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  • Björkbacka, Harry, et al. (författare)
  • CD4(+) CD56(+) natural killer T-like cells secreting interferon-γ are associated with incident coronary events.
  • 2016
  • Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 1365-2796 .- 0954-6820. ; 279:1, s. 78-88
  • Tidskriftsartikel (refereegranskat)abstract
    • CD3(+) CD56(+) natural killer T (NKT)-like cells are a subset of T cells characterized by expression of NK receptors and potent antitumour activity. It has also been suggested that they have a role in autoimmune disease, and levels of NKT-like cells are elevated in patients with coronary disease.
  • Borgenvik, Marcus, et al. (författare)
  • Alterations in amino acid concentrations in the plasma and muscle in human subjects during 24 h of simulated adventure racing
  • 2012
  • Ingår i: European Journal of Applied Physiology. - : Springer Science and Business Media LLC. - 1439-6319 .- 1439-6327. ; 112, s. 3679-3688
  • Tidskriftsartikel (refereegranskat)abstract
    • This investigation was designed to evaluate changes in plasma and muscle levels of free amino acids during an ultra-endurance exercise and following recovery. Nine male ultra-endurance trained athletes participated in a 24-h standardized endurance trial with controlled energy intake. The participants performed 12 sessions of running, kayaking and cycling (4 x each discipline). Blood samples were collected before, during and after exercise, as well as after 28 h of recovery. Muscle biopsies were taken 1 week before the test and after exercise, as well as after 28 h of recovery. During the 24-h exercise, plasma levels of branched-chain (BCAA), essential amino acids (EAA) and glutamine fell 13%, 14% and 19% (P<0.05) respectively, whereas their concentrations in muscle were unaltered. Simultaneously, tyrosine and phenylalanine levels rose 38% and 50% (P<0.05) in the plasma and 66% and 46% (P<0.05) in muscle, respectively. After the 24-h exercise, plasma levels of BCAA were positively correlated with muscle levels of glycogen (r2=0.73, P<0.05), as was the combined concentrations of muscle tyrosine and phenylalanine with plasma creatine kinase (r2=0.55, P<0.05). Following 28-h of recovery, plasma and muscle levels of amino acids had either returned to their initial levels or were elevated. In conclusion, ultra-endurance exercise caused significant changes elevations in plasma and muscle levels of tyrosine and phenylalanine, which suggest an increase in net muscle protein breakdown during exercise. There was a reduction in plasma concentrations of EAA and glutamine during exercise, whereas no changes were detected in their muscle concentration after exercise.
  • Building blocks of religion : critical applications and future prospects
  • 2020
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt)abstract
    • The contributions in this book all concern the Building Block Approach to the study of religions as proposed and explored by Professor Ann Taves (University of California, Santa Barbara) during the last 30 years. This approach suggests that analysis of and explanations for complex cultural phenomena such as religion should entail dividing these phenomena into "the constituent parts that interact to produce them", in terms of basic cognitive, psychological and biological proc-esses. In this way, the approach opens up a path to achieving consil-ience between the humanistic, behavioural and natural sciences. The book provides a short and user-friendly introduction to the Building Block Approach suitable for use in the undergraduate classroom as well as by graduate and more advanced scholars. The book opens with a lengthy introduction by Ann Taves and Egil Asprem (Stockholm University, Sweden) outlining the Building Block Approach and its rele-vance for the study of religions. The introduction is followed by seven responses, comments and critiques that identify pros and cons of the approach from different perspectives and areas of study within the larger field of the study of religions. In the concluding chapter, Taves and Asprem provide their responses to the comments and critiques raised.
  • de Jong, Simone, et al. (författare)
  • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
  • 2018
  • Ingår i: Communications Biology. - : Nature Publishing Group. - 2399-3642. ; 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
  • Ekengren, Fredrik, et al. (författare)
  • Sweden in the Delaware Valley: Everyday Life and Material Culture in New Sweden
  • 2013
  • Ingår i: Scandinavian Colonialism and the Rise of Modernity: Small Time Agents in a Global Arena. - : Springer. ; , s. 169-187
  • Bokkapitel (refereegranskat)abstract
    • In 1637 the Swedish Crown, encouraged by Dutch merchants, developed a plan to establish a colonial outpost in America to tap into profitable tobacco and beaver pelt trade. The same year the first cargo ships left Sweden and sailed westwards to claim their piece of America along the Delaware River. Although in many ways unsuccessful and short-lived (the colony collapsed in 1656), New Sweden became a home for generations of colonists. This chapter focuses on the different aspects of their daily life: their longing and desperation, practices of homemaking and domesticating the landscape, their perception and interactions with the neighbouring Native American groups. It discusses the ways material culture was used, exchanged and appropriated by the colonists and the local Lenape and Susquehannock in the processes of meeting, negotiations and daily coexistence.
  • Ekström, Ingrid, 1988-, et al. (författare)
  • Subjective olfactory loss in older adults concurs with long-term odor identification decline
  • 2019
  • Ingår i: Chemical Senses. - Oxford : Oxford University Press. - 0379-864X .- 1464-3553. ; 44:2, s. 105-112
  • Tidskriftsartikel (refereegranskat)abstract
    • Olfactory impairments may provide early indications of future health outcomes in older adults. Thus, an important question concerns whether these impairments can be self-assessed. Previous findings of cross-sectional studies indicate low correlations between self-reported olfactory function and objective olfactory performance. On the other hand, subjective olfactory impairments predict future dementia and mortality in longitudinal settings. No previous study has assessed the relationship between subjectively and objectively measured decline in olfaction over time. Based on data for 903 older adults derived from the Betula Study, a Swedish population-based prospective study, we tested whether rate-of-change in odor identification could be predicted from subjective olfactory decline over a time span of 10 years during which subjective and objective odor functions were assessed on 2 or 3 test occasions. Indeed, we found that participants who experienced subjective olfactory decline over the study period also had significantly steeper rates of decline in odor identification, even after adjusting for demographic, cognitive, and genetic factors that previously have been associated with performance in odor identification. This association was, however, not present in a subsample with baseline cognitive impairment. We interpret these results as evidence that when asked about whether they have an olfactory impairment or not, older persons are assessing intraindividual olfactory changes, rather than interindividual differences. Our results indicate that subjective olfactory loss reflects objective olfactory decline in cognitively intact older adults. This association might be harnessed to predict health outcomes and highlights the need to develop effective olfactory self-assessments.
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