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Sökning: WFRF:(Neri R.)

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61.
  • Burillo, S. G., et al. (författare)
  • High-resolution imaging of the molecular outflows in two mergers: IRAS 17208-0014 and NGC 1614
  • 2015
  • Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 580
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. Galaxy evolution scenarios predict that the feedback of star formation and nuclear activity (AGN) can drive the transformation of gas-rich spiral mergers into (ultra) luminous infrared galaxies and, eventually, lead to the build-up of QSO/elliptical hosts. Aims. We study the role that star formation and AGN feedback have in launching and maintaining the molecular outflows in two starburst-dominated advanced mergers, NGC 1614 (DL = 66 Mpc) and IRAS 17208-0014 (DL = 181 Mpc), by analyzing the distribution and kinematics of their molecular gas reservoirs. Both galaxies present evidence of outflows in other phases of their ISM. Methods. We used the Plateau de Bure interferometer (PdBI) to image the CO(10) and CO(21) line emissions in NGC 1614 and IRAS 17208-0014, respectively, with high spatial resolution (0: 0051: 002). The velocity fields of the gas were analyzed and modeled to find the evidence of molecular outflows in these sources and characterize the mass, momentum, and energy of these components. Results. While most (95%) of the CO emission stems from spatially resolved (23 kpc-diameter) rotating disks, we also detect in both mergers the emission from high-velocity line wings that extend up to -500-700 km s1, well beyond the estimated virial range associated with rotation and turbulence. The kinematic major axis of the line-wing emission is tilted by 90 in NGC 1614 and by 180 in IRAS 17208-0014 relative to the major axes of their respective rotating disks. These results can be explained by the existence of non-coplanar molecular outflows in both systems: the outflow axis is nearly perpendicular to the rotating disk in NGC 1614, but it is tilted relative to the angular momentum axis of the rotating disk in IRAS 17208-0014. Conclusions. In stark contrast to NGC 1614, where star formation alone can drive its molecular outflow, the mass, energy, and momentum budget requirements of the molecular outflow in IRAS 17208-0014 can be best accounted for by the existence of a so far undetected (hidden) AGN of LAGN71011 L The geometry of the molecular outflow in IRAS 17208-0014 suggests that the outflow is launched by a non-coplanar disk that may be associated with a buried AGN in the western nucleus.
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62.
  • Burillo, S. G., et al. (författare)
  • Molecular gas chemistry in AGN. II. High-resolution imaging of SiO emission in NGC 1068: shocks or XDR?
  • 2010
  • Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 519:Article Number: A2
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. This paper is part of a multi-species survey of line emission from the molecular gas in the circum-nuclear disk (CND) of the Seyfert 2 galaxy NGC 1068. Unlike in other active galaxies, the intensely star-forming regions in NGC 1068 and the CND can be resolved with current instrumentation. This makes this galaxy an optimal test-bed to probe the effects of AGN on the molecular medium at similar to 100 pc scales. Aims. Single-dish observations have provided evidence that the abundance of silicon monoxide (SiO) in the CND of NGC 1068 is enhanced by 3-4 orders of magnitude with respect to the values typically measured in quiescent molecular gas in the Galaxy. We aim at unveiling the mechanism(s) underlying the SiO enhancement. Methods. We have imaged the emission of the SiO(2-1) (86.8 GHz) and CN(2-1) (226.8 GHz) lines in NGC 1068 at similar to 150 pc and 60 pc spatial resolution with the IRAM Plateau de Bure interferometer (PdBI). We have also obtained complementary IRAM 30 m observations of HNCO and methanol (CH3OH) lines. These species are known as tracers of shocks in the Galaxy. Results. SiO is detected in a disk of similar to 400 pc size around the AGN. SiO abundances in the CND of similar to(1-5) x 10(-9) are about 1-2 orders of magnitude above those measured in the starburst ring. The overall abundance of CN in the CND is high: similar to(0.2-1) x 10(-7). The abundances of SiO and CN are enhanced at the extreme velocities of gas associated with non-circular motions close to the AGN (r
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63.
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64.
  • deSouza, Nandita M., et al. (författare)
  • Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)
  • 2019
  • Ingår i: Insight into Imaging. - : SPRINGEROPEN. - 1869-4101 .- 1869-4101. ; 10:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; these are widely used in scoring coronary artery disease, the arthritides and neurological conditions and for indicating the likelihood of malignancy. However, in an era of machine learning and artificial intelligence, it is increasingly desirable that we extract quantitative biomarkers from medical images that inform on disease detection, characterisation, monitoring and assessment of response to treatment. Quantitation has the potential to provide objective decision-support tools in the management pathway of patients. Despite this, the quantitative potential of imaging remains under-exploited because of variability of the measurement, lack of harmonised systems for data acquisition and analysis, and crucially, a paucity of evidence on how such quantitation potentially affects clinical decision-making and patient outcome. This article reviews the current evidence for the use of semi-quantitative and quantitative biomarkers in clinical settings at various stages of the disease pathway including diagnosis, staging and prognosis, as well as predicting and detecting treatment response. It critically appraises current practice and sets out recommendations for using imaging objectively to drive patient management decisions.
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68.
  • Harreither, Wolfgang, et al. (författare)
  • Carbon Nanotube Fiber Microelectrodes Show a Higher Resistance to Dopamine Fouling
  • 2013
  • Ingår i: Analytical Chemistry. - 0003-2700 .- 1520-6882. ; 85:15, s. 7447-7453
  • Tidskriftsartikel (refereegranskat)abstract
    • We have compared the properties and resistance to DA fouling of a carbon nanotube fiber (CNTF) microelectrode to a traditional carbon fiber (CF) microelectrode. These two materials show comparable electrochemical activities for outer-sphere and inner-sphere redox reactions. Although the CNTF might have a higher intrinsic RC constant, thus limiting its high-frequency behavior, the CNTF shows a significantly higher durability than the CF in terms of electrode stability. During constant oxidation of 100 mu M DA, the signal measured by the CNTF rnicroelectrode shows a 2-h window over which no decrease in current is observed. Under the same conditions, the current obtained at the CF microelectrode decreases by almost 50%. A model of the fouling process, assuming the formation of growing patches of insulator on the surface, has been compared to the data. This model is found to be in good agreement with our results and indicates a growth rate of the patches in the 0.1-2 nm s(-1) range.
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69.
  • Hung, Rayjean J., et al. (författare)
  • Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region
  • 2019
  • Ingår i: Journal of Thoracic Oncology. - : ELSEVIER SCIENCE INC. - 1556-0864 .- 1556-1380. ; 14:8, s. 1360-1369
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer. Methods: We conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer. Results: We detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 x 10(-16)), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 x 10(-16)), and rs4975616 OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 x 10(-14)). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate. Conclusions: We found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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70.
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