs by 40% in both treatments. These results not only demonstrate the potential of innovative remediation techniques using composite sorbent amendments but also highlight the need to assess possible ecological side effects on, for example, sedimentary microbial processes.
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128.
  • Wu, Xifeng, et al. (författare)
  • A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
  • 2012
  • Ingår i: Human Molecular Genetics. - 0964-6906 .- 1460-2083. ; 21:2, s. 456-462
  • Tidskriftsartikel (refereegranskat)abstract
    • Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P = 6.07 x 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.
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129.
  • Wu, Xiongyu, et al. (författare)
  • Synthesis and identification of metabolite biomarkers of 25C-NBOMe and 25I-NBOMe
  • 2017
  • Ingår i: Tetrahedron. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0040-4020 .- 1464-5416. ; 73:45, s. 6393-6400
  • Tidskriftsartikel (refereegranskat)abstract
    • Synthetic routes have been developed for synthesis of potential metabolites of 25C-NBOMe and 25I-NBOMe. Nine potential metabolites have been synthesized, among which compounds 8 and 20a could be used as metabolite biomarkers of 25C-NBOMe and 20b of 25I-NBOMe in urinary detection at forensic laboratories to prove intake. (C) 2017 Elsevier Ltd. All rights reserved.
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130.
  • Yengo, Loïc, et al. (författare)
  • A saturated map of common genetic variants associated with human height.
  • 2022
  • Ingår i: Nature. - 1476-4687.
  • Tidskriftsartikel (refereegranskat)abstract
    • Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
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