SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Lewis Victor A) "

Sökning: WFRF:(Lewis Victor A)

  • Resultat 21-23 av 23
  • Föregående 12[3]
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  • Tsilidis, Konstantinos K., et al. (författare)
  • Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent : a Mendelian randomization study
  • 2021
  • Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 113:6, s. 1490-1502
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.OBJECTIVES: To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR). METHODS: Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.CONCLUSIONS: These results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.
  •  
22.
  • Garvican-Lewis, Laura A., et al. (författare)
  • Influence of combined iron supplementation and simulated hypoxia on the haematological module of the athlete biological passport
  • 2018
  • Ingår i: Drug Testing and Analysis. - 1942-7603 .- 1942-7611. ; 10:4, s. 731-741
  • Tidskriftsartikel (refereegranskat)abstract
    • The integrity of the athlete biological passport (ABP) is underpinned by understanding normal fluctuations of its biomarkers to environmental or medical conditions, for example, altitude training or iron deficiency. The combined impact of altitude and iron supplementation on the ABP was evaluated in endurance-trained athletes (n = 34) undertaking 3 weeks of simulated live-high: train-low (14 h.d(-1), 3000 m). Athletes received either oral, intravenous (IV) or placebo iron supplementation, commencing 2 weeks prior and continuing throughout hypoxic exposure. Venous blood was sampled twice prior, weekly during, and up to 6 weeks after altitude. Individual ABP thresholds for haemoglobin concentration ([Hb]), reticulocyte percentage (%retic), and OFF score were calculated using the adaptive model and assessed at 99% and 99.9% specificity. Eleven athletes returned values outside of the calculated reference ranges at 99%, with 8 at 99.9%. The percentage of athletes exceeding the thresholds in each group was similar, but IV returned the most individual occurrences. A similar frequency of abnormalities occurred across the 3 biomarkers, with abnormal [Hb] and OFF score values arising mainly during-, and %retic values mainly post-altitude. Removing samples collected during altitude from the model resulted in 10 athletes returning abnormal values at 99% specificity, 2 of whom had not triggered the model previously. In summary, the abnormalities observed in response to iron supplementation and hypoxia were not systematic and mostly in line with expected physiological adaptations. They do not represent a uniform weakness in the ABP. Nevertheless, altitude training and iron supplementation should be carefully considered by experts evaluating abnormal ABP profiles.
  •  
23.
  • Garvican-Lewis, Laura A., et al. (författare)
  • Intravenous Iron Does Not Augment the Hemoglobin Mass Response to Simulated Hypoxia
  • 2018
  • Ingår i: Medicine & Science in Sports & Exercise. - 0195-9131 .- 1530-0315. ; 50:8, s. 1669-1678
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose Iron is integral for erythropoietic adaptation to hypoxia, yet the importance of supplementary iron compared with existing stores is poorly understood. The aim of the present study was to compare the magnitude of the hemoglobin mass (Hb(mass)) in response to altitude in athletes with intravenous (IV), oral, or placebo iron supplementation. Methods Thirty-four, nonanemic, endurance-trained athletes completed 3 wk of simulated altitude (3000 m, 14 hd(-1)), receiving two to three bolus iron injections (ferric carboxymaltose), daily oral iron supplementation (ferrous sulfate), or a placebo, commencing 2 wk before and throughout altitude exposure. Hb(mass) and markers of iron regulation were assessed at baseline (day -14), immediately before (day 0), weekly during (days 8 and 15), and immediately, 1, 3, and 6 wk after (days 22, 28, 42, and 63) the completion of altitude exposure. Results Hb(mass) significantly increased after altitude exposure in athletes with IV (mean % [90% confidence interval (CI)], 3.7% [2.8-4.7]) and oral (3.2% [2.2-4.2]) supplementation and remained elevated at 7 d postaltitude in oral (2.9% [1.5-4.3]) and 21 d after in IV (3.0% [1.5-4.6]) supplementation. Hb(mass) was not significantly higher than baseline at any time point in placebo. Conclusions Iron supplementation appears necessary for optimal erythropoietic adaptation to altitude exposure. IV iron supplementation during 3 wk of simulated live high-train low altitude training offered no additional benefit in terms of the magnitude of the erythropoietic response for nonanemic endurance athletes compared with oral supplementation.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-23 av 23
  • Föregående 12[3]
Typ av publikation
tidskriftsartikel (23)
Typ av innehåll
refereegranskat (23)
Författare/redaktör
Gibbs, Richard A (5)
Maglott, Donna (5)
Ermolaeva, Olga (5)
Kitts, Paul (5)
Nazareth, Lynne V. (5)
Solovyev, Victor (5)
visa fler...
Souvorov, Alexandre (5)
Elhaik, Eran (4)
Elsik, Christine G. (4)
Zhang, Lan (4)
Hlavina, Wratko (4)
Kapustin, Yuri (4)
Pruitt, Kim (4)
Lewis, Lora R (4)
Graur, Dan (4)
Davis, Clay (4)
Hines, Sandra (4)
Hume, Jennifer (4)
Kiryutin, Boris (4)
Pu, Ling-Ling (4)
Reese, Justin T. (4)
Sapojnikov, Victor (4)
Chacko, Joseph (4)
Ashton, Peter (3)
Vattathil, Selina (3)
Muzny, Donna (3)
Robertson, Hugh M (3)
Sodergren, Erica (3)
Worley, Kim C. (3)
Jiang, Huaiyang (3)
Weinstock, George M. (3)
Morgan, Margaret B (3)
Hauser, Frank (3)
Grimmelikhuijzen, Co ... (3)
Chen, Hsiu-Chuan (3)
Dinh, Huyen H. (3)
Dugan-Rocha, Shannon (3)
Fowler, Gerald R. (3)
Hernandez, Judith (3)
Joshi, Vandita (3)
Kriventseva, Evgenia ... (3)
Lee, Sandra (3)
Lozado, Ryan J. (3)
Okwuonu, Geoffrey O. (3)
Ruiz, San Juana (3)
Santibanez, Jireh (3)
Zdobnov, Evgeny M. (3)
Kovar, Christie (3)
Stanke, Mario (3)
Richards, Stephen (3)
visa färre...
Lärosäte
Uppsala universitet (7)
Umeå universitet (6)
Karolinska Institutet (6)
Göteborgs universitet (4)
Mittuniversitetet (3)
Stockholms universitet (2)
visa fler...
Lunds universitet (2)
Sveriges Lantbruksuniversitet (2)
Kungliga Tekniska Högskolan (1)
Högskolan Väst (1)
Örebro universitet (1)
Malmö universitet (1)
Högskolan i Halmstad (1)
Karlstads universitet (1)
visa färre...
Språk
Engelska (23)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (11)
Medicin och hälsovetenskap (10)
Samhällsvetenskap (2)
Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy