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Sökning: WFRF:(Vijai J)

  • Resultat 61-69 av 69
  • Föregående 123456[7]
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61.
  • Peterlongo, Paolo, et al. (författare)
  • FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.
  • 2015
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 24:18, s. 5345-5355
  • Tidskriftsartikel (refereegranskat)abstract
    • Numerous genetic factors that influence breast cancer risk are known. However, approximately two-thirds of the overall familial risk remain unexplained. To determine whether some of the missing heritability is due to rare variants conferring high to moderate risk, we tested for an association between the c.5791C>T nonsense mutation (p.Arg1931*; rs144567652) in exon 22 of FANCM gene and breast cancer. An analysis of genotyping data from 8635 familial breast cancer cases and 6625 controls from different countries yielded an association between the c.5791C>T mutation and breast cancer risk [odds ratio (OR) = 3.93 (95% confidence interval (CI) = 1.28-12.11; P = 0.017)]. Moreover, we performed two meta-analyses of studies from countries with carriers in both cases and controls and of all available data. These analyses showed breast cancer associations with OR = 3.67 (95% CI = 1.04-12.87; P = 0.043) and OR = 3.33 (95% CI = 1.09-13.62; P = 0.032), respectively. Based on information theory-based prediction, we established that the mutation caused an out-of-frame deletion of exon 22, due to the creation of a binding site for the pre-mRNA processing protein hnRNP A1. Furthermore, genetic complementation analyses showed that the mutation influenced the DNA repair activity of the FANCM protein. In summary, we provide evidence for the first time showing that the common p.Arg1931* loss-of-function variant in FANCM is a risk factor for familial breast cancer.
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65.
  • Awasthi, Mukesh Kumar, et al. (författare)
  • Advanced approaches for resource recovery from wastewater and activated sludge: A review
  • 2023
  • Ingår i: Bioresource Technology. - 0960-8524 .- 1873-2976. ; 384
  • Forskningsöversikt (refereegranskat)abstract
    • Due to resource scarcity, current industrial systems are switching from waste treatment, such as wastewater treatment and biomass, to resource recovery (RR). Biofuels, manure, pesticides, organic acids, and other bioproducts with a great market value can be produced from wastewater and activated sludge (AS). This will not only help in the transition from a linear economy to a circular economy, but also contribute to sustainable development. However, the cost of recovering resources from wastewater and AS to produce value-added products is quite high as compared to conventional treatment methods. In addition, most antioxidant technologies remain at the laboratory scale that have not yet reached the level at industrial scale. In order to promote the innovation of resource recovery technology, the various methods of treating wastewater and AS to produce biofuels, nutrients and energy are reviewed, including biochemistry, thermochemistry and chemical stabilization. The limitations of wastewater and AS treatment methods are prospected from biochemical characteristics, economic and environmental factors. The biofuels derived from third generation feedstocks, such as wastewater are more sustainable. Microalgal biomass are being used to produce biodiesel, bioethanol, biohydrogen, biogas, biooils, bioplastics, biofertilizers, biochar and biopesticides. New technologies and policies can promote a circular economy based on biological materials.
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68.
  • Li, Yue, et al. (författare)
  • Sustainable Conversion of Biowaste to Energy to Tackle the Emerging Pollutants: A Review
  • 2023
  • Ingår i: Current Pollution Reports. - : Springer. - 2198-6592.
  • Forskningsöversikt (refereegranskat)abstract
    • Biowaste is a major source of organic material that can be converted into energy through various processes such as anaerobic digestion, composting, and pyrolysis. However, emerging pollutants, such as pharmaceuticals, pesticides, herbicides, and personal and household products, are a growing concern in wastewater treatment that can be effectively removed by biowaste-to-energy processes. While these contaminants pose significant challenges, the development and implementation of effective monitoring programs and risk assessment tools help to mitigate their impact on human health and the environment. Likewise, monitoring programs, challenges, legislations, and risk assessment tools are essential for understanding and managing the risks associated with emerging pollutants. Biowaste recycling is an important aspect of a biocircular economy perspective as it involves the conversion of organic waste into valuable resources that can be reused sustainably. The review discusses the modern approaches that offer several advantages, including reducing the waste disposal and generating renewable energy while addressing emerging wastewater treatment pollutants. To achieve the goal of a circular economy, modern biotechnological approaches including anaerobic digestion, composting, bioleaching, bioremediation, and microbial fuel cells offer a sustainable and effective way to convert waste into valuable products. These bioproducts alongside energy generation using waste-to-energy technologies can provide economic benefits through revenue generation, reduced waste disposal costs, and improved resource efficiency. To achieve a biocircular economy for biowaste valorization, several stakeholders, including waste collectors, waste management companies, policymakers, and consumers need to be involved. The sustainable conversion of biowaste to energy is an essential and instrumental technology in environmental sustainability.
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69.
  • Yeung, Andy Wai Kan, et al. (författare)
  • Dietary natural products and their potential to influence health and disease including animal model studies
  • 2018
  • Ingår i: Animal Science Papers and Reports. - : POLSKA AKAD NAUK, INST GENETYKI I HODOWLI ZWIERZAT. - 0860-4037. ; 36:4, s. 345-358
  • Forskningsöversikt (refereegranskat)abstract
    • Although biological and pharmacological effects of dietary natural products have been intensively studied, there has been no bibliometric analysis performed on this research field up to now. The current study has aimed to identify and analyze the manuscripts on dietary natural products and their potential to influence health and disease including studies using animal models. Data, including words from titles and abstracts, publication and citation data, have been extracted from Web of Science database and analyzed by the VOSviewer software. Our search has yielded 1,014 manuscripts. The ratio of original articles to reviews was identified to be 1.5:1. Over half of the manuscripts have been published since 2010. The manuscripts have been contributed by 4,301 authors from 1,445 organizations in 76 countries/territories and published in 499 journals. The results from the current study point out that scientific research focusing on the potential of dietary natural products to affect health and disease status (including animal model studies) is expanding, and suggests an increasing significance of this scientific area. With the progressive development and improvement of animal studies, it should be expected that animal models of different human diseases (especially civilization ones) would be an integral part of the research for the evaluation of pharmaceuticals originated from dietary natural products like plants or plant materials. Moreover, natural products can also be fed to animals to improve the quality of animal products, with numerous resulting functional effects.
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  • Resultat 61-69 av 69
  • Föregående 123456[7]

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