SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kuh D) "

Sökning: WFRF:(Kuh D)

  • Resultat 31-40 av 66
  • Föregående 123[4]567Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
31.
  • Hagg, S., et al. (författare)
  • Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
  • 2017
  • Ingår i: Translational Psychiatry. - 2158-3188 .- 2158-3188. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N = 17 052; mean age = 59.2 +/- 8.8 years) provided results for associations between qPCR-measuredTL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL including seven known genetic variants for TL was calculated, and used in associations with cognitive traits as outcomes in all cohorts. Observational analyses showed that longer telomeres were associated with better scores on DSST (beta = 0.051 per s. d.-increase of TL; 95% confidence interval (CI): 0.024, 0.077; P = 0.0002), and MMSE (beta = 0.025; 95% CI: 0.002, 0.047; P = 0.03), and faster STROOP (beta = -0.053; 95% CI: -0.087, -0.018; P = 0.003). Effects for DSST were stronger in APOE epsilon 4 non-carriers (beta = 0.081; 95% CI: 0.045, 0.117; P = 1.0 x 10(-5)), whereas carriers performed better in STROOP (beta = -0.074; 95% CI: -0.140, -0.009; P = 0.03). Causal associations were found for STROOP only (beta = -0.598 per s. d.-increase of TL; 95% CI: -1.125, -0.072; P = 0.026), with a larger effect in epsilon 4-carriers (beta = -0.699; 95% CI: -1.330, -0.069; P = 0.03). Two-sample replication analyses using CHARGE summary statistics showed causal effects between TL and general cognitive function and DSST, but not with STROOP. In conclusion, we suggest causal effects from longer TL on better cognitive performance, where APOE epsilon 4-carriers might be at differential risk.
  •  
32.
  •  
33.
  • Willer, Cristen J., et al. (författare)
  • Discovery and refinement of loci associated with lipid levels
  • 2013
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
  • Tidskriftsartikel (refereegranskat)abstract
    • Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
  •  
34.
  •  
35.
  • Berndt, Sonja I., et al. (författare)
  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
  • 2013
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1546-1718 .- 1061-4036. ; 45:5, s. 501-512
  • Tidskriftsartikel (refereegranskat)abstract
    • Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
  •  
36.
  •  
37.
  •  
38.
  •  
39.
  •  
40.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 31-40 av 66
  • Föregående 123[4]567Nästa
Typ av publikation
tidskriftsartikel (63)
Typ av innehåll
refereegranskat (63)
övrigt vetenskapligt (3)
Författare/redaktör
Kuh, D (42)
Hardy, R (25)
Kuh, Diana (18)
Wong, Andrew (18)
Wilson, James F. (17)
Wong, A (16)
visa fler...
Kumari, Meena (16)
Campbell, Harry (15)
Rudan, Igor (15)
Wareham, Nicholas J. (15)
Hamsten, Anders (15)
Loos, Ruth J F (15)
Hayward, Caroline (15)
Kivimaki, Mika (15)
Hofman, Albert (14)
Uitterlinden, Andre ... (14)
Kuusisto, Johanna (14)
Laakso, Markku (14)
McCarthy, Mark I (14)
Ridker, Paul M. (14)
Chasman, Daniel I. (14)
Langenberg, Claudia (14)
Boehnke, Michael (14)
Tuomilehto, Jaakko (14)
Mangino, Massimo (14)
Kleber, Marcus E. (14)
Salomaa, Veikko (13)
Mohlke, Karen L (13)
Abecasis, Goncalo R. (13)
Gieger, Christian (13)
Watkins, Hugh (13)
Ong, Ken K. (13)
Snieder, Harold (13)
Goel, Anuj (13)
Jackson, Anne U. (13)
Luan, Jian'an (13)
Perola, Markus (12)
Gudnason, Vilmundur (12)
Van Duijn, Cornelia ... (12)
Strachan, David P (12)
Deloukas, Panos (12)
Spector, Tim D. (12)
Barroso, Ines (12)
Metspalu, Andres (12)
Farrall, Martin (12)
Hicks, Andrew A. (12)
Pramstaller, Peter P ... (12)
Rivadeneira, Fernand ... (12)
Harris, Tamara B (12)
Boerwinkle, Eric (12)
visa färre...
Lärosäte
Karolinska Institutet (32)
Lunds universitet (25)
Göteborgs universitet (16)
Uppsala universitet (14)
Umeå universitet (7)
Stockholms universitet (3)
visa fler...
Kungliga Tekniska Högskolan (2)
Linköpings universitet (1)
Högskolan i Skövde (1)
visa färre...
Språk
Engelska (66)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (32)
Naturvetenskap (3)
Samhällsvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy