SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Johnson David C.) "

Sökning: WFRF:(Johnson David C.)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
451.
  • Schvartz, D., et al. (författare)
  • The Human Diabetes Proteome Project (HDPP) : The 2014 update
  • 2015
  • Ingår i: Translational Proteomics. - : Elsevier. - 2212-9626. ; 8-9, s. 1-7
  • Tidskriftsartikel (refereegranskat)abstract
    • Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.
  •  
452.
  • Sherry, Nicole, et al. (författare)
  • Teplizumab for treatment of type 1 diabetes (Protege study): 1-year results from a randomised, placebo-controlled trial
  • 2011
  • Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 378:9790, s. 487-497
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Findings of small studies have suggested that short treatments with anti-CD3 monoclonal antibodies that are mutated to reduce Fc receptor binding preserve beta-cell function and decrease insulin needs in patients with recent-onset type 1 diabetes. In this phase 3 trial, we assessed the safety and efficacy of one such antibody, teplizumab. less thanbrgreater than less thanbrgreater thanMethods In this 2-year trial, patients aged 8-35 years who had been diagnosed with type 1 diabetes for 12 weeks or fewer were enrolled and treated at 83 clinical centres in North America, Europe, Israel, and India. Participants were allocated (2:1:1:1 ratio) by an interactive telephone system, according to computer-generated block randomisation, to receive one of three regimens of teplizumab infusions (14-day full dose, 14-day low dose, or 6-day full dose) or placebo at baseline and at 26 weeks. The Protege study is still underway, and patients and study staff remain masked through to study closure. The primary composite outcome was the percentage of patients with insulin use of less than 0.5 U/kg per day and glycated haemoglobin A(1c) (HbA(1c)) of less than 6-5% at 1 year. Analyses included all patients who received at least one dose of study drug. This trial is registered with ClinicalTrials.gov, number NCT00385697. less thanbrgreater than less thanbrgreater thanFindings 763 patients were screened, of whom 516 were randomised to receive 14-day full-dose teplizumab (n=209), 14-day low-dose teplizumab (n=102), 6-day full-dose teplizumab (n=106), or placebo (n=99). Two patients in the 14-day full-dose group and one patient in the placebo group did not start treatment, so 513 patients were eligible for efficacy analyses. The primary outcome did not differ between groups at 1 year: 19.8% (41/207) in the 14-day full-dose group; 13.7% (14/102) in the 14-day low-dose group; 20.8% (22/106) in the 6-day full-dose group; and 20.4% (20/98) in the placebo group. 5% (19/415) of patients in the teplizumab groups were not taking insulin at 1 year, compared with no patients in the placebo group at 1 year (p=0.03). Across the four study groups, similar proportions of patients had adverse events (414/417 [99%] in the teplizumab groups vs 98/99 [99%] in the placebo group) and serious adverse events (42/417 [10%] vs 9/99 [9%]). The most common clinical adverse event in the teplizumab groups was rash (220/417 [53%] vs 20/99 [20%] in the placebo group). less thanbrgreater than less thanbrgreater thanInterpretation Findings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have increased success in prevention of a decline in beta-cell function (measured by C-peptide) and provision of glycaemic control at reduced doses of insulin if they target patients early after diagnosis of diabetes and children.
  •  
453.
  • Stephens, Lucas, et al. (författare)
  • Archaeological assessment reveals Earth's early transformation through land use
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 365:6456, s. 897-902
  • Tidskriftsartikel (refereegranskat)abstract
    • Environmentally transformative human use of land accelerated with the emergence of agriculture, but the extent, trajectory, and implications of these early changes are not well understood. An empirical global assessment of land use from 10,000 years before the present (yr B.P.) to 1850 CE reveals a planet largely transformed by hunter-gatherers, farmers, and pastoralists by 3000 years ago, considerably earlier than the dates in the land-use reconstructions commonly used by Earth scientists. Synthesis of knowledge contributed by more than 250 archaeologists highlighted gaps in archaeological expertise and data quality, which peaked for 2000 yr B.P. and in traditionally studied and wealthier regions. Archaeological reconstruction of global land-use history illuminates the deep roots of Earth's transformation and challenges the emerging Anthropocene paradigm that large-scale anthropogenic global environmental change is mostly a recent phenomenon.
  •  
454.
  • Stephens, Lucas, et al. (författare)
  • Archaeological assessment reveals Earth’s early transformation through land use
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 365:6456, s. 897-902
  • Tidskriftsartikel (refereegranskat)abstract
    • Humans began to leave lasting impacts on Earth’s surface starting 10,000 to 8000 years ago. Through a synthetic collaboration with archaeologists around the globe, Stephens et al. compiled a comprehensive picture of the trajectory of human land use worldwide during the Holocene (see the Perspective by Roberts). Hunter-gatherers, farmers, and pastoralists transformed the face of Earth earlier and to a greater extent than has been widely appreciated, a transformation that was essentially global by 3000 years before the present.Science, this issue p. 897; see also p. 865Environmentally transformative human use of land accelerated with the emergence of agriculture, but the extent, trajectory, and implications of these early changes are not well understood. An empirical global assessment of land use from 10,000 years before the present (yr B.P.) to 1850 CE reveals a planet largely transformed by hunter-gatherers, farmers, and pastoralists by 3000 years ago, considerably earlier than the dates in the land-use reconstructions commonly used by Earth scientists. Synthesis of knowledge contributed by more than 250 archaeologists highlighted gaps in archaeological expertise and data quality, which peaked for 2000 yr B.P. and in traditionally studied and wealthier regions. Archaeological reconstruction of global land-use history illuminates the deep roots of Earth’s transformation and challenges the emerging Anthropocene paradigm that large-scale anthropogenic global environmental change is mostly a recent phenomenon.
  •  
455.
  • Weinhold, Niels, et al. (författare)
  • The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
  • 2013
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718. ; 45:5, s. 522-525
  • Tidskriftsartikel (refereegranskat)abstract
    • A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
  •  
456.
  • Went, Molly, et al. (författare)
  • Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes
  • 2019
  • Ingår i: Human Genomics. - : BioMed Central (BMC). - 1479-7364. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundWhile genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and search for novel risk regions, we performed a multi-tissue transcriptome-wide association study (TWAS).ResultsGWAS data on 7319 MM cases and 234,385 controls was integrated with Genotype-Tissue Expression Project (GTEx) data assayed in 48 tissues (sample sizes, N = 80–491), including lymphocyte cell lines and whole blood, to predict gene expression. We identified 108 genes at 13 independent regions associated with MM risk, all of which were in 1 Mb of known MM GWAS risk variants. Of these, 94 genes, located in eight regions, had not previously been considered as a candidate gene for that locus.ConclusionsOur findings highlight the value of leveraging expression data from multiple tissues to identify candidate genes responsible for GWAS associations which provide insight into MM tumorigenesis. Among the genes identified, a number have plausible roles in MM biology, notably APOBEC3C, APOBEC3H, APOBEC3D, APOBEC3F, APOBEC3G, or have been previously implicated in other malignancies. The genes identified in this TWAS can be explored for follow-up and validation to further understand their role in MM biology.
  •  
457.
  • Whitmore, Bradley C., et al. (författare)
  • LEGUS and H-alpha-LEGUS Observations of Star Clusters in NGC 4449 : Improved Ages and the Fraction of Light in Clusters as a Function of Age
  • 2020
  • Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 889:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new catalog and results for the cluster system of the starburst galaxy NGC 4449, based on multiband imaging observations taken as part of the LEGUS and H-alpha-LEGUS surveys. We improve the spectral energy fitting method used to estimate cluster ages, and find that the results, particularly for older clusters, are in better agreement with those from spectroscopy. The inclusion of H-alpha measurements, the role of stochasticity for low-mass clusters, the assumptions about reddening, and the choices of SSP model and metallicity all have important impacts on the age dating of clusters. A comparison with ages derived from stellar color-magnitude diagrams for partially resolved clusters shows reasonable agreement, but large scatter in some cases. The fraction of light found in clusters relative to the total light (i.e., T-L) in the U, B, and V filters in 25 different approximate to kiloparsec-size regions throughout NGC 4449 correlates with both the specific region luminosity, R-L, and the dominant age of the underlying stellar population in each region. The observed cluster age distribution is found to decline over time as dN/d tau proportional to tau(gamma), with gamma = -0.85 +/- 0.15, independent of cluster mass, and is consistent with strong, early cluster disruption. The mass functions of the clusters can be described by a power law with dN/dM proportional to M-beta and beta = -1.86 +/- 2, independent of cluster age. The mass and age distributions are quite resilient to differences in age-dating methods. There is tentative evidence for a factor of 2-3 enhancement in both the star and cluster formation rate approximate to 100-300 Myr ago, indicating that cluster formation tracks star formation generally. The enhancement is probably associated with an earlier interaction event.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (443)
forskningsöversikt (13)
bokkapitel (1)
Typ av innehåll
refereegranskat (453)
övrigt vetenskapligt (4)
Författare/redaktör
Jia, J. (147)
Milov, A. (146)
Kwon, Y. (145)
Deshpande, A (142)
Nakamura, T. (141)
Lebedev, A. (141)
visa fler...
Goto, Y (140)
Bathe, S. (139)
Buesching, H. (139)
Chujo, T. (139)
Glenn, A. (139)
Hamagaki, H. (139)
Miake, Y. (139)
Esumi, S. (139)
Alexander, J (139)
Hong, B (139)
Watanabe, Y. (139)
Akiba, Y. (139)
Bazilevsky, A (139)
Bumazhnov, V. (139)
Chiu, M (139)
Cianciolo, V (139)
David, G (139)
Denisov, A (139)
Drees, A (139)
Durum, A (139)
Franz, A (139)
He, X (139)
Homma, K (139)
Ichihara, T (139)
Kurita, K (139)
Lacey, R (139)
O'Brien, E (139)
Saito, N (139)
Sakaguchi, T (139)
Stenlund, Evert (138)
Tanaka, Y. (138)
Sugitate, T. (138)
Baublis, V (138)
Butsyk, S (138)
Hayano, R (138)
Kistenev, E (138)
Nagamiya, S (138)
Papavassiliou, V (138)
Ravinovich, I (138)
Rosati, M (138)
Sawada, S (138)
Seto, R (138)
Taketani, A (138)
Tserruya, I (138)
visa färre...
Lärosäte
Lunds universitet (256)
Uppsala universitet (114)
Karolinska Institutet (81)
Umeå universitet (50)
Göteborgs universitet (33)
Chalmers tekniska högskola (31)
visa fler...
Stockholms universitet (24)
Kungliga Tekniska Högskolan (13)
Högskolan Dalarna (9)
Linköpings universitet (7)
Sveriges Lantbruksuniversitet (5)
Örebro universitet (3)
Jönköping University (2)
Naturhistoriska riksmuseet (2)
Mittuniversitetet (1)
Linnéuniversitetet (1)
Högskolan i Borås (1)
Karlstads universitet (1)
visa färre...
Språk
Engelska (457)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (242)
Medicin och hälsovetenskap (198)
Teknik (9)
Samhällsvetenskap (6)
Lantbruksvetenskap (3)
Humaniora (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy