| 11. |
- Carlberg, Patrick, et al.
(författare)
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Nanoimprint - a tool for realizing nano-bio research
- 2004
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Ingår i: 2004 4th IEEE Conference on Nanotechnology. - 0780385365 ; , s. 199-200
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Konferensbidrag (refereegranskat)abstract
- In this paper, we present a status report on how implementation of nanoimprint lithography has advanced our research. Contact guidance nerve growth experiments have so far primarily been done on micrometer-structured surfaces. We have made a stamp with 17 areas of different, submicron, line width and spacing covering a total 2.6 mm
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| 12. |
- Goncalves, Dulce, 1968-, et al.
(författare)
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Cultural aspects of organizational agility affecting digital innovation
- 2020
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Ingår i: Journal of Entrepreneurship, Management, and Innovation. - Nowy Targ : Fundacja Cognitione. - 2299-7075 .- 2299-7326. ; 16:4, s. 13-46
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study is to understand how the cultural aspects of organizational agility affect digital innovation capability. In the context of increasing demand for fast-paced digital innovation, organizational agility becomes strategically crucial for large incumbent companies to increase their competitiveness. The literature on organizational agility shows that incumbents, with their vast access to resources, still can have limited ability to innovate and respond to change. This is in sharp contrast to startups, who sometimes are impressively innovative despite their very limited resources. Sometimes the incumbents are even outcompeted and disrupted by startups because of their ability to embrace change, and rapidly seize new business opportunities. However, we know little about why some incumbents are not able to use their resources efficiently for digital innovation and why some smaller startups can transcend these resource limitations. In this context, we find that cultural aspects are especially crucial as enablers for organizational agility in digital innovation. We designed a comparative study to investigate the differences in the influence of culture on organizational agility; and how it hinders or enables digital innovation, at both incumbent firms and startups in the automotive industry. We applied a qualitative research approach and selected semi-structured interviews as our main research method. The Competing Values Framework was used as a tool to categorize different cultures that affect organizational agility, but also to identify how and when tensions between values supported or hampered the organizations’ ability to innovate. Our findings show that, while a blend of Hierarchy and Market cultures inhibited the innovation capability, Clan and Adhocracy cultures promoted innovation. In our sample, the incumbents predominantly adhered to the first two cultures, while the startups typically belonged to the second group. The most successful startups were even able to create a combination of Clan and Adhocracy cultures — a concept we here term ‘Agile culture.’ This culture allowed them to reach a beneficial state of digital innovation growth. When it comes to the implications for research and practice, we found the need to analyze the role of culture for organizational agility; and how to utilize culture as an asset to enable digital innovation growth. One contribution is the identification of ‘Agile culture’ that is an amalgamation of Clan and Adhocracy culture. The value agile culture creates when applied, enables organizational agility, which can enhance digital innovation capability.
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| 13. |
- Gonçalves, Dulce, 1968-, et al.
(författare)
-
How co-creation supports digital innovation in automotive startups
- 2021
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Ingår i: ECIS 2021. - Illinois : Association for Information Systems. - 9781733632560
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Konferensbidrag (refereegranskat)abstract
- Co-creation is an essential aspect of organizational agility enabling organizations to gain digital in- novation capabilities, such as support in developing critical peripheral services or attracting talents and investors. Co-creation is especially essential for startups because of their limited resources. It fosters organizations to learn and innovate across company boundaries to remain competitive. Little is known about how startups apply co-creation to support their digital innovation initiatives. This paper presents a qualitative study of eight automotive startups, based on 22 semi-structured interviews. We applied the prediction and control framework as an analytic lens and identified three key advantages of co-creation. Embracing co-creation in ecosystems increases startups' resource capacity and speed for digital innovation. We concluded that automotive startups that apply visionary and transformative logic were found to have a better ability to lead digital innovation in a controlled way and attract wanted talents and actors.
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| 14. |
- Gonçalves, Dulce, 1968-, et al.
(författare)
-
How Digital Tools Align with Organizational Agility and Strengthen Digital Innovation in Automotive Startups
- 2022
-
Konferensbidrag (refereegranskat)abstract
- Digital tools can be an enabler for automotive startups to strengthen their digital innovation capability. Still, few empirical studies describe how automotive startups apply digital tools to do this. Digital innovation capability is essential for survival in a volatile global digital marketplace. Therefore, we conducted a qualitative study based on 23 interviews with nine global automotive startups to understand how they apply digital tools to strengthen their digital innovation. The results showed that automotive startups use cloud services almost exclusively for their business. We conclude that startups choose to use digital tools as SaaS to strengthen their organizational agility and digital innovation initiatives. It harmonizes with their agile culture, effectively enabling innovation collaborations between employees internally and with external actors enabling rapidness to market. SaaS providers' startup programs enabled startups to remain focused on their innovation initiatives and not worry about scalability since the solutions scaled from the start. © 2021 Elsevier B.V. All rights reserved.
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| 15. |
- Goncalves, Dulce, 1968-, et al.
(författare)
-
The Influence of Cultural Values on Organizational Agility
- 2019
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Ingår i: AMCIS 2019 Proceedings. - : Association for Information Systems. - 9780996683180 ; , s. 1-10
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Konferensbidrag (refereegranskat)abstract
- Organizational agility, a firm’s ability to manage dynamic change, has become strategically important for companies in their innovation work. In this context cultural aspects are especially important, as they can both support and hamper organizational agility. Differences can generate innovation ability but they can also create conflicts between competing value systems, thus reducing the firm’s ability to develop organizational agility to support innovation processes. We conducted a comparative study in incumbent firms and startups in the automotive industry to identify the influence of entrepreneurial cultural values on organizational agility. The Competing Values Framework was applied to identify the relationship between cultural values and organizational agility. The result shows that cultural differences affect the companies ability to develop organizational agility for innovation work. In particular incumbents struggled to enable a change towards organizational agility. We found that startups integrated Clan and Adhocracy into an agile culture, which enabled continuous innovation growth.
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| 16. |
- Haghighi, Mona, et al.
(författare)
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A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
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| 17. |
- Ling, TGI, et al.
(författare)
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Fa-brication and characterization of a molecular adhesive layer for micro- and nanofabricated electrochemical electrodes
- 2003
-
Ingår i: Microelectronic Engineering. - 1873-5568. ; 67-8, s. 887-892
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Tidskriftsartikel (refereegranskat)abstract
- In the microelectronics industry, gold electrodes on silicon dioxide are produced using an adhesive layer of chromium or titanium. This method is applicable whenever a dry environment is present. However, when such an electrode is exposed to an electrolyte a galvanic cell is formed and the less noble metal will dissolve and eventually destroy the electrode. We describe here how a monolayer of mercaptopropyl-trimethoxysilane (MPTS) can be used as an adhesive. The layer can be structured lithographically making gold electrodes in the micro- and nano-range applicable for use in electrochemistry. The properties of the MPTS layer were investigated with photoelectron microscopy, atomic force microscopy and the electrochemical performance of the gold electrodes was determined by cyclic voltammetry. (C) 2003 Elsevier Science B.V. All rights reserved.
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| 18. |
- Mansson, A, et al.
(författare)
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Actin-based molecular motors for cargo transportation in nanotechnology - Potentials and challenges
- 2005
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Ingår i: IEEE Transactions on Advanced Packaging. - 1521-3323. ; 28:4, s. 547-555
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Tidskriftsartikel (refereegranskat)abstract
- Here, we review the use of actin-based motors, (myosins; e.g., the molecular motor of muscle) in. nanotechnology. The review starts from the viewpoints of the molecular motors as being important devices responsible of cargo transportation in the cell and end in discussions about their employment in nanotechnological applications. First, we describe basic biophysics of the myosin motors with focus on their involvement in cargo transportation in the living cell, leading us over into a discussion about in vitro motility assays. These are biological test systems where the myosin-induced translocation of actin filaments is studied on an artificial surface outside the cell. Then follows a review about modified motility assays for production of ordered motion. Here, we discuss ours and others' work with regards to making micro- and nanostructured surfaces and channels where the position and direction of movement produced by molecular motors is controlled. In this section, we consider the role of the channel size in promoting unidirectional myosin-induced motion of actin filaments. Furthermore, we consider the usefulness of surface modifications, e.g., various silanization procedures in order to promote and hinder molecular motility, respectively. Particularly, we describe our latest test system being both morphologically and chemically nanostructured giving us unsurpassed possibilities to perform functional studies as well as extremely good spatio-temporal control. Then follows a section about nanotechnological cargo transportation systems based on the actomyosin motor system. For instance, we present results of attaching fluorescent quantum dots as cargoes to the actin filaments. In this section, we also discuss the possibilities of having cargo attachment and detachment being performed on demand. Finally, we consider the usefulness of molecular motors for lab-on-a-chip applications and the requirements for incorporating these motors in commercially viable devices. In this context, the significant potential of the actomyosin motor system to overcome traditional limitations of micro- and nanofluidics is stressed.
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| 19. |
- Mansson, A, et al.
(författare)
-
In vitro sliding of actin filaments labelled with single quantum dots
- 2004
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 314:2, s. 529-534
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Tidskriftsartikel (refereegranskat)abstract
- We recently refined the in vitro motility assay for studies of actomyosin function to achieve rectified myosin induced sliding of actin filaments. This paves the way, both for detailed functional studies of actomyosin and for nanotechnological applications. In the latter applications it would be desirable to use actin filaments for transportation of cargoes (e.g., enzymes) between different predetermined locations on a chip. We here describe how single quantum dot labelling of isolated actin filaments simultaneously provides handles for cargo attachment and bright and photostable fluorescence labels facilitating cargo detection and filament tracking. Labelling was achieved with preserved actomyosin function using streptavidin-coated CdSe quantum dots (Qdots). These nanocrystals have several unique physical properties and the present work describes their first use for functional studies of isolated proteins outside the cell. The results, in addition to the nanotechnology developments, open for new types of in vitro assays of isolated biomolecules. (C) 2003 Elsevier Inc. All rights reserved.
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| 20. |
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