| 1271. |
- Hussein, Mohammad H., et al.
(författare)
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Beta 2 -adrenergic receptor gene haplotypes and bronchodilator response in Egyptian patients with chronic obstructive pulmonary disease
- 2017
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Ingår i: Advances in Medical Sciences. - Warsaw, Poland : Elsevier. - 1896-1126 .- 1898-4002. ; 62:1, s. 193-201
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Chronic obstructive pulmonary disease (COPD) is a multi-factorial disorder caused by environmental determinants and genetic risk factors. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens. Beta2-adrenergic receptor (ADRB2) gene polymorphisms have been implicated in the pathogenesis of obstructive pulmonary diseases. This study was conducted to assess the genetic association between Arg16Gly and Gln27Glu polymorphisms and COPD in the Egyptian patients, and to analyze their impact on the clinical outcome and therapeutic response.Patients/methods: The study population included 115 participants (61 COPD patients and 54 healthy controls) were genotyped for the Arg16Gly (rs1042713) and Gln27Glu (rs1042714) polymorphisms. Pulmonary function test was done and repeated in patients after salbutamol inhalation.Results: The Gly16 and Gln27 alleles represented 57% and 70% of the whole study population, and only 3 haplotypes were detected; Arg16/Gln27, Gly16/Gln27, and Gly16/Glu27. Genotypes and haplotypes homozygous for Arg16 and Gln27 were more likely to develop COPD (p<0.05). However, individuals carrying Glu27 allele conferred protection against COPD development (p=0.002). Furthermore, Arg16 genotypes and haplotypes were significantly associated with higher grades of dyspnea, more COPD symptoms and frequent exacerbations. In contrast, patients carrying Glu27 allele had better bronchial airway responsiveness to β2-agonists.Conclusions: Our findings suggested that the ADRB2 gene polymorphisms may have vital role in COPD risk, severity, and bronchodilator response among Egyptian population. Larger epidemiological studies are needed for results validation.
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| 1272. |
- Ibrahim, G.H., et al.
(författare)
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Impact of Interleukin-28B gene polymorphism [rs12979860] on Egyptian patients infected with hepatitis C virus genotype-4
- 2013
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Ingår i: Eastern Mediterranean Health Journal. - Alexandria, Egypt : World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO). - 1020-3397 .- 1687-1634. ; 19:Supp. 3, s. 98-104
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Tidskriftsartikel (refereegranskat)abstract
- Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon-α-ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. A similar role was investigated in a case-control study conducted on 93 Egyptian patients chronically infected with HCV-4 in comparison to 22 individuals with spontaneous HCV clearance and 70 healthy volunteers. The homozygous C allele genotype (CC) was associated with sustained viral response (SVR) to therapy compared with the homozygous T allele genotype (TT) and the heterozygous genotype (CT). In the SVR group, the response rate was statistically significantly higher in CC genotypes (58.6%) compared with CT/TT (20.3%). There was no correlation between SVR patients' genotypes and early response to therapy or HCV baseline viral load. Our findings describe how IL-28B SNP genotyping may guide appropriate selection of HCV-4-infected patients for PR therapy.
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| 1273. |
- Ibupoto, A.S., et al.
(författare)
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Zno/Carbon nanofibers for efficient adsorption of lead from aqueous solutions
- 2020
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Ingår i: Environmental technology. - : Taylor & Francis. - 0959-3330 .- 1479-487X. ; 41:21, s. 2731-2741
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Tidskriftsartikel (refereegranskat)abstract
- Hybrid nanofibers based on ZnO loaded activated carbon nanofibers (ZnO-ACNFs) are proposed here for the elimination of hazardous lead from aqueous solutions. The prepared ZnO nanoscale material was loaded into the polyacrylonitrile nanofibers (PAN NFs) which were later carbonized by using a novel method named as a plate-sandwich method. The Synthesized nanofibrous composite was characterized by SEM, TEM, EDX, FTIR and XRD techniques to analyze its chemical and morphological properties. Moreover, the nanocomposite was efficaciously applied for the lead (Pb2+) ions removal from wastewater and simulated water through continuous filtration and batch filtration. The ZnO-ACNFs membrane showed outstanding results in adsorptive removal, giving adsorption capacity of 92.59 mg/g within the contact time of 45 min. Compared to their counterparts (ZnO and CNFs), the hybrid ZnO-ACNFs showed excellent performance in removing toxic lead.
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| 1274. |
- Iqbal, M. Naeem, et al.
(författare)
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Mesoporous Ruthenium Oxide : A Heterogeneous Catalyst for Water Oxidation
- 2017
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Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 5:11, s. 9651-9656
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Tidskriftsartikel (refereegranskat)abstract
- Herein we report the synthesis of mesoporous ruthenium oxide (MP-RuO2) using a template-based approach. The catalytic efficiency of the prepared MP-RuO2 was compared to commercially available ruthenium oxide nanoparticles (C-RuO2) as heterogeneous catalysts for water oxidation. The results demonstrated superior performance of MP-RuO2 for oxygen evolution compared to the C-RuO2 with respect to recyclability, amount of generated oxygen, and stability over several catalytic runs.
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| 1275. |
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| 1276. |
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| 1277. |
- Islam, Md Aminul, et al.
(författare)
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An Estimation of Five-decade Long Monkeypox Case Fatality Rate : Systematic Review and Meta-analysis
- 2022
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Ingår i: JOURNAL OF PURE AND APPLIED MICROBIOLOGY. - : DR M N KHAN. - 0973-7510. ; 16, s. 3036-3047
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Forskningsöversikt (refereegranskat)abstract
- On July 23, 2022 the World Health Organization (WHO) has announced the Monkeypox disease (MPXD) as a worldwide public health issue. This study conducts a systematic review and meta-analysis to determine the overall case fatality rate (CFR) of MPXD worldwide during 1970-2022. The tenure-tracked MPXD outbreaks associated with CFR were calculated based on available published data from six different periods (i.e., 1970-79, 1980-89, 1990-99, 2000-09, 2010-19, and 2000-2022). A total of 229 peer-reviewed accessible articles were investigated, of which, 17 articles met the inclusion and exclusion criteria. Most of the studies on MPXD CFR were published in the Democratic Republic of the Congo (DRC) providing 47% of data for the current meta-analysis. The overall pooled CFR of MPXD was 4.14% (range: 0.62% - 9.51%) during 1970-2022. In this study, total of 379 death cases were found from published MPXV based research articles where the pooled estimate CFR was 1.87%. The pooled CFR was higher during the earlier outbreak of the MPXD such as 10.71% in 1970-1979. With the progress of time, the CFR from MPXD followed a decreasing trend and reached 5.38% in 1980-1999 and 4.45% in 2000-2022. Young male children aged< 10 years were found to experience the worst outcome with a CFR of >73.0%. This is the first meta-analysis using 52 years of data which indicates that the CFR of MPXV is decreasing from previous years. The findings of this meta-analysis might be paramount for the policymakers to tackle MPXD and minimize the overall CFR of MPXD through strategic actions.
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| 1278. |
- Islam, Md. Aminul, et al.
(författare)
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Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh
- 2022
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Ingår i: Frontiers in Public Health. - : Frontiers Media SA. - 2296-2565. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- In developing countries, acute respiratory infections (ARIs) cause a significant number of deaths among children. According to Bangladesh Demographic and Health Survey (BDHS), about 25% of the deaths in children under-five years are caused by ARI in Bangladesh every year. Low-income families frequently rely on wood, coal, and animal excrement for cooking. However, it is unclear whether using alternative fuels offers a health benefit over solid fuels. To clear this doubt, we conducted a study to investigate the effects of fuel usage on ARI in children. In this study, we used the latest BDHS 2017-18 survey data collected by the Government of Bangladesh (GoB) and estimated the effects of fuel use on ARI by constructing multivariable logistic regression models. From the analysis, we found that the crude (the only type of fuel in the model) odds ratio (OR) for ARI is 1.69 [95% confidence interval (CI): 1.06-2.71]. This suggests that children in families using contaminated fuels are 69.3% more likely to experience an ARI episode than children in households using clean fuels. After adjusting for cooking fuel, type of roof material, child's age (months), and sex of the child-the effect of solid fuels is similar to the adjusted odds ratio (AOR) for ARI (OR: 1.69, 95% CI: 1.05-2.72). This implies that an ARI occurrence is 69.2% more likely when compared to the effect of clean fuel. This study found a statistically significant association between solid fuel consumption and the occurrence of ARI in children in households. The correlation between indoor air pollution and clinical parameters of ARI requires further investigation. Our findings will also help other researchers and policymakers to take comprehensive actions by considering fuel type as a risk factor as well as taking proper steps to solve this issue.
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| 1279. |
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| 1280. |
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