| 21. |
- Ljungman, P., et al.
(författare)
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Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy
- 2012
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 1476-5365 .- 0268-3369. ; 47:9, s. 1217-1221
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Tidskriftsartikel (refereegranskat)abstract
- This prospective study was initiated in 1993 with the aim to study late effects and responses to antiviral therapy in a cohort of hepatitis C virus (HCV)-infected patients. A total of 195 patients were included from 12 centers. In all, 134 patients had undergone allogeneic and 61 autologous hematopoietic SCT (HSCT). The median follow-up from HSCT is currently 16.8 years and the maximum 27.2 years. Overall 33 of 195 patients have died of which 6 died from liver complications. The survival probability was 81.6% and the cumulative incidence for death in liver complications was 6.1% at 20 years after HSCT. The cumulative incidence of severe liver complications (death from liver failure, cirrhosis and liver transplantation) was 11.7% at 20 years after HSCT. In all, 85 patients have been treated with IFN; 42 in combination with ribavirin. The sustained response rate was 40%. The rates of severe side effects were comparable to other patient populations and no patient developed significant exacerbations of GVHD. Patients receiving antiviral therapy had a trend toward a decreased risk of severe liver complications (odds ratio=0.33; P=0.058). HCV infection is associated with morbidity and mortality in long-term survivors after HSCT. Antiviral therapy can be given safely and might reduce the risk for severe complications.
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| 22. |
- Ljungman, P., et al.
(författare)
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Respiratory virus infections after stem cell transplantation : a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
- 2001
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 28:5, s. 479-484
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Tidskriftsartikel (refereegranskat)abstract
- Community-acquired respiratory virus infections are a cause of mortality after stem cell transplantation (SCT). A prospective study was performed at 37 centers to determine their frequency and importance. Additional cases were also collected to allow the analysis of risk factors for severe infection. Forty episodes were collected in the prospective study and 53 additional episodes through subsequent case collection. The frequency of documented respiratory virus infections was 3.5% among 819 allogeneic and 0.4% among 1154 autologous SCT patients transplanted during the study period. The frequency of lower respiratory tract infections (LRTI) was 2.1% among allogeneic and 0.2% among autologous SCT patients. The mortality within 28 days from diagnosis of a respiratory viral infection was 1.1% among allogeneic SCT while no autologous SCT patient died. The deaths of five patients (0.6%) were directly attributed to a respiratory virus infection (three RSV; two influenza A). On multivariate analysis, lymphocytopenia increased the risk for LRTI (P = 0.008). Lymphocytopenia was also a significant risk factor for LRTI in patients with RSV infections. The overall mortality in RSV infection was 30.4% and the direct RSV-associated mortality was 17.4%. For influenza A virus infection, the corresponding percentages were 23.0% and 15.3%. This prospective study supports the fact that community-acquired respiratory virus infections cause transplant-related mortality after SCT.
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| 23. |
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| 24. |
- Wirström, Eva, 1977, et al.
(författare)
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Effect of the 3D distribution on water observations made with the SWI: I. Ganymede
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 637
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Tidskriftsartikel (refereegranskat)abstract
- Context. Characterising and understanding the atmospheres of Jovian icy moons is one of the key exploration goals of the Submillimetre Wave Instrument (SWI), which is to be flown on ESA's Jupiter Icy Moons Explorer (JUICE) mission. Aims. The aim of this paper is to investigate how and under which conditions a 3D asymmetric distribution of the atmosphere may affect the SWI observations. In this work we target the role of phase angle for both nadir and limb geometries for unresolved and partially resolved disc observations from large distances.Methods. We adapted the LIME software package, a 3D non-local thermodynamical equilibrium radiative transfer model, to evaluate ortho-H2O populations and synthesise the simulated SWI beam spectra for different study cases of Ganymede's atmosphere. The temperature and density vertical distributions were adopted from a previous work. The study cases presented here were selected according to the distance and operational scenarios of moon monitoring anticipated for SWI during the Jupiter phase of the JUICE mission. Results. We demonstrate that nadir and limb observations at different phase angles will modify the line amplitude and width. Unresolved observations where both absorption against surface continuum and limb emission contributes within the beam will lead to characteristic line wing emission, which may also appear in pure nadir geometry for specific phase angles. We also find that for Ganymede, the 3D non-local thermodynamical equilibrium populations are more highly excited in the upper atmosphere near the sub-solar region than they are in 1D spherically symmetric models. Finally, the 3D radiative transfer is better suited to properly simulate spectral lines for cases where density or population gradients exist along the line of sight.
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