| 21. |
|
|
| 22. |
|
|
| 23. |
- Nyhlén, Sara, et al.
(författare)
-
Att studera lokalt beslutsfattande
- 2015
-
Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144105154 ; , s. 73-77
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 24. |
- Nyhlén, Sara, 1980-, et al.
(författare)
-
Att studera lokalt beslutsfattande
- 2022. - 2
-
Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144155937 ; , s. 87-90
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 25. |
- Nyhlén, Sara, 1980-, et al.
(författare)
-
When social inequality goes beyond the nation state : analyzing how Swedish municipalities handle vulnerable EU-migrants
- 2017
-
Konferensbidrag (refereegranskat)abstract
- Since 2012 Sweden has faced a seemingly new situation with social inequality displaying itself as an increasing amount of homeless people making a living mainly as beggars in Swedish cities and towns. With the Swedish welfare state and the far reaching local autonomy this situation with social inequality is left to each municipality to decide upon how to handle. The situation is growing in complexity since the majority of the people in the precarious situation are so called “EU-migrants” which means that they are people traveling within EU seeking a better life trying to avoid poverty, unemployment and many times harassments and racism. In this study we have analyzed how it comes that this situation is handled differently by local authorities. Applying a most similar system design we look at how 7 municipalities within a region in the northern parts of Sweden handle the situation with social vulnerability. Given that the municipalities have the same political majority, are located in the same region and are ruled by the same national policies, we pose the question why is the outcome so different? The study shows how the local public officials and politicians are negotiating rights, citizenship and needs and how boundaries are drawn within the welfare state.
|
|
| 26. |
- Olausson, Pär M., et al.
(författare)
-
Lokalt beslutsfattande - en introduktion
- 2015
-
Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144105154 ; , s. 11-20
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 27. |
- Olausson, Pär M., Docent, 1968-, et al.
(författare)
-
Lokalt beslutsfattande - en introduktion
- 2022. - 2
-
Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144155937 ; , s. 13-24
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 28. |
- Olofsdotter, Gunilla, 1957-, et al.
(författare)
-
Study protocol: Local labour market programs–institutional structures, organizational forms and lived experiences
- 2024
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 19:1
-
Tidskriftsartikel (refereegranskat)abstract
- In this programme, we map and examine local labour market programmes (LLMPs) at the municipal level in Sweden. This includes their institutional structure and organisation, as well as the experiences of participants in the programmes, using a longitudinal approach with the aim to improve LLMPs. The long-term goal is to increasing the inclusion of LLMP participants in working life. To answer the programme’s questions, data will be collected and analysed within the four work packages. In each work package, a mixed-method approach is applied with a combination of quantitative and qualitative methods. The programme is informed by three overarching general theoretical approached, tying together institutional ethnography, intersectional studies of structural inequalities on different levels, and the role of emotions in everyday work. At the organisational level (WP 1), we will investigate the circumstances under which LLMPs are performed and negotiated by those involved. Here, the internal organisation, activities and methods are the focus. This approach will result in knowledge about the characteristics of these organisations and the factors promoting the inclusion of underrepresented groups in working life. By examining the activities in LLMPs (WP 2), we will be able to determine how their institutional structure differs between regions in Sweden, how the different municipalities work with labour market policy, how they translate national policy into the local context, how they organise their work and which initiatives they choose to adopt. By examining the individual experiences of those who are directly affected by such incentives (WP 3), knowledge and understanding will be obtained of the connections between experiences and labour market policies. This will give important insights into the functioning of local programmes and of the opportunities to create entry into the labour market. Furthermore, in WP4 we will develop and test an effect evaluation of work methods used in LLMPs and their effect on clients’ progress over time.
|
|
| 29. |
- Rahmanto, Aldwin Suryo, et al.
(författare)
-
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
- 2016
-
Ingår i: EMBO Journal. - : EMBO. - 0261-4189 .- 1460-2075. ; 35:20, s. 2192-2212
-
Tidskriftsartikel (refereegranskat)abstract
- SOX9 is a master transcription factor that regulates development and stem cell programs. However, its potential oncogenic activity and regulatory mechanisms that control SOX9 protein stability are poorly understood. Here, we show that SOX9 is a substrate of FBW7, a tumor suppressor, and a SCF (SKP1/CUL1/F-box)-type ubiquitin ligase. FBW7 recognizes a conserved degron surrounding threonine 236 (T236) in SOX9 that is phosphorylated by GSK3 kinase and consequently degraded by SCFFBW7 alpha. Failure to degrade SOX9 promotes migration, metastasis, and treatment resistance in medulloblastoma, one of the most common childhood brain tumors. FBW7 is either mutated or downregulated in medulloblastoma, and in cases where FBW7 mRNA levels are low, SOX9 protein is significantly elevated and this phenotype is associated with metastasis at diagnosis and poor patient outcome. Transcriptional profiling of medulloblastoma cells expressing a degradation-resistant SOX9 mutant reveals activation of pro-metastatic genes and genes linked to cisplatin resistance. Finally, we show that pharmacological inhibition of PI3K/AKT/mTOR pathway activity destabilizes SOX9 in a GSK3/FBW7-dependent manner, rendering medulloblastoma cells sensitive to cytostatic treatment.
|
|
| 30. |
- Roy, Ananya, et al.
(författare)
-
Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation
- 2014
-
Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 289:1, s. 237-250
-
Tidskriftsartikel (refereegranskat)abstract
- During infection and tissue damage, virulence factors and alarmins are pro-inflammatory and induce activation of various immune cells including macrophages and mast cells (MCs). Activated MCs instantly release preformed inflammatory mediators, including several proteases. The chymase mouse mast cell protease (MCPT)-4 is thought to be pro-inflammatory, whereas human chymase also degrades pro-inflammatory cytokines, suggesting that chymase instead limits inflammation. Here we explored the contribution of MCPT4 and human chymase to the control of danger-induced inflammation. We found that protein extracts from wild type (WT), carboxypeptidase A3-, and MCPT6-deficient mice and MCs and recombinant human chymase efficiently degrade the Trichinella spiralis virulence factor heat shock protein 70 (Hsp70) as well as endogenous Hsp70. MC-(W-sash)-, serglycin-, NDST2-, and MCPT4-deficient extracts lacked this capacity, indicating that chymase is responsible for the degradation. Chymase, but not MC tryptase, also degraded other alarmins, i.e. biglycan, HMGB1, and IL-33, a degradation that was efficiently blocked by the chymase inhibitor chymostatin. IL-7, IL-22, GM-CSF, and CCL2 were resistant to chymase degradation. MCPT4-deficient conditions ex vivo and in vivo showed no reduction in added Hsp70 and only minor reduction of IL-33. Peritoneal challenge with Hsp70 resulted in increased neutrophil recruitment and TNF- levels in the MCPT4-deficient mice, whereas IL-6 and CCL2 levels were similar to the levels found in WT mice. The rapid and MC chymase-specific degradation of virulence factors and alarmins may depend on the presence of accessible extended recognition cleavage sites in target substrates and suggests a protective and regulatory role of MC chymase during danger-induced inflammation.
|
|
