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Sökning: WFRF:(Cavallini M)

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  • Andersson, Karin, 1972, et al. (författare)
  • Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
  • 2015
  • Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:24, s. 20043-20057
  • Tidskriftsartikel (refereegranskat)abstract
    • Follicular T helper (Tfh) cells are recognized by the expression of CXCR5 and the transcriptional regulator Bcl-6. Tfh cells control B cell maturation and antibody production, and if deregulated, may lead to autoimmunity. Here, we study the role of the proto-oncogene survivin in the formation of Tfh cells. We show that blood Tfh cells of patients with the autoimmune condition rheumatoid arthritis, have intracellular expression of survivin. Survivin was co-localized with Bcl-6 in the nuclei of CXCR5(+)CD4 lymphocytes and was immunoprecipitated with the Bcl-6 responsive element of the target genes. Inhibition of survivin in arthritic mice led to the reduction of CXCR5(+) Tfh cells and to low production of autoantibodies. Exposure to survivin activated STAT3 and induced enrichment of PD-1(+)Bcl-6(+) subset within Tfh cells. Collectively, our study demonstrates that survivin belongs to the Tfh cell phenotype and ensures their optimal function by regulating transcriptional activity of Bcl-6.
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23.
  • Bergenti, I., et al. (författare)
  • Structural and magnetic properties of thin manganite films grown on silicon substrates
  • 2005
  • Ingår i: Progress in Solid State Chemistry. - : Elsevier BV. - 0079-6786 .- 1873-1643. ; 33:2-4 SPEC. ISS., s. 293-298
  • Tidskriftsartikel (refereegranskat)abstract
    • Polycrystalline La0.7Sr0.3MnO3 manganite thin films were grown on silicon substrates covered by SiOx amorphous native oxide. Unusual splitting of the manganite layer was found: on the top of an intermediate layer characterised by lower crystalline order, a magnetic robust layer is formed. Curie temperatures of about 325 K were achieved for 70 nm thick films. A strong room temperature XMCD signal was detected indicating high spin polarisation near the surface. © 2005 Elsevier Ltd. All rights reserved.
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