↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Bonanni B) "

Sökning: WFRF:(Bonanni B)

Resultat 21-30 av 108

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
21.	Mavaddat, N, et al. (författare) Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes 2019 Ingår i: American journal of human genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 104:1, s. 21-34 Tidskriftsartikel (refereegranskat)
22.	Maxwell, Christopher A., et al. (författare) Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer 2011 Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885 .- 1544-9173. ; 9:11 Tidskriftsartikel (refereegranskat)abstract Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.
23.	Michailidou, K, et al. (författare) Association analysis identifies 65 new breast cancer risk loci 2017 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 551:7678, s. 92- Tidskriftsartikel (refereegranskat)
24.	Rebbeck, TR, et al. (författare) Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations 2018 Ingår i: Human mutation. - : Hindawi Limited. - 1098-1004 .- 1059-7794. ; 39:5, s. 593-620 Tidskriftsartikel (refereegranskat)
25.	Rebbeck, Timothy R, et al. (författare) Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. 2015 Ingår i: JAMA: The Journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:13, s. 1347-1361 Tidskriftsartikel (refereegranskat)abstract Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.
26.	Coignard, J, et al. (författare) A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers 2021 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 1078- Tidskriftsartikel (refereegranskat)abstract Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
27.	Coignard, J, et al. (författare) Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers 2021 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 2986- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4
28.	Escala-Garcia, M, et al. (författare) Genome-wide association study of germline variants and breast cancer-specific mortality 2019 Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 120:6, s. 647-657 Tidskriftsartikel (refereegranskat)
29.	Jakubowska, A, et al. (författare) Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study 2012 Ingår i: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 106:12, s. 2016-2024 Tidskriftsartikel (refereegranskat)
30.	Kuchenbaecker, KB, et al. (författare) Identification of six new susceptibility loci for invasive epithelial ovarian cancer 2015 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:2, s. 164-171 Tidskriftsartikel (refereegranskat)

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 21-30 av 108

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (106); konferensbidrag (2)

Typ av innehåll: refereegranskat (105); övrigt vetenskapligt/konstnärligt (3)

Författare/redaktör: Bonanni, B. (69); Hamann, U (56); Nevanlinna, H (56); Benitez, J. (55); Peterlongo, P (55); Andrulis, IL (55); visa fler...; Radice, P (54); Chenevix-Trench, G (54); Easton, DF (54); Jakubowska, A (51); Couch, FJ (49); Lubinski, J (47); Devilee, P (46); Southey, MC (45); Glendon, G (45); Fasching, PA (45); Hopper, JL (44); Schmutzler, RK (44); Dennis, J (42); Schmidt, MK (42); Chang-Claude, J (42); Lindblom, A (41); Milne, RL (41); Simard, J (41); Pharoah, PDP (41); Dunning, AM (40); Evans, DG (40); Czene, K (39); Giles, GG (39); Mannermaa, A (39); Meindl, A (39); Bolla, MK (38); Manoukian, S (38); Garcia-Closas, M (38); Aittomaki, K (38); Dork, T (38); Hall, P (37); Beckmann, MW (37); Bojesen, SE (37); Lambrechts, D (37); Engel, C. (37); Anton-Culver, H (36); Margolin, S (36); Hooning, MJ (36); Burwinkel, B (35); Flyger, H (35); Mulligan, AM (35); Wang, Q. (34); Haiman, CA (34); Neuhausen, SL (34); visa färre...

Lärosäte: Karolinska Institutet (97); Lunds universitet (45); Uppsala universitet (31); Linköpings universitet (8); Göteborgs universitet (6); Umeå universitet (6); visa fler...; Kungliga Tekniska Högskolan (4); Chalmers tekniska högskola (2); Linnéuniversitetet (2); Örebro universitet (1); Jönköping University (1); visa färre...

Språk: Engelska (108)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (52); Naturvetenskap (9); Teknik (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy