| 11. |
- Deshmukh, K. P., et al.
(författare)
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Cleaning of simple cohesive soil layers in a radial flow cell
- 2022
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Ingår i: Food and Bioproducts Processing. - : Elsevier BV. - 0960-3085. ; 136, s. 84-96
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Tidskriftsartikel (refereegranskat)abstract
- A radial flow cell (RFC, inlet tube radius 0.95 mm and gaps of 1–4.2 mm) was used to investigate the removal of two thin (80–230 µm thick) model soil layers from glass and 304 stainless steel substrates by the flow of water at 20 °C. Under the flow conditions employed (Reynolds numbers 200–1400), inertial effects give rise to recirculation zones and regions of high shear stress on the bottom, soiled plate. The soils were dried layers of (i) instant coffee and (ii) a domestic abrasive cleaning suspension comprising fine particulates in a soluble matrix. Cleaning data exhibited a constant local erosion rate which varied strongly with radial position. For both soils, cleaning involved the growth of a circular cleaned region and redeposition of particulate matter in a ring at locations close to the foot of the secondary recirculation zone predicted by 2D axisymmetric CFD simulations. Removal beyond this location was observed with the coffee layers, indicating that cleaning for this soil was controlled primarily by simple diffusion mechanisms. The effect of channel aspect ratio and flow rate on the location of recirculation zones and shear stress distributions was investigated. The local cleaning rate in these steady flows was not linked simply to local wall shear stress.
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| 12. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 13. |
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| 14. |
- Morris, A, et al.
(författare)
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The Development of a Multidisciplinary System to Understand Causal Factors in Road Crashes
- 2006
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Ingår i: 42nd Annual Human Factors and Ergonomics Society of Australia Conference 2006, HFESA 2006. - 9781622769599 ; , s. 31-38
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The persistent lack of crash causation data to help inform and monitor road and vehicle safety policy is a major obstacle. Data are needed to assess the performance of road and vehicle safety stakeholders and is needed to support the development of further actions. A recent analysis conducted by the European Transport Safety Council identified that there was no single system in place that could meet all of the needs and that there were major gaps including in-depth crash causation information. This paper describes the process of developing a data collection and analysis system designed to fill these gaps. A project team with members from 7 countries was set up to devise appropriate variable lists to collect crash causation information under the following topic levels: accident, road environment, vehicle, and road user, using two quite different sets of resources: retrospective detailed police reports (n=1300) and prospective, independent, on-scene accident research investigations (n=1000). Data categorisation and human factors analysis methods based on Cognitive Reliability and Error Analysis Method (Hollnagel, 1998) were developed to enable the causal factors to be recorded, linked and understood. A harmonised, prospective "on-scene" method for recording the root causes and critical events of road crashes was developed. Where appropriate, this includes interviewing road users in collaboration with more routine accident investigation techniques. The typical level of detail recorded is a minimum of 150 variables for each accident. The project will enable multidisciplinary information on the circumstances of crashes to be interpreted to provide information on the causal factors. This has major applications in the areas of active safety systems, infrastructure and road safety, as well as for tailoring behavioural interventions. There is no direct model available internationally that uses such a systems based approach.
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| 15. |
- Ozsahin, Hulya, et al.
(författare)
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Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation.
- 2008
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 111:1, s. 439-45
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Tidskriftsartikel (refereegranskat)abstract
- Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS patients who received transplants between 1979 and 2001 who survived at least 2 years following hematopoietic stem-cell transplantation (HSCT). Events included chronic graft-versus-host disease (cGVHD), autoimmunity, infections, and sequelae of before or after HSCT complications. Three patients (3%) died 2.1 to 21 years following HSCT. Overall 7-year event-free survival rate was 75%. It was lower in recipients of mismatched related donors, also in relation with an older age at HSCT and disease severity. The most striking finding was the observation of cGVHD-independent autoimmunity in 20% of patients strongly associated with a mixed/split chimerism status (P < .001), suggesting that residual-host lymphocytes can mediate autoimmune disease despite the coexistence of donor lymphocytes. Infectious complications (6%) related to splenectomy were also significant and may warrant a more restrictive approach to performing splenectomy in WAS patients. Overall, this study provides the basis for a prospective, standardized, and more in-depth detailed analysis of chimerism and events in long-term follow-up of WAS patients who receive transplants to design better-adapted therapeutic strategies.
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| 16. |
- Syres, K. L., et al.
(författare)
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Pyrocatechol as a surface capping molecule on raffle TiO2 (110)
- 2012
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Ingår i: Surface Science. - : Elsevier BV. - 0039-6028. ; 606:3-4, s. 273-277
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Tidskriftsartikel (refereegranskat)abstract
- A 'cap and dip' method of adsorbing ruthenium di-2,2'-bipyridy1-4,4'-dicarboxylic acid diisocyanate (N3 dye) on a rutile TiO2 (110) surface was investigated using pyrocatechol as a capping molecule. This method involves cleaning the rutile surface in ultra-high vacuum (UHV), depositing pyrocatechol onto the surface to 'cap' the adsorption sites, removing from vacuum, 'dipping' in an N3 dye solution and returning to vacuum. Photoemission measurements following the return of the crystal to vacuum suggest that the pyrocatechol keeps the surface free from contamination on exposure to atmosphere. Photoemission spectra also indicate that the pyrocatechol capping molecules are replaced by the N3 dye in solution and that the N3 dye is adsorbed intact on the nitile TiO2 (110) surface. This technique may allow other large molecules, which are thermally unstable to evaporation in UHV, to be easily deposited onto TiO2 surfaces. (C) 2011 Elsevier B.V. All rights reserved.
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