| 11. |
- Abdillahi, Suado M, et al.
(författare)
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The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD) : Implications for an in vivo Innate Host Defense Function of Collagen VI
- 2018
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Ingår i: Frontiers in Immunology. - : Frontiers Media S. A.. - 1664-3224. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human commensal commonly residing in the nasopharynx of preschool children. It occasionally causes upper respiratory tract infection such as acute otitis media, but can also spread to the lower respiratory tract causing bronchitis and pneumonia. There is increasing recognition that NTHi has an important role in chronic lower respiratory tract inflammation, particularly in persistent infection in patients suffering from chronic obstructive pulmonary disease (COPD). Here, we set out to assess the innate protective effects of collagen VI, a ubiquitous extracellular matrix component, against NTHi infection in vivo. In vitro, collagen VI rapidly kills bacteria through pore formation and membrane rupture, followed by exudation of intracellular content. This effect is mediated by specific binding of the von Willebrand A (VWA) domains of collagen VI to the NTHi surface adhesins protein E (PE) and Haemophilus autotransporter protein (Hap). Similar observations were made in vivo specimens from murine airways and COPD patient biopsies. NTHi bacteria adhered to collagen fibrils in the airway mucosa and were rapidly killed by membrane destabilization. The significance in host-pathogen interplay of one of these molecules, PE, was highlighted by the observation that it confers partial protection from bacterial killing. Bacteria lacking PE were more prone to antimicrobial activity than NTHi expressing PE. Altogether the data shed new light on the carefully orchestrated molecular events of the host-pathogen interplay in COPD and emphasize the importance of the extracellular matrix as a novel branch of innate host defense.
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| 12. |
- Adelswärd, Rebecka Millhagen
(författare)
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Monument, minne, museum : Stockholms slott under det långa 1900-talet
- 2021
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Doktorsavhandling (övrigt vetenskapligt)abstract
- This study examines how the Royal Palace of Stockholm gradually, from 1880–2000, became established as a monument in art and cultural history, as well as a site of national heritage. The musealisation process of the royal residence is described by analysing the origin of new museal and exhibition milieus, and changes in the palace’s State and Bernadotte Apartments. These measures were taken to enhance and manage this cultural heritage and to make it accessible by using art historical and antiquarian expertise. The thesis discusses the origins of the Palace Museum (1936), Gustav III’s Museum of Antiquities (1958, 1992), the Treasury (1970), the Royal Armoury (1978) and the Tre Kronor Museum (1999). Two periods of consolidation are discernible. First, the façade restoration of 1898–1902, during the reign of king Oskar II, and the completion of the sculpture programme make manifest the late 19th- century positioning of the Tessin palace as a national heritage site. With the appointment of the art historian John Böttiger as Surveyor of the Royal Collections, the king’s commitment to the royal collections led to both object-based scientific research and new conservation practices. Second, collection and exhibition activities evolved during the reign of king Gustaf VI Adolf, 1950–1973, with pronounced educational ambitions and democratic characteristics. The study illuminates the contributions of the palace architects, the role of the Office of the Governor of the Royal Palace and the relationship with the state-run Nationalmuseum and Royal Armoury, which have contributed to continuity in the presentation of historic collections. The thesis demonstrates the importance of art history writing for museal and restoration practices, particularly Stockholms slotts historia 1–3 (1940–1941), a publication decisive in the restoration work in the State and Bernadotte Apartments from the 1940s until the 1970s. The study examines the palace’s dual function as a national monument and royal residence, and how this has been a condition of the musealisation process. Important analytical concepts in the study are musealisation, institutionalisation, professionalisation and scientisation.
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| 13. |
- Andersson, Linus, 1979-, et al.
(författare)
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Chemosensory attention, habituation and detection in women and men
- 2011
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Ingår i: International Journal of Psychophysiology. - : Elsevier. - 0167-8760 .- 1872-7697. ; 79, s. 316-322
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether there are differences between women and men in how chemosensory stimuli are processed. Event-related potentials from 36 participants (18 men) showed that women had larger P3 amplitudes when attending, but not when ignoring CO 2 but not for n-butanol, compared with men. The main finding was that women and men differ in cognitive measures of chemosensory processing.
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| 14. |
- Andersson, Linus, 1979-, et al.
(författare)
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Effects of Task Demands on Olfactory, Auditory, and Visual Event-Related Potentials Suggest Similar Top-Down Modulation Across Senses
- 2018
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Ingår i: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 43:2, s. 129-134
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Tidskriftsartikel (refereegranskat)abstract
- A widely held view is that top-down modulation of sensory information relies on an amodal control network that acts through the thalamus to regulate incoming signals. Olfaction lacks a direct thalamic projection, which suggests that it may differ from other modalities in this regard. We investigated the late positive complex (LPC) amplitudes of event-related potentials (ERP) from 28 participants, elicited by intensity-matched olfactory, auditory and visual stimuli, during a condition of focused attention, a neutral condition, and a condition in which stimuli were to be actively ignored. Amplitudes were largest during the attend condition, lowest during the ignore condition, with the neutral condition in between. A Bayesian analysis resulted in strong evidence for similar effects of task across sensory modalities. We conclude that olfaction, despite its unique neural projections, does not differ from audition and vision in terms of task-dependent neural modulation of the LPC.
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| 15. |
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| 16. |
- Barlind, Jonas G, et al.
(författare)
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Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687)
- 2012
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 55:23, s. 10610-10629
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Tidskriftsartikel (refereegranskat)abstract
- A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and DMPK properties combined with a low predicted dose in man. Rational design and optimization of this series led to the discovery of compound 30 (AZD7687), which met the project objectives for potency, selectivity, in particular over ACAT1, solubility, and preclinical PK profiles. This compound showed the anticipated excellent pharmacokinetic properties in human volunteers.
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| 17. |
- Bengtsson, Jonas, et al.
(författare)
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Therapists' Experiences of Conducting Cognitive Behavioural Therapy Online vis-à-vis Face-to-Face
- 2015
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Ingår i: Cognitive Behaviour Therapy. - Linköping : Informa UK Limited. - 1650-6073 .- 1651-2316. ; 44:6, s. 470-479, s. 18-18
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Tidskriftsartikel (refereegranskat)abstract
- This study has explored therapists' experiences of conducting cognitive behavioural therapy (CBT) online and face-to-face. Eleven therapists partook in semi-structured interviews, which were thematically analysed using an abductive approach. The results indicate that the therapists viewed face-to-face therapy as a stronger experience than Internet-based CBT (ICBT), and the latter as being more manualised, but providing more work-time control. Several participants also thought that working alliance may be achieved faster and more easily in face-to-face therapy, and might worsen with fewer modalities of communication. Clinical implications in need of investigation are whether working with ICBT might buffer therapist exhaustion, and whether this therapy form can be improved by becoming less manual dependant in order to be easier to individualise.
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| 18. |
- Björck, Maria, et al.
(författare)
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Härdar och husgrunder : Arkeologi i det samiska kulturlandskapet i Syd- och Mellansverige
- 2021
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Ingår i: Meta H. - 2002-0406 .- 2002-388X. ; , s. 85-108
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Tidskriftsartikel (refereegranskat)abstract
- Hearths and House foundations: Archaeology in the Sámi cultural landscape of southern andmiddle Sweden: This paper deals with the physical traces of Sámi past in southern andcentral Sweden. From the Norse sagas, and from archaeological sources, there is a mani-fold of evidence of Sámi–Norse interaction and of Sámi presence, and habitation in cen-tral and southern Scandinavia from the Late Iron Age to the Middle Ages. From the earlymodern period there are diverse written sources addressing Sámi habitation in southernScandinavia, and from the 18th century we know of the so-called sockenlappsystemet,an ethnically based, indenture service employing Sámi people. To what degree these earlymodern Sámi kept, and developed traditional practices, has until recently been largelyunknown. Through a combination of sources and methods, from archival studies to fieldsurveys, and excavations, this paper proposes that a strong and continuous developmentof Sámi traditions and practices, though the use of landscape and material culture is vi-sible well into the end of the 19th century
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| 19. |
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| 20. |
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