| 51. |
- Madsen, Jakob Torp, et al.
(författare)
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Ethosome formulation of contact allergens may enhance patch test reactions in patients*
- 2010
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Ingår i: CONTACT DERMATITIS. - 0105-1873. ; 63:4, s. 209-214
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Tidskriftsartikel (refereegranskat)abstract
- Background: Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase the allergenicity potential. Objectives: To investigate the effect of ethosome formulation of isoeugenol and methyldibromo glutaronitrile on the elicitation response under patch test conditions and by repeated open applications. Patients/Materials/Methods: A total of 27 volunteer patients with a previous positive patch test reaction to either isoeugenol or methyldibromo glutaronitrile were included in the study. In all patients, a serial dilution patch test was performed with the allergen in question formulated in ethosomes and in an ethanol/water solution. In addition, a repeated open application test (ROAT) was performed in a subset of 16 patients, and lag time until a positive response was recorded. Results: Both contact allergens encapsulated in ethosomes showed significantly enhanced patch test reactions as compared with the allergen preparation in ethanol/water without ethosomes. No significant difference in the median lag time was recorded between preparations in the ROAT. Conclusions: Encapsulating potential contact allergens in ethosomes may increase the challenge response as compared with the same concentrations in an ethanol/water base without ethosomes. © 2010 John Wiley & Sons A/S.
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| 52. |
- Madsen, Jacob Torp, et al.
(författare)
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Ethosome Formulations of Known Contact Allergens can Increase their Sensitizing Capacity
- 2010
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555. ; 90:4, s. 374-378
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Tidskriftsartikel (refereegranskat)abstract
- Vesicular systems, such as liposomes and ethosomes, are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance. Some reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase their contact allergy elicitation potential in humans. However, no sensitization studies have been published. We formulated two model contact allergens (isoeugenol and dinitrochlorobenzene) in ethosomes and investigated the sensitization response using a modified local lymph node assay (LLNA). The results were compared with those for the same allergens in similar concentrations and vehicles without ethosomes. Both allergens encapsulated in 200–300 nm ethosomes showed increased sensitizing potency in the murine assay compared with the allergens in solution without ethosomes. Empty ethosomes were non-sensitizing according to LLNA. The clinical implications are so far uncertain, but increased allergenicity from ethosome-encapsulated topical product ingredients cannot be excluded.
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| 53. |
- Matura, Mihaly, 1964, et al.
(författare)
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Not only oxidized R-(+)- but also S-(-)-limonene is a common cause of contact allergy in dermatitis patients in Europe.
- 2006
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Ingår i: Contact dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 55:5, s. 274-9
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Tidskriftsartikel (refereegranskat)abstract
- Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the oxidized S-limonene. In 57% of the cases, simultaneous reactions were observed to both oxidation mixtures. Concomitant reactions to the fragrance mix, colophonium, Myroxylon pereirae, and fragrance-related contact allergy were common in patients reacting to 1 or both the oxidized limonene enantiomers. Our study provides clinical evidence for the importance of oxidation products of limonene in contact allergy. It seems advisable to screen consecutive dermatitis patients with oxidized limonene 3% petrolatum, although this patch test material is not yet commercially available.
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| 54. |
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| 55. |
- Micci, Francesca, et al.
(författare)
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t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
- 2009
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Ingår i: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 277:2, s. 205-211
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Tidskriftsartikel (refereegranskat)abstract
- The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with sequences from chromosome 21 including the ATP50 gene coding for a mitochondrial ATP synthase. The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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| 56. |
- Morgardt-Ryberg, Kristina, et al.
(författare)
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Patch testing with a textile dye mix - a multicentre study.
- 2014
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 71:4, s. 215-223
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Tidskriftsartikel (refereegranskat)abstract
- Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series.
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| 57. |
- Muris, Joris, et al.
(författare)
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Sensitization to palladium in Europe
- 2015
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 72:1, s. 11-19
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were tested. Relative to 3% Na2PdCl4, 4% Na2PdCl4 did not add any information. Two per cent Na2PdCl4 resulted in more doubtful reactions and showed suboptimal reactivity. The prevalence of palladium sensitization doubled with Na2PdCl4 and was similar to that of nickel. Interestingly, in contrast to nickel sensitization, palladium sensitization was not related to female sex. ConclusionsThree per cent Na2PdCl4 pet. is the most suitable patch test concentration. Sensitization to palladium is almost as prevalent as sensitization to nickel. The sex distribution is different between nickel-sensitized and palladium-sensitized patients, suggesting different sources of exposure.
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| 58. |
- Norsker, Filippa Nyboe, et al.
(författare)
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Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme
- 2020
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Ingår i: Acta Oncologica. - 0284-186X. ; 59:10, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Background: In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed. Methods: In this population-based cohort study we identified 985 five-year soft-tissue sarcoma survivors in Nordic nationwide cancer registries and late effects in national hospital registries covering the period 1964–2012. Information on tumour site and radiotherapy was available for Danish and Finnish survivors (N = 531). Using disease-specific rates of first-time hospital contacts for somatic diseases in survivors and in 4,830 matched comparisons we calculated relative rates (RR) and rate differences (RD). Results: Survivors had a RR of 1.5 (95% CI 1.4–1.7) and an absolute RD of 23.5 (17.7–29.2) for a first hospital contact per 1,000 person-years. The highest risks in both relative and absolute terms were of endocrine disorders (RR = 2.5; RD = 7.6), and diseases of the nervous system (RR = 1.9; RD = 6.6), digestive organs (RR = 1.7; RD = 5.4) and urinary system (RR = 1.7; RD = 5.6). By tumour site, excess risk was lower after extremity tumours. Irradiated survivors had a 2.6 (1.2–5.9) times higher risk than non-irradiated. Conclusions: Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold.
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| 59. |
- Ofenloch, Robert F., et al.
(författare)
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Allergic reactivity for different dilutions of eugenol in repeated open application test and patch testing
- 2023
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Ingår i: Contact Dermatitis. - 0105-1873. ; 89:2, s. 95-102
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Tidskriftsartikel (refereegranskat)abstract
- Background: Eugenol is a known contact sensitiser included in fragrance mix I. Objective: To assess the allergic reactivity to eugenol in different concentrations using patch test as well as repeated open application test (ROAT). Methods: Overall 67 subjects from 6 European dermatology clinics participated in the study. The ROAT was performed for 21 days twice a day, applying 3 dilutions of eugenol (2.7%–0.5%) and a control. Before and after the ROAT, patch testing with 17 dilutions of eugenol (2.0%–0.00006%) and controls was performed. Results: Out of the 34 subjects with contact allergy to eugenol, 21 (61.8%) showed a positive patch test before ROAT was performed, the lowest positive concentration was 0.031%. The ROAT was positive in 19 (55.9%) of the 34 subjects, the time until a positive reaction occurred was negatively associated with the concentration of the ROAT solution, as well as with the allergic reactivity of the subjects as defined by patch testing. In the patch test after ROAT, 20 of the 34 test subjects (58.8%) showed a positive reaction. In 13 (38.2%) of the 34 test subjects, the patch test result was not reproduceable, still 4 (31.0%) of these 13 subjects developed a positive ROAT. Conclusion: Eugenol can provoke a positive patch test reaction in a very low dose; besides, this hypersensitivity may persist even if a former positive patch test is not reproduceable.
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| 60. |
- Offermanns, Vincent, et al.
(författare)
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Effect of strontium surface-functionalized implants on early and late osseointegration: A histological, spectrometric and tomographic evaluation
- 2018
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Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 69, s. 385-394
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Tidskriftsartikel (refereegranskat)abstract
- Energy efficient sensing is one of the main objectives in the design of networked embedded monitoring systems. However, existing approaches such as duty cycling and ambient energy harvesting face challenges in railway bridge health monitoring applications due to the unpredictability of train passages and insufficient ambient energy around bridges. This paper presents ECOVIBE (Eco-friendly Vibration), an on-demand sensing system that automatically turns on itself when a train passes on the bridge and adaptively powers itself off after finishing all tasks. After that, it goes into an inactive state with near-zero power dissipation. ECOVIBE achieves these by: Firstly, a novel, fully passive event detection circuit to continuously detect passing trains without consuming any energy. Secondly, combining train-induced vibration energy harvesting with a transistor-based load switch, a tiny amount of energy is sufficient to keep ECOVIBE active for a long time. Thirdly, a passive adaptive off control circuit is introduced to quickly switch off ECOVIBE. Also this circuit does not consume any energy during inactivity periods. We present the prototype implementation of the proposed system using commercially available components and evaluate its performance in real-world scenarios. Our results show that ECOVIBE is effective in railway bridge health monitoring applications.
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