| 1201. |
- Gould, Cathryn M, et al.
(författare)
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ELM : the status of the 2010 eukaryotic linear motif resource.
- 2010
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Ingår i: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 38
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Tidskriftsartikel (refereegranskat)abstract
- Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, linear motifs are difficult to predict de novo in protein sequences due to the difficulty of obtaining robust statistical assessments. The ELM resource at http://elm.eu.org/ provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances. ELM is also an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest. Information about protein domains, protein structure and native disorder, cellular and taxonomic contexts is used to reduce or deprecate false positive matches. Results are graphically displayed in a 'Bar Code' format, which also displays known instances from homologous proteins through a novel 'Instance Mapper' protocol based on PHI-BLAST. ELM server output provides links to the ELM annotation as well as to a number of remote resources. Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation.
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| 1202. |
- Graham, HR, et al.
(författare)
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Pulse oximetry and oxygen services for the care of children with pneumonia attending frontline health facilities in Lagos, Nigeria (INSPIRING-Lagos): study protocol for a mixed-methods evaluation
- 2022
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 12:5, s. e058901-
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this evaluation is to understand whether introducing stabilisation rooms equipped with pulse oximetry and oxygen systems to frontline health facilities in Ikorodu, Lagos State, alongside healthcare worker (HCW) training improves the quality of care for children with pneumonia aged 0–59 months. We will explore to what extent, how, for whom and in what contexts the intervention works.Methods and analysisQuasi-experimental time-series impact evaluation with embedded mixed-methods process and economic evaluation. Setting: seven government primary care facilities, seven private health facilities, two government secondary care facilities. Target population: children aged 0–59 months with clinically diagnosed pneumonia and/or suspected or confirmed COVID-19. Intervention: ‘stabilisation rooms’ within participating primary care facilities in Ikorodu local government area, designed to allow for short-term oxygen delivery for children with hypoxaemia prior to transfer to hospital, alongside HCW training on integrated management of childhood illness, pulse oximetry and oxygen therapy, immunisation and nutrition. Secondary facilities will also receive training and equipment for oxygen and pulse oximetry to ensure minimum standard of care is available for referred children. Primary outcome: correct management of hypoxaemic pneumonia including administration of oxygen therapy, referral and presentation to hospital. Secondary outcome: 14-day pneumonia case fatality rate. Evaluation period: August 2020 to September 2022.Ethics and disseminationEthical approval from University of Ibadan, Lagos State and University College London. Ongoing engagement with government and other key stakeholders during the project. Local dissemination events will be held with the State Ministry of Health at the end of the project (December 2022). We will publish the main impact results, process evaluation and economic evaluation results as open-access academic publications in international journals.Trial registration numberACTRN12621001071819; Registered on the Australian and New Zealand Clinical Trials Registry.
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| 1203. |
- Guilcher, Sara J.T., et al.
(författare)
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Medication self-management toolkits for adults with multiple sclerosis : A scoping review
- 2023
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Ingår i: Exploratory Research in Clinical and Social Pharmacy. - : Elsevier. - 2667-2766. ; 10
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Forskningsöversikt (refereegranskat)abstract
- Background: Multiple sclerosis (MS) is an autoimmune disease that is often treated with multiple medications. Managing multiple medications, also known as polypharmacy, can be challenging for persons with MS. Toolkits are instructional resources designed to promote behaviour change. Toolkits may support medication self-management for adults with MS, as they have been useful in other populations with chronic conditions.Objective: The main purpose of this review was to identify and summarize medication self-management toolkits for MS, as related to the design, delivery, components, and measures used to evaluate implementation and/or outcomes.Methods: A scoping review was conducted following guidelines by JBI. Articles were included if they focused on adults (18 years or older) with MS.Results: Six articles reporting on four unique toolkits were included. Most toolkits were technology-based, including mobile or online applications, with only one toolkit being paper-based. The toolkits varied in type, frequency, and duration of medication management support. Varying outcomes were also identified, but there were improvements reported in symptom management, medication adherence, decision-making, and quality of life. The six studies were quantitative in design, with no studies exploring the user experience from a qualitative or mixed-methods design.Conclusions: There is limited research on medication self-management toolkits among adults with MS. Future development, implementation, and evaluation mixed-methods research are needed to explore user experiences and overall design of toolkits.
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| 1204. |
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| 1205. |
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| 1206. |
- Hamid Muhammed, Hamed, 1967-, et al.
(författare)
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Skin Cancer Detection Using Temperature Variation Analysis
- 2013
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Ingår i: Engineering. - 1947-394X. ; 5:10B
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Tidskriftsartikel (refereegranskat)abstract
- In the medical field, new technologies are incorporated for the sole purpose of enhancing the quality of life for the patients and even for the normal healthy people. Infrared technology is one of the technologies that have some applications in both the medical and biological fields. In this work, the thermal infrared (IR) measurement is used to investigate the potential of skin cancer detection. IR enjoys non-invasive and non-contact advantages as well as favorable cost, apparently. It is also very well developed regarding the technological and methodological aspects. IR per se is an electro-metric radiation that all objects emit when their temperature is above the absolute zero. And the human body is not different in this regard. The IR range extends, ideally, to cover wavelengths from 800 nanometer to few hundred micrometer. Cancer, in modern life, has grown tangibly due to many factors, such as life expectancies increase, personal habits and ultraviolet radiation exposures among others. Moreover, the significant enhancement of technologies has helped identifying more types of cancers than before. The sole purpose of this work is to investigate further IR technology methods and applications not yet matured in skin cancer detection to enhance the detection ability with higher safety level.
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| 1207. |
- Hansson, Henrik, et al.
(författare)
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The Teachers’ Portal as a tool for teachers’ professional development in Bangladesh: : Facilitating nationwide networking and digital multimedia content for 40,000 schools
- 2018
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Ingår i: ijEDict - International Journal of Education and Development using Information and Communication Technology. - 1814-0556. ; 14:3, s. 113-130
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Tidskriftsartikel (refereegranskat)abstract
- The Teachers’ Portal (teachers.gov.bd) is an online platform for Bangladeshi teachers designed to store and retrieve digital educational contents of different subjects useful for classroom teaching and students’ learning. The portal also facilitates professional networking among teachers across the country. This study aims to find out the benefits of using this Portal and associated challenges from teachers’ perspective. Following a mixed methods research approach Teachers, head teachers, teacher educators from primary, secondary, madrasa and vocational educational institutions and specialists on teachers’ Portal (N=410) were interviewed and consulted for the study. Telephone interviews, online surveys, Key Informant Interviews (KII), Focused Group Discussions (FGD), Face-to-Face interviews, and large consultative workshops were used to collect data. The results suggest that teachers are motivated to use the Portal as its contents stimulate students’ creativity and encourage students’ active participation in classrooms learning. Besides, it empowers teachers in a number of ways. However, internet connectivity, slow Internet speed, power failure, technical issues, high cost of Internet and unavailability of equipment are found as major challenges. In short, the Teachers’ Portal is a key driver for changing Bangladeshi education and by so doing preparing the young generation with quality education.
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| 1208. |
- Hao, D., et al.
(författare)
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Solar energy harvesting technologies for PV self-powered applications : A comprehensive review
- 2022
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Ingår i: Renewable energy. - : Elsevier Ltd. - 0960-1481 .- 1879-0682. ; 188, s. 678-697
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Tidskriftsartikel (refereegranskat)abstract
- Many key aspects of society, such as transport, housing and health care, have been significantly improved by the advent of a range of electricity applications, and the power generation for electricity applications has been a major field of research. Photovoltaic (PV) self-powered technologies are promising technologies for addressing applications' power supply challenges and alleviating conventional electricity load and environmental pollution. This study reviews solar energy harvesting (SEH) technologies for PV self-powered applications. First, the PV power generation and scenarios of PV self-powered applications are analyzed. Second, analysis of system design for PV self-powered applications is presented. Third, key components for PV self-powered applications, including maximum power point tracking (MPPT) techniques and power management (PM) systems are discussed in detail. Furthermore, numerous PV self-powered applications and utilizations of energy harvesting are summarized. Finally, some recommendations are proposed for further research.
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| 1209. |
- Hasan, Md. Aziz, 1960-, et al.
(författare)
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Arsenic in shallow groundwater of Bangladesh : investigations from three different physiographic settings
- 2007
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Ingår i: Hydrogeology Journal. - : Springer Science and Business Media LLC. - 1431-2174 .- 1435-0157. ; 15:8, s. 1507-1522
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Tidskriftsartikel (refereegranskat)abstract
- Occurrences of arsenic (As) in the Bengal Basin of Bangladesh show close relationships with depositional environments and sediment textures. Hydrochemical data from three sites with varying physiography and sedimentation history show marked variations in redox status and dissolved As concentrations. Arsenic concentration in groundwater of the Ganges Flood Plain (GFP) is characteristically low, where high Mn concentrations indicate redox buffering by reduction of Mn(IV)-oxyhydroxides. Low DOC, HCO3-, NH4+ and high NO3- and So(4)(2-) concentrations reflect an elevated redox status in GFP aquifers. In contrast, As concentration in the Ganges Delta Plain (GDP) is very high along with high Fe and low Mn. In the Meghna Flood Plain (MFP), moderate to high As and Fe concentrations and low Mn are detected. Degradation of organic matter probably drives redox reactions in the aquifers, particularly in MFP and GDP, thereby mobilising dissolved As. Speciation calculations indicate supersaturation with respect to siderite and vivianite in the groundwater samples at MFP and GDP, but groundwater in the GFP wells is generally supersaturated with respect to rhodochrosite. Values of log P-CO2 at MFP and GDP sites are generally higher than at the GFP site. This is consistent with Mn(IV)-redox buffering suggested at the GFP site compared to Fe(III)-redox buffering at MFP and GDP sites.
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| 1210. |
- Hasan, M. Aziz, et al.
(författare)
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Geological controls on groundwater chemistry and arsenic mobilization : Hydrogeochemical study along an E-W transect in the Meghna basin, Bangladesh
- 2009
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Ingår i: Journal of Hydrology. - : Elsevier BV. - 0022-1694 .- 1879-2707. ; 378:1-2, s. 105-118
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Tidskriftsartikel (refereegranskat)abstract
- Hydrogeochemical investigations along an E-W transect in the middle Meghna basin show groundwater chemistry and redox condition vary considerably with the change in geology. Groundwater in the Holocene shallow (< 150 m bgl) alluvial aquifer in western part of the transect is affected by high arsenic concentration (As > 10 mu g/l) and salinity. On the other hand, groundwater from the Pliocene Dupi Tila sandy aquifer in the eastern part is fresh and low in As (< 10 mu g/l). The Holocene shallow aquifers are high in dissolved As. HCO3-, Fe and dissolved organic carbon (DOC), but generally low in SO2- and NO3-. High HCO3- concentrations (250-716 mg/l) together with high DOC concentrations (1.4-21.7 mg/l) in these aquifers reflect active sources of degradable natural organic matter that drives the biogeochemical process. There is generally de-coupling of As from other redox-sensitive elements. In contrast, the Pliocene aquifers are low in As, HCO3- and DOC. Molar ratio of HCO3-/H4SiO4 suggests that silicate weathering is dominant in the deeper Holocene aquifers and in the Pliocene aquifers. Molar ratios of Cl-/HCO3- and Na+/Cl- suggest mixing of relict seawater with the fresh water as the origin of groundwater salinity. Speciation calculations show that saturation indices for siderite and rhodochrosite vary significantly between the Holocene and Pliocene aquifers. Stable isotopes (delta H-2 and delta O-18) in groundwater indicate rapid infiltration without significant effects of evaporation. The isotopic data also indicates groundwater recharge from monsoonal precipitation with some impact of altitude effect at the base of the Tripura Hills in the east. The results of the study clearly indicate geological control (i.e. change in lithofacies) on groundwater chemistry and distribution of redox-sensitive elements such as As along the transect.
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