| 41. |
- Wilking, N., et al.
(författare)
-
Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
- 2007
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
|
|
| 42. |
- Witzgall, P., et al.
(författare)
-
Potential of a blend of E8,E10-120H and E8,E10-12Ac for mating disruption of codling moth, Cydia pomonella L (Lep, Tortricidae)
- 1996
-
Ingår i: Journal of applied entomology. - : John Wiley & Sons. - 0931-2048 .- 1439-0418. ; 120:1-5, s. 611-614
-
Tidskriftsartikel (refereegranskat)abstract
- Dispensers of E8,E10-12OH (codlemone), E8,E10-12Ac (codlemone acetate), or both dispenser types were placed on the corners of 100 m(2) and 300 m(2) plots within apple orchards. Communication disruption of male codling moths, Cydia pomonella, was monitored with pheromone traps in the centres of these plots. In the 300 m(2) plots, trap catch was reduced only by codlemone. In the 100 m(2) plots, trap catch was reduced in all three treatments, fewest males were caught in plots treated with both codlemone and codlemone acetate. Males were attracted to codlemone dispensers, they were also flying actively around the tree crowns, well above the dispensers. This behaviour was not observed in treatments with codlemone acetate, where male orientation flights were directed only towards the trap in the plot centre. The antagonistic effect of each of the four geometric isomers of codlemone acetate was shown by another trap test. Addition of 20% E,E-; E,Z-; Z,E- or Z8,Z10-12Ac decreased male attraction to traps baited with E8, E10-12OH.
|
|
| 43. |
- Wormser, David, et al.
(författare)
-
Adult height and the risk of cause-specific death and vascular morbidity in 1 million people : individual participant meta-analysis
- 2012
-
Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 41:5, s. 1419-1433
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.MethodsWe calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.ResultsFor people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.ConclusionAdult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.
|
|
| 44. |
- Yadav, R. B., et al.
(författare)
-
Identification of triaxial strongly deformed bands in Hf-168
- 2008
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 78:4
-
Tidskriftsartikel (refereegranskat)abstract
- Possible decay pathways associated with three candidates for triaxial strongly deformed (TSD) bands in Hf-168 have been investigated. The spin and excitation energy of the strongest band, TSD1, were determined approximately based on gamma-ray coincidence relationships. Discrete links were established for the second band. The overall agreement between the observed properties of the bands and cranking calculations using the ULTIMATE CRANKER code provides strong support for an interpretation where band TSD1 is associated with a TSD minimum, (epsilon(2),gamma)similar to(0.43,20(degrees)), involving the pi(i(13/2))(2) and the nu(j(15/2)) high-j orbitals. This constitutes the first identification of a TSD band in Hf isotopes, which has been long-predicted by theoretical studies. The second band is understood as being associated with a near-prolate shape and a deformation enhanced with respect to the normal deformed bands. It is proposed to be built on the pi(i(13/2)h(9/2))circle times nu(i(13/2))(2) configuration.
|
|
| 45. |
- Al-Khatib, A, et al.
(författare)
-
Transition to non-collective states at high spin in Xe-124
- 2008
-
Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 36:1, s. 21-29
-
Tidskriftsartikel (refereegranskat)abstract
- Excited states in Xe-124 were populated in the reaction Se-82(Ca-48, 6n) Xe-124 and gamma-ray coincidence relationships were measured with the Gammasphere spectrometer. Two new bands are observed and several of the previously known bands are extended in the high-as well as in the low-spin region. Two irregular high-spin structures are also added. The irregularities are a fingerprint of a transition from collective to non-collective behaviour. Configuration assignments to the new structures are proposed on the basis of systematics and by comparing experimental properties with calculations within the framework of the cranking model.
|
|
| 46. |
- Bengtsson, BE, et al.
(författare)
-
Reproductive disturbances in Baltic fish: A synopsis of the FiRe project
- 1999
-
Ingår i: AMBIO. - : ROYAL SWEDISH ACAD SCIENCES. - 0044-7447. ; 28:1, s. 2-8
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Research within the Swedish FiRe project Reproductive Disturbances in Baltic Fish has focused mainly on the M74 syndrome, which has caused high mortality in fry of sea-run Atlantic salmon (Salmo salar) from the Baltic Sea. At the end of the 4-year project
|
|
| 47. |
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
|
|
