| 61. |
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EUROSLA Yearbook 12 (2012)
- 2012
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Ingår i: EUROSLA Yearbook. - Amsterdam : John Benjamins Publishing Company. - 1568-1491.
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Samlingsverk (redaktörskap) (refereegranskat)
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| 62. |
- Freunberger, Dominik, et al.
(författare)
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Is It Time to Reconsider the ‘Gold Standard’ for Nativelikeness in ERP Studies on Grammatical Processing in a Second Language? A Critical Assessment Based on Qualitative Individual Differences
- 2022
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Ingår i: Applied Linguistics. - : Oxford University Press (OUP). - 0142-6001 .- 1477-450X. ; 43:3, s. 433-452
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Tidskriftsartikel (refereegranskat)abstract
- In most event-related potential (ERP) studies on the second language (L2) processing, the native speaker (L1) control group’s grand average ERP pattern serves as the ‘gold standard’ that the L2 group has to reach to be labeled ‘native-like’. This relies on the assumption that the grand average is representative of all or most individuals in a group. Recent research, however, has shown that there can be considerable systematic qualitative variability between individuals even in coherent L1 samples, especially in studies on morphosyntactic processing. We discuss how these qualitative individual differences can undermine previous findings from the gold standard paradigm, and critically assess the main ERP components used as markers for nativelike grammatical processing, namely the left-anterior negativity and the P600. We argue that qualitative variation reflects the dynamics characteristic of nativelike grammatical processing and propose a model for experimental designs that can capture these processing dynamics and, thereby, has the potential to provide a more fine-grained understanding of nativelike attainment in an L2.
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| 63. |
- Garcia-Bennett, Alfonso E., et al.
(författare)
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In vitro generation of motor neuron precursors from mouse embryonic stem cells using mesoporous nanoparticles
- 2014
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Ingår i: Nanomedicine. - 1743-5889 .- 1748-6963. ; 9:16, s. 2457-2466
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Tidskriftsartikel (refereegranskat)abstract
- Aim: Stem cell-derived motor neurons (MNs) are utilized to develop replacement strategies for spinal cord disorders. Differentiation of embryonic stem cells into MN precursors involves factors and their repeated administration. We investigated if delivery of factors loaded into mesoporous nanoparticles could be effective for stem cell differentiation in vitro. Materials & methods: We used a mouse embryonic stem cell line expressing green fluorescent protein under the promoter for the MN-specific gene Hb9 to visualize the level of MN differentiation. The differentiation of stem cells was evaluated by expression of MN-specific transcription factors monitored by quantitative real-time PCR reactions and immunocytochemistry. Results: Mesoporous nanoparticles have strong affiliation to the embryoid bodies, penetrate inside the embryoid bodies and come in contact with differentiating cells. Conclusion: Repeated administration of soluble factors into a culture medium can be avoided due to a sustained release effect using mesoporous silica.
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| 64. |
- Garcia-Bennett, Alfonso, et al.
(författare)
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In vitro generation of motor neuron precursors from mouse embryonic stem cells using mesoporous nanoparticles
- 2014
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Ingår i: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 9:16, s. 2457-2466
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: Stem cell-derived motor neurons (MNs) are utilized to develop replacement strategies for spinal cord disorders. Differentiation of embryonic stem cells into MN precursors involves factors and their repeated administration. We investigated if delivery of factors loaded into mesoporous nanoparticles could be effective for stem cell differentiation in vitro.Materials & methods: We used a mouse embryonic stem cell line expressing green fluorescent protein under the promoter for the MN-specific gene Hb9 to visualize the level of MN differentiation. The differentiation of stem cells was evaluated by expression of MN-specific transcription factors monitored by quantitative real-time PCR reactions and immunocytochemistry.Results: Mesoporous nanoparticles have strong affiliation to the embryoid bodies, penetrate inside the embryoid bodies and come in contact with differentiating cells.Conclusion: Repeated administration of soluble factors into a culture medium can be avoided due to a sustained release effect using mesoporous silica.
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| 65. |
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| 66. |
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| 67. |
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| 68. |
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| 69. |
- Hyltenstam, Kenneth, et al.
(författare)
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Dominant-language replacement. The case of international adoptees
- 2009
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Ingår i: Bilingualism. - 1366-7289 .- 1469-1841. ; 12:2, s. 121-140
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Tidskriftsartikel (refereegranskat)abstract
- This article challenges a recent proposal for the theoretical interpretation of L1 and L2 interaction that results from the abrupt change of language environment in internationally adopted children. According to this proposal (Pallier, Dehaene, Poline, LeBihan, Argenti, Depoux and Mehler, 2003; Ventureyra, Pallier and Yoo, 2004), such children experience a total loss of their L1, while, as adults, they exhibit a nativelike ultimate attainment of their L2. These authors suggest that what they see as a total loss of L1 allows a resetting of the neural network that normally subserves L1 retention and hence permits a complete acquisition of the L2. Data from two of our own research projects, one on L1 remnants in Korean adoptees in Sweden (see Park, forthcoming), and the other on age of acquisition and ultimate L2 attainment of Swedish (see Abrahamsson and Hyltenstam, in press), which included data from Latin American adoptees in Sweden among other participants, suggest (i) that L1 remnants are indeed maintained, (ii) that L2 attainment is not enhanced by severe L1 attrition, and (iii) that there is an age dimension to both the degree of L1 attrition and the level of L2 ultimate attainment in international adoptees. We therefore contend that a maturational interpretation of language replacement data is preferable.
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| 70. |
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