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Sökning: WFRF:(Andrén O.)

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41.
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42.
  • Obrochta, S. P., et al. (författare)
  • The undatables : Quantifying uncertainty in a highly expanded Late Glacial-Holocene sediment sequence recovered from the deepest Baltic Sea basin—IODP Site M0063
  • 2017
  • Ingår i: Geochemistry Geophysics Geosystems. - : American Geophysical Union (AGU). - 1525-2027. ; 18:3, s. 858-871
  • Tidskriftsartikel (refereegranskat)abstract
    • Laminated, organic-rich silts and clays with high dissolved gas content characterize sediments at IODP Site M0063 in the Landsort Deep, which at 459 m is the deepest basin in the Baltic Sea. Cores recovered from Hole M0063A experienced significant expansion as gas was released during the recovery process, resulting in high sediment loss. Therefore, during operations at subsequent holes, penetration was reduced to 2 m per 3.3 m core, permitting expansion into 1.3 m of initially empty liner. Fully filled liners were recovered from Holes B through E, indicating that the length of recovered intervals exceeded the penetrated distance by a factor of >1.5. A typical down-core logarithmic trend in gamma density profiles, with anomalously low-density values within the upper ∼1 m of each core, suggests that expansion primarily occurred in this upper interval. Thus, we suggest that a simple linear correction is inappropriate. This interpretation is supported by anisotropy of magnetic susceptibility data that indicate vertical stretching in the upper ∼1.5 m of expanded cores. Based on the mean gamma density profiles of cores from Holes M0063C and D, we obtain an expansion function that is used to adjust the depth of each core to conform to its known penetration. The variance in these profiles allows for quantification of uncertainty in the adjusted depth scale. Using a number of bulk 14C dates, we explore how the presence of multiple carbon source pathways leads to poorly constrained radiocarbon reservoir age variability that significantly affects age and sedimentation rate calculations.
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43.
  • Penney, K. L., et al. (författare)
  • mRNA expression signature of Gleason grade predicts lethal prostate cancer
  • 2011
  • Ingår i: Journal of Clinical Oncology. - : American Society of Clinical Oncology. - 0732-183X .- 1527-7755. ; 29:17, s. 2391-2396
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis.PATIENTS AND METHODS: Using the complementary DNA-mediated annealing, selection, extension, and ligation assay, we measured the mRNA expression of 6,100 genes in prostate tumor tissue in the Swedish Watchful Waiting cohort (n = 358) and Physicians' Health Study (PHS; n = 109). We developed an mRNA signature of Gleason grade comparing individuals with Gleason ≤ 6 to those with Gleason ≥ 8 tumors and applied the model among patients with Gleason 7 to discriminate lethal cases.RESULTS: We built a 157-gene signature using the Swedish data that predicted Gleason with low misclassification (area under the curve [AUC] = 0.91); when this signature was tested in the PHS, the discriminatory ability remained high (AUC = 0.94). In men with Gleason 7 tumors, who were excluded from the model building, the signature significantly improved the prediction of lethal disease beyond knowing whether the Gleason score was 4 + 3 or 3 + 4 (P = .006).CONCLUSION: Our expression signature and the genes identified may improve our understanding of the de-differentiation process of prostate tumors. Additionally, the signature may have clinical applications among men with Gleason 7, by further estimating their risk of lethal prostate cancer and thereby guiding therapy decisions to improve outcomes and reduce overtreatment.
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48.
  • Robertsson, A M, et al. (författare)
  • Pleistocene stratigraphy in the Dellen region, central Sweden
  • 1997
  • Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 26, s. 237-260
  • Tidskriftsartikel (refereegranskat)abstract
    • The Pleistocene stratigraphy in the Dellen region, central Sweden was studied using field observations made during mapping of Quaternary deposits and fabric analyses in excavated sections. The lithostratigraphy was also studied by seismic refraction measurements, analyses of grain-size distribution and organic carbon content. Biostratigraphical methods applied were pollen and diatom analyses. A general outline of the Pleistocene stratigraphy in the area is presented. Three different till beds are identified, the lowermost suggested to have been deposited during the Saalian glaciation and the other two during the Weichselian glaciation. According to the interpretation of the stratigraphy, it is questioned whether the first Weichselian ice sheer did in fact reach the Dellen area. A clayey sediment sequence at Norra Sannas accumulated during an interglacial, probably the Eemian. Most of the interglacial vegetation succession is reflected in the identified pollen flora. An initial phase with a light-demanding forest of Betula and Pinus was followed by immigration of Alnus, Picea and scattered occurrences of Corylus. A freshwater diatom flora was identified dominated by plankton taxa, e.g. Aulacoseira italica, A. distans and Cyclotella spp. In the lower part of the sequence a brackish-marine flora was registered, representing accumulation in a bay of the Eemian Sea. Fine-grained sediments at the Sundson and Vastansjo sites are interpreted as rebedded Eemiar. sediments according to the pollen flora. An (Early Weichselian) interstadial age is suggested ibr sediments found at Bjuraker. Dating by the C-14- and OSL methods was carried out on the interglacial and interstadial sediments, respectively. The ages range from approximately 19 000 to 92 000 BP. Correlation of interglacial vegetation history with central Finland and other areas is discussed.
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50.
  • Sadr-Azodi, O., et al. (författare)
  • Abdominal and Total Adiposity and The Risk of Acute Pancreatitis : A Population-Based Prospective Cohort Study
  • 2013
  • Ingår i: American Journal of Gastroenterology. - : NATURE PUBLISHING GROUP. - 0002-9270 .- 1572-0241. ; 108:1, s. 133-139
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Previous research has indicated that obesity may be linked to the severity of acute pancreatitis. However, the association between abdominal and total adiposity as risk factors in the development of acute pancreatitis in a general population has not been studied. METHODS: A follow-up study was conducted, using the Swedish Mammography Cohort and the Cohort of Swedish Men, to examine the association between waist circumference and body mass index (BMI) and the risk of first-time acute pancreatitis. Severe acute pancreatitis was defined as hospital stay of >14 days, in-hospital death, or mortality within 30 days of discharge. Cox proportional hazards models were used to estimate rate ratios (RRs) with 95% confidence intervals (CIs), adjusted for confounders. RESULTS: In total, 68,158 individuals, aged 46-84 years, were studied for a median of 12 years. During this time, 424 persons developed first-time acute pancreatitis. The risk of acute pancreatitis among those with a waist circumference of >105 cm was twofold increased (RR = 2.37; 95 % CI: 1.50-3.74) compared with individuals with a waist circumference of 75.1-85.0 cm, when adjusted for confounders. This association was seen in patients with non-gallstone-related and gallstone-related acute pancreatitis. The results remained unchanged when stratifying the analyses with regards to sex or the severity of acute pancreatitis. There was no association between BMI and the risk of acute pancreatitis. CONCLUSIONS: Abdominal adiposity, but not total adiposity, is an independent risk factor for the development of acute pancreatitis. Am J Gastroenterol 2013; 108:133-139; doi:10.1038/ajg.2012.381; published online 13 November 2012
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