SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lecoeur Cécile) "

Sökning: WFRF:(Lecoeur Cécile)

  • Resultat 21-23 av 23
  • Föregående 12[3]
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  • Palmer, Nicholette D, et al. (författare)
  • A genome-wide association search for type 2 diabetes genes in African Americans.
  • 2012
  • Ingår i: PLOS ONE. - San Francisco : Public Library of Science. - 1932-6203. ; 7:1, s. e29202-
  • Tidskriftsartikel (refereegranskat)abstract
    • African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
  •  
22.
  • Prokopenko, Inga, et al. (författare)
  • A Central Role for GRB10 in Regulation of Islet Function in Man.
  • 2014
  • Ingår i: PLoS Genetics. - : Public Library of Science. - 1553-7404 .- 1553-7390. ; 10:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.
  •  
23.
  • Sverrisdóttir, Oddný Ósk, et al. (författare)
  • Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe
  • 2014
  • Ingår i: Molecular biology and evolution. - 0737-4038 .- 1537-1719. ; 31:4, s. 975-983
  • Tidskriftsartikel (refereegranskat)abstract
    • Lactase persistence (LP) is a genetically determined trait whereby the enzyme lactase is expressed throughout adult life. Lactase is necessary for the digestion of lactose-the main carbohydrate in milk-and its production is downregulated after the weaning period in most humans and all other mammals studied. Several sources of evidence indicate that LP has evolved independently, in different parts of the world over the last 10,000 years, and has been subject to strong natural selection in dairying populations. In Europeans, LP is strongly associated with, and probably caused by, a single C to T mutation 13,910 bp upstream of the lactase (LCT) gene (-13,910*T). Despite a considerable body of research, the reasons why LP should provide such a strong selective advantage remain poorly understood. In this study, we examine one of the most widely cited hypotheses for selection on LP-that fresh milk consumption supplemented the poor vitamin D and calcium status of northern Europe's early farmers (the calcium assimilation hypothesis). We do this by testing for natural selection on -13,910*T using ancient DNA data from the skeletal remains of eight late Neolithic Iberian individuals, whom we would not expect to have poor vitamin D and calcium status because of relatively high incident UVB light levels. None of the eight samples successfully typed in the study had the derived T-allele. In addition, we reanalyze published data from French Neolithic remains to both test for population continuity and further examine the evolution of LP in the region. Using simulations that accommodate genetic drift, natural selection, uncertainty in calibrated radiocarbon dates, and sampling error, we find that natural selection is still required to explain the observed increase in allele frequency. We conclude that the calcium assimilation hypothesis is insufficient to explain the spread of LP in Europe.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-23 av 23
  • Föregående 12[3]
Typ av publikation
tidskriftsartikel (23)
Typ av innehåll
refereegranskat (23)
Författare/redaktör
Lecoeur, Cecile (27)
Wareham, Nicholas J (24)
Froguel, Philippe (23)
Loos, Ruth J F (21)
Jackson, Anne U. (21)
McCarthy, Mark I (20)
visa fler...
Barroso, Ines (20)
Collins, Francis S. (19)
Mohlke, Karen L (17)
Wilson, James F. (17)
Bonnycastle, Lori L. (17)
Kuusisto, Johanna (16)
Laakso, Markku (16)
Meigs, James B. (16)
Prokopenko, Inga (16)
Stumvoll, Michael (16)
Bornstein, Stefan R. (16)
Watanabe, Richard M. (16)
Groop, Leif (15)
Langenberg, Claudia (15)
Boehnke, Michael (15)
Kovacs, Peter (15)
Dupuis, Josée (15)
Frayling, Timothy M (15)
Chines, Peter S. (15)
Florez, Jose C. (15)
Boomsma, Dorret I. (14)
Tuomilehto, Jaakko (14)
Morris, Andrew P (14)
Lindgren, Cecilia M. (14)
Stringham, Heather M ... (14)
Fox, Caroline S. (14)
Bergman, Richard N. (14)
Erdos, Michael R (14)
Morken, Mario A (14)
Wareham, NJ (13)
Psaty, Bruce M. (13)
Van Duijn, Cornelia ... (13)
Deloukas, Panos (13)
Froguel, P (13)
Hu, Frank B. (13)
Shuldiner, Alan R. (13)
Prokopenko, I (13)
Wright, Alan F. (13)
Thorleifsson, Gudmar (13)
Stefansson, Kari (13)
Pankow, James S. (13)
Voight, Benjamin F. (13)
Stumvoll, M (13)
Lecoeur, C (13)
visa färre...
Lärosäte
Uppsala universitet (12)
Lunds universitet (11)
Göteborgs universitet (7)
Umeå universitet (7)
Stockholms universitet (1)
Örebro universitet (1)
visa fler...
Karolinska Institutet (1)
visa färre...
Språk
Engelska (23)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (19)
Naturvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy